Polyvinylpyrrolidone (PVP)‐Capped Pt Nanocubes with Superior Peroxidase‐Like Activity

Abstract

Peroxidase mimics composed of inorganic nanoparticles are expected to circumvent the inherent difficulties of natural peroxidases, and to provide enhanced performance in important applications such as diagnosis and imaging. Despite the reports of a variety of peroxidase mimics in the past decade, very limited progress has been made on improving their catalytic efficiency. The catalytic efficiencies of most previously reported mimics are only up to one order of magnitude higher than those of natural peroxidases. In this work, we demonstrate a highly efficient peroxidase—polyvinylpyrrolidone (PVP)‐capped Pt nanocubes of sub‐10 nm in size. These PVP‐capped Pt cubes are ≈200‐fold more active than the natural counterparts and exhibit a record‐high specific catalytic efficiency. In addition to the superior efficiency, the new mimic shows several other promising features, including excellent stabilities, well‐controlled uniformity in both size and shape, controllable sizes, and facile and scalable production.

Au3+‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O2•− and •OH Generating Nanozymes and Their Antibacterial Functions

“…Substantial recent research efforts are directed in the recent years to develop artificial nanomaterials emulating the functions of native enzyme-"nanozymes." [1][2][3][4][5][6] Inorganic metal oxides, [7][8][9][10][11][12][13][14] such as Fe 3 O 4 , V 2 O 5 , CeO 2 , MoO 3 , metal nanoparticles, such as Au, [15][16][17] Ag, [18,19] Pd, [20,21] or carbon based nanoparticles, such as carbon dots, [22] graphene quantum dots, [23] metal ionsfunctionalized nanomaterial, [22] core-shell inorganic nanomaterial composites, [24][25][26][27][28] for example, Fe 3 O 4 @C, Fe@BC, Cu@Pt, Au@CeO 2 , Au@Pt 4L , and inorganic cluster nanoparticles, such as Prussian Blue, [29,30] or hafnium metal-oxo clusters [31] demonstrated enzyme-like catalytic activities. Also, organic nanoparticles, for example, melanine, [32] polyethylenimine, [33] were NMOFs yields an unprecedented OXD-mimicking catalyst that use oxygen as oxidant.…”

Aptamer-Modified Cu2+-Functionalized C-Dots: Versatile Means to Improve Nanozyme Activities-“Aptananozymes”

“…Substantial research efforts are directed to the development of inorganic, organic, or metal–organic framework nanoparticles that mimic the functions of native enzymes, “nanozymes”. 1 Inorganic nanoparticles, such as Fe 3 O 4 , 2 V 2 O 5 , 3 CeO 2 , 4 MoO 3 , 5 Au, 6 Ag, 7 Pd, 8 carbon-based materials, for example, carbon-dots (C-dots) 9 or graphene quantum dots, 10 Prussian Blue nanoparticles, 11 organic nanoparticles, such as melanin nanoparticles, 12 and metal–organic framework nanoparticles (NMOFs), such as Zr-based NMOFs 13 or MOF-818, 14 were reported as nanozymes. Different chemical transformations emulating native enzymes were demonstrated by synthetic nanozymes including oxidase, 15 peroxidase, 16 laccase, 17 catalase, 18 superoxide dismutase, 19 and hydrolase activities.…”

Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges

“…There are various nanomaterials based on noble metals such as gold [44][45][46][47][48][49][50][51][52][53][54][55], silver [56-61], platinum [62][63][64][65][66][67][68][69][70][71][72][73][74][75], Pd [76][77][78], and multi-metallic NPs which are known as peroxidase imitates and are utilized for antibodies, therapy, and biosensing.…”