Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation

Aviram, Michael; Rosenblat, Mira; Gaitini, Diana; Nitecki, Samy; Hoffman, Aaron; Dornfeld, Leslie; Volkova, Nina; Presser, Dita; Attias, Judith; Liker, Harley; Hayek, Tony

doi:10.1016/j.clnu.2003.10.002

Cited by 558 publications

(432 citation statements)

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“…Because pomegranates are widely consumed and implicated with potential human health benefits [8,15], we have investigated the antiproliferative, apoptotic and antioxidant activities [lipid peroxidation inhibitory and Trolox equivalent antioxidative capacity (TEAC)] of its polyphenols. Pomegranate was evaluated in the form of PJ, a popularly consumed beverage, as a standardized total pomegranate tannin (TPT) extract (contains 85% punicalagin anomers, 1.3% EA, 12% minor ETs and EAGs) [13], and as its reported active ingredients, punicalagin and EA.…”

Section: Introductionmentioning

confidence: 99%

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice

Seeram

Adams

Henning

et al. 2005

The Journal of Nutritional Biochemistry

959

664

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Section: Introductionmentioning

confidence: 99%

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice

Seeram

Adams

Henning

et al. 2005

The Journal of Nutritional Biochemistry

959

664

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“…Altogether, the results of the above studies clearly demonstrate that PJ may be considered as a potent nutraceutical agent against CVD (36,37) .…”

Section: Pomegranatesmentioning

confidence: 63%

“…PJ not only inhibited LDL oxidation, but also reduced two other related modifications of the lipoprotein, that is, its retention to extracellular matrix proteoglycans and its susceptibility to aggregation. The inhibitory effects of PJ consumption on macrophage ability to oxidise LDL on the one hand, and on the uptake of oxidised LDL on the other, contributed substantially to the attenuation of cellular cholesterol accumulation and foam cell formation, as observed in atherosclerotic mice and in atherosclerotic patients (36) . PJ supplementation to E8 mice significantly reduced the number of macrophage foam cells and the size of the atherosclerotic lesion, in comparison to controls.…”

Section: Pomegranatesmentioning

confidence: 94%

“…PJ supplementation to E8 mice significantly reduced the number of macrophage foam cells and the size of the atherosclerotic lesion, in comparison to controls. PJ consumption by patients with carotid artery stenosis for 1 year reduced systolic blood pressure (by 18 %), oxidative stress (by 65 %) and, most importantly, the lesion size as measured by intima-media thickness (IMT; by , 30 %) (36) .…”

Section: Pomegranatesmentioning

confidence: 99%

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The Middle Eastern and biblical origins of the Mediterranean diet

Berry

Arnoni

Aviram³

2011

Public Health Nutr.

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Objective: To place the Mediterranean diet (MedDi) in the context of the cultural history of the Middle East and emphasise the health effects of some of the biblical seven species -wheat, barley, grapes, figs, pomegranates, olives and date honey. Design: Review of the literature concerning the benefits of these foods. Setting: Middle East and Mediterranean Basin. Subjects: Mediterranean populations and clinical studies utilising the MedDi. Results and conclusions: The MedDi has been associated with lower rates of CVD, and epidemiological evidence promotes the benefits of consuming fruit and vegetables. Recommended foods for optimal health include whole grain, fish, wine, pomegranates, figs, walnuts and extra virgin olive oil. The biblical traditional diet, including the seven species and additional Mediterranean fruits, has great health advantages, especially for CVD. In addition to the diet, lifestyle adaptation that involves increasing physical activity and organised meals, together with healthy food choices, is consistent with the traditional MedDi. The MedDi is a manageable, lifestyle-friendly diet that, when fortified with its biblical antecedent attributes, may prove to be even more enjoyable and considerably healthier in combating the obesogenic environment and in decreasing the risks of the non-communicable diseases of modern life than conventional, modern dietary recommendations. The biblical seven species, together with other indigenous foods from the Middle East, are now scientifically recognised as healthy foods, and further improve the many beneficial effects of the MedDi.

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“…Several laboratory and clinical studies have demonstrated the anti-inflammatory, antiatherosclerotic, anti-cancer, and anti-viral activities of pomegranate juice [3][4][5][6][7][8][9][10][11][12][13][59][60][61][62][63][64][65][66]. However, these studies still leave the question of whether these extraordinary health effects of pomegranate are the consequence of some unique properties of the pomegranate ingredients open to discussion.…”

Section: Resultsmentioning

confidence: 99%

Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics

Nicolson¹,

Veljković²,

Glišić³

et al. 2016

FFHD

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Citation: Veljkovic V.V., Glisic S., Perovic V., Veljkovic N., Nicolson G.L.. Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics. Health and Disease 2016; 6(12):769-787 ABSTRACT Background: Numerous in vitro and in vivo studies, in addition to clinical data, demonstrate that pomegranate juice can prevent or slow-down the progression of some types of cancers. Despite the well-documented effect of pomegranate ingredients on neoplastic changes, the molecular mechanism(s) underlying this phenomenon remains elusive. Functional Foods in Methods:For the study of pomegranate ingredients the electron-ion interaction potential (EIIP) and the average quasi valence number (AQVN) were used. These molecular descriptors can be used to describe the long-range intermolecular interactions in biological systems and can identify substances with strong electron-acceptor properties. In this study, candidate human proteins interacting with pomegranate flavonoids have been analyzed by the informational spectrum method (ISM). This represents a virtual spectroscopy method for studying protein molecular interactions.Results: Our analysis indicates that the anti-cancer properties of pomegranate juice can be ascribed to the strong electron-acceptor properties of its chemical ingredients. This analysis also suggests that pomegranate flavonoids inhibit the "NF-kappaB" (NF-κB) pathway, which plays a critical role in the pathogenesis of cancer. Conclusion:The results offer a possible explanation for an important molecular mechanism underlying the anticancer activity of pomegranate ingredients, which could also serve as a basis for the development of new therapeutic compositions of food supplements with pomegranatelike anticancer properties.Key words: cancer, pomegranate, flavonoids, food supplement, informational spectrum method BACKGROUND With more than 10 million new cases world-wide reported each year, cancer is one of the most devastating human diseases [1]. Despite progress in the understanding and treatment of these diseases including significant improvements in diagnostics and therapy based on applications of modern technology, the incidence and cure rates of various cancers, even in highly developed countries, have not improved significantly [2]. For this reason, increased attention has turned to complementary therapies, including natural dietary supplements. Among these natural agents, pomegranate (Punica granatum) juice has drawn a great deal of attention from both the scientific community and the general public due to its demonstrated ability to suppress cancers [3][4][5][6][7][8][9][10][11][12][13]. For example, pomegranate has been found to possess well-documented cancer chemopreventive and chemotherapeutic effects against prostate cancer [10][11][12][13]. The results of a Phase II clinical study of patients with rising prostate-specific antigen (PSA) levels following surgery or radiation ...

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Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation

Cited by 558 publications

References 45 publications

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice

The Middle Eastern and biblical origins of the Mediterranean diet

Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics

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