Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation

Abstract

Unearthing and employment of healthy substitutes is now in demand to tackle a number of diseases due to the excessive repercussions of synthetic drugs. In this frame of reference pomegranate juice (PGJ) is a boon comprising of anthocyanins and hydrolysable tannins, known for its anti-oxidant and anti-inflammatory properties. Despite various documented roles of PGJ, there are no studies on antifibrotic potential in NDEA-induced mammalian liver fibrotic model. Hepatic fibrosis in rats was induced by the intra-peritoneal injection of NDEA (10 mlkg−1b.wt. of 1% NDEA) in two weeks. Biochemical, histopathological and ultra-structural studies were carried out on control, fibrotic and treated rats. The liver function indices and LPO were increased significantly by intoxication of NDEA. The antioxidant status was disturbed with the decrease in SOD, GST and catalase in the liver and membrane-ATPases as well. Histopathological observations by H&E, M&T, picro-sirius and ultra-structural scrutiny by SEM and TEM indicated liver damage and increase in COX2 and α-SMA by NDEA which was successfully rectified by the supplementation of PGJ. PGJ abrogates liver fibrosis instigated by NDEA in Wistar rats by declining oxidative stress via regulation of Nrf2 and NFκB. These findings point towards pomegranate as a potential and efficacious therapeutic agent against liver fibrosis.

Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S‐Mediated Noncanonical Mechanism

“…The protective role of NRF2 in liver fibrosis by ameliorating liver injury and inhibiting HSC activation has been reported previously . It is possible that the beneficial effects of SPD and NRF2 activation on ameliorating CCl 4 ‐induced liver fibrosis could be independent of the effects on HSCs.…”

The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure

“…These observations are most likely attributed to the presence of hydrolysable polyphenols, specifically ellagitannins, which were considered to be the most active antioxidants among the tannins contained therein. These compounds (elagic acid, punicalagin, punicalin and galagid acid) have been shown to have increased antioxidant and pleiotropic effects and are believed to act in synergy [59,60]. Our findings were found to be similar to studies of Husain et al [61] , Bachoual et al [62] and seem to be compatible with Esmaillzadeh et al [63] as they demonstrated that pomegranate juice significantly reduce the total cholesterol level.…”

Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats

“…5 ) provided clear evidence of organ toxicity, similar to those associated with known hepatotoxins and nephrotoxins. 52 , 54 , 55 , 56 It also provided the much needed correlation with observed changes in biochemical indices ( Table 3 ). However, differences in liver and kidney histology do not seem to follow a specific pattern for both single and 28 days of repeated doses.…”