Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients

Ghavipour, Mahsa; Sotoudeh, Gity; Tavakoli, E; Mowla, Karim; Hasanzadeh, Jafar; Mazloom, Zohreh

doi:10.1038/ejcn.2016.151

Cited by 108 publications

(75 citation statements)

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“…It has been suggested that the inhibitory effects of EA are greater than GA and PU on nitrite production (BenSaad et al, ). Moreover, EA protected the DNA double helix against different alkylating agents (Ghavipour et al, ; Khodadadi & Nasri, ).…”

Section: Resultsmentioning

confidence: 99%

“…POMx significantly reduced the score of DAS28 as an indicator of reducing tender joints, pain intensity, swelling, and erythrocyte sedimentation rate (ESR) levels after 8 weeks. Moreover, POMx meaningfully diminished the morning stiffness and HAQ score, while enhanced the level of GPx content and activity (Ghavipour et al, ). In another study, eight patients with active RA received pomegranate extract (10 mL daily) for 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

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Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

133

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Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

133

View full text Add to dashboard Cite

show abstract

“…The mechanism for the protective effect of tea on RA is still unclear. RA is a chronic inflammatory disease of the joints with systemic overproduction of pro-inflammatory cytokines such as IL-6 and TNF-α [21]. Tea contains EGCG, a potent anti-inflammatory molecule found in green, oolong and black tea that affects IL-6 activity and trans-signalling [22,23].…”

Section: Discussionmentioning

confidence: 99%

Tea Consumption Is Associated with Decreased Disease Activity of Rheumatoid Arthritis in a Real-World, Large-Scale Study

Jin¹,

Li²,

Gan³

et al. 2020

Ann Nutr Metab

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Introduction: The role of tea consumption on rheumatoid arthritis (RA) has been studied in recent years, but no clear conclusion has been drawn as a result of small sample size of the studies or the fact that only in vitro studies have been performed. Objectives: The aim of this study was to explore the possible association of tea consumption with RA through a large-scale, real-world study. Methods: A total of 733 RA patients were investigated from June to December, 2016. The disease activity of RA was assessed according to disease activity score 28-erythrocyte sedimentation rate. The amount and types of tea consumption were recorded by on-site self-administered questionnaires. Logistic regression models were applied to analyze the correlation between tea consumption and disease activity, adjusting for demographics, clinical and laboratory factors. Results: There was an inverse association between tea consumption and disease activity in RA patients (OR 0.66, 95% CI 0.46–0.94). Compared with non-tea drinkers, a higher-intake of tea (>750 mL/day) was associated with lower disease activity of RA (OR 0.39, 95% CI 0.19–0.79), but not low-intake (≤750 mL/day; OR 0.83, 95% CI 0.42–1.63). A significant dose-response association was found between the amount of tea consumption and disease activity (p for trend <0.01). Further hierarchical regression analysis showed that such inverse associations were mainly present in female patients (p = 0.004), non-smokers (p = 0.01) or elders (≥60 years; p = 0.01). Conclusion: Tea consumption is associated with decreased disease activity of RA, suggesting the potential beneficial effect of tea in the disease.

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“…Pomegranate (2 capsules of 250 mg pomegranate extract/day for 8 weeks) improved disease activity, some inflammatory blood biomarkers and oxidative stress (increased glutathione peroxidise) in 30 rheumatoid arthritis patients in a double-blind, placebo-controlled, randomized study [24].…”

Section: Clinical Studiesmentioning

confidence: 99%

Clinical Applications of Pomegranate

Elnawasany¹

2018

Breeding and Health Benefits of Fruit and Nut Crops

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Pomegranate, Punica granatum L., is an ancient, unique fruit borne on a small, long-living tree in the Mediterranean region, Southeast Asia, and tropical Africa. Pomegranate was mentioned in ancient times in the Old Bible, the Jewish Torah, and mentioned three times in the holy Quran where it was described as one of the paradise fruits. In ayurvedic medicine, pomegranate is used in the treatment of parasitic infection, diarrhea, and ulcers. Recently, pomegranate has been studied in several systems of medicine for its pharmacological actions: anti-inflammatory, antioxidant, and anticarcinogenic. The aim of the chapter is to summarize pomegranate efficacy in many preclinical and clinical studies.

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Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients

Abstract: POMx alleviates disease activity and improves some blood biomarkers of inflammation and oxidative stress in RA patients.

Cited by 108 publications

References 50 publications

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Tea Consumption Is Associated with Decreased Disease Activity of Rheumatoid Arthritis in a Real-World, Large-Scale Study

Clinical Applications of Pomegranate

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