Pomegranate juice ameliorates pulmonary fibrosis by regulating inflammatory response and epithelial mesenchymal transformation

Xia, Rui; Wang, Liqun; Zhou, Ting; Zeng, Yiting; Li, Xingjie; Wu, Shouxun; Huang, Xiaoyi; Kang, Yuhong; Yin, Wenya

doi:10.1016/j.jff.2022.105113

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Several studies showed increased CD8 + T cell expression in pulmonary fibrosis patients or mice injected with bleomycin [20]. In the second week, the highest production of the proinflammatory cytokine interleukin-6 (IL-6) secreted by CD8 + T cells in bleomycin-induced mice was found in the pulmonary fibrosis mice model (PF) group.…”

Section: Production Of Il-6 By Cd8 + (Cd8 + Il-6 + )mentioning

confidence: 99%

Tapak Liman (Elephantopus scaber L.) Leaves Ethanol Extract Improves the Production of IL-6 and IL-17 Cytokines in Mice with Bleomycin-induced Pulmonary Fibrosis

Nabilah,

Christina,

Dwijayanti

et al. 2024

JELS

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IL-6 and IL-17 are pro-inflammatory and pro-fibrotic cytokines that increase pulmonary fibrosis due to lung alveolar epithelial cell damage. Tapak liman leaves (Elephantopus scaber L.) have anti-inflammatory and anti-asthmatic properties. This study aimed to investigate the effects of the Elephantopus scaber L. ethanol extract (ESEE) on IL-6 and IL-17 produced by CD4 + and CD8 + in the bleomycin-induced pulmonary fibrosis mice model. Fifty-six male BALB/c mice will be divided into seven groups consisting of healthy mice (N), vehicle mice (V), pulmonary fibrosis (PF), Dexamethasone (DEX) as a drug control, and three doses of ESEE (0.0504, 0.1008, and 0.2016 mg.kg -1 BW). ESEE will be administered orally, followed by intraperitoneal bleomycin injection for 14 days. Mice are then dissected on days 7 and 14, and the spleen will be isolated for analysis of the expression of IL-6 and IL-17. The results showed that ESEE effectively reduced levels of IL-6 and IL-17 cytokines produced by CD4 + and CD8 + T cells, and doses three of ESEE (0.2016 mg.kg -1 BW) (0.2016 mg.kg -1 BW) showed the most effective reduction activity than the Dexamethasone group. The treatment was proven to reduce the expression of IL-6 and IL-17 in mice with a model of pulmonary fibrosis.

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Section: Production Of Il-6 By Cd8 + (Cd8 + Il-6 + )mentioning

confidence: 99%

Tapak Liman (Elephantopus scaber L.) Leaves Ethanol Extract Improves the Production of IL-6 and IL-17 Cytokines in Mice with Bleomycin-induced Pulmonary Fibrosis

Nabilah,

Christina,

Dwijayanti

et al. 2024

JELS

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“…The RRTE solution (8 mg/mL) was configured using methanol and filtered with a 0.22 organic filter membrane. Referring to our previous test parameters [24], we used liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) (Thermo Fisher, Germany) to determine the possible bioactive substances in RRTE. Visualization was achieved using Thermo Xcalibur Qual Browser and Origin 2022 software, matching and compositional analysis using Compound Discoverer 3.1.1.12 software in combination with mzVault database (Supplementary Table S1).…”

Section: Component Analysis Of the Rrtementioning

confidence: 99%

Rosa Roxburghii Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway

Li,

Ling,

Huang

et al. 2023

Nutrients

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Ulcerative colitis (UC) is a non-specific inflammatory bowel illness characterized by intestinal mucosal barrier degradation, inflammation, oxidative damage, and gut microbiota imbalances. Rosa roxburghii Tratt Fruit extract (RRTE) was extracted from Rosa roxburghii Tratt fruit, exhibiting an excellent prevention effect against UC; RRTE could prevent the damage of DSS-induced human normal colonic epithelial (NCM 460) cells, especially in cell viability and morphology, and oxidative damage. Additionally, in UC mice, RRTE could limit the intestinal mucosal barrier by increasing the expression of intestinal tight junction proteins and mucin, reducing inflammation and oxidative damage in colon tissue. More importantly, RRTE can increase the abundance of beneficial bacteria to regulate gut microbiota such as Ruminococcus, Turicibacter, and Parabacteroides, and reduce the abundance of harmful bacteria such as Staphylococcus and Shigella. Furthermore, transcriptomics of colonic mucosal findings point out that the beneficial effect of RRTE on UC could be attributed to the modulation of inflammatory responses such as the IL-17 and TNF signaling pathways. The qPCR results confirm that RRTE did involve the regulation of several genes in the IL-17 signaling pathway. In conclusion, RRTE could prevent DSS-induced damage both in vitro and in vivo.

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Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis

Mannino

Imbesi

Bitto

et al. 2023

Biomedicine & Pharmacotherapy

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Pomegranate juice ameliorates pulmonary fibrosis by regulating inflammatory response and epithelial mesenchymal transformation

Cited by 4 publications

References 42 publications

Tapak Liman (Elephantopus scaber L.) Leaves Ethanol Extract Improves the Production of IL-6 and IL-17 Cytokines in Mice with Bleomycin-induced Pulmonary Fibrosis

Tapak Liman (Elephantopus scaber L.) Leaves Ethanol Extract Improves the Production of IL-6 and IL-17 Cytokines in Mice with Bleomycin-induced Pulmonary Fibrosis

Rosa Roxburghii Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway

Anti-oxidant and anti-inflammatory effects of ellagic and punicic acid in an in vitro model of cardiac fibrosis

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