Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide

Ignarro, Louis J.; Byrns, Russell E.; Sumi, Daigo; Nigris, Filomena de; Napoli, Claudio

doi:10.1016/j.niox.2006.03.001

Cited by 145 publications

(126 citation statements)

References 38 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…39 Antioxidants can recouple endothelial NO synthase 39 and protect NO from destruction by these potent oxidants. 40 The complete reversal of the effect of smoking on NO by high daily doses of vitamins C (1000 mg) and E (800 IU) (Figure 2) demonstrates that even these weak antioxidants can effectively counteract oxidative stress, provided the doses are sufficiently high. 38 Besides efforts at quitting, early and aggressive supplementation with antioxidants may prevent ED and progressive vascular disease in these men.…”

Section: Smoking Cessationmentioning

confidence: 98%

See 1 more Smart Citation

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

View full text Add to dashboard Cite

Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been linked to abdominal obesity, smoking and high intakes of fat and sugar, which all cause oxidative stress. Men with ED have decreased vascular NO and circulating and cellular antioxidants. Oxidative stress and inflammatory markers are increased in men with ED, and all increase with age. Exercise increases vascular NO, and more frequent erections are correlated with decreased ED, both in part due to stimulation of endothelial NO production by shear stress. Exercise and weight loss increase insulin sensitivity and endothelial NO production. Potent antioxidants or high doses of weaker antioxidants increase vascular NO and improve vascular and erectile function. Antioxidants may be particularly important in men with ED who smoke, are obese or have diabetes. Omega-3 fatty acids reduce inflammatory markers, decrease cardiac death and increase endothelial NO production, and are therefore critical for men with ED who are under age 60 years, and/or have diabetes, hypertension or coronary artery disease, who are at increased risk of serious or even fatal cardiac events. Phosphodiesterase inhibitors have recently been shown to improve antioxidant status and NO production and allow more frequent and sustained penile exercise. Some angiotensin II receptor blockers decrease oxidative stress and improve vascular and erectile function and are therefore preferred choices for lowering blood pressure in men with ED. Lifestyle modifications, including physical and penile-specific exercise, weight loss, omega-3 and folic acid supplements, reduced intakes of fat and sugar, and improved antioxidant status through diet and/or supplements should be integrated into any comprehensive approach to maximizing erectile function, resulting in greater overall success and patient satisfaction, as well as improved vascular health and longevity.

show abstract

Section: Smoking Cessationmentioning

confidence: 98%

“…Pomegranate has been shown to increase endothelial NO and prevent its breakdown. 40 Chocolate has been extensively examined for its favorable vascular effects. 11 The effects of 22 g of cocoa with and without 45 g of sugar were examined on FMD.…”

Section: Excessive Alcoholmentioning

confidence: 99%

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Furthermore, considering oxidative modification hypothesis and role of Ox-LDL in atherosclerosis (Pirillo, Norata, & Catapano, 2013), many studies have been conducted on using various pomegranate-derived products as natural antioxidants to improve oxidative stress and decrease atherosclerosis risk factors. Invivo and in-vitro studies have demonstrated attenuating and protective influences of the pomegranate products on LDL oxidation and atherosclerosis (Aviram et al, 2000;Basu & Penugonda, 2009;Davidson et al, 2009;Fuhrman, Volkova, & Aviram, 2005Ignarro, Byrns, Sumi, De Nigris, & Napoli, 2006;Sezer, Akçay, Ilanbey, Yıldırım, & Sözmen, 2007) through various mechanisms, including induction of paraoxonase-1 (Aviram et al, 2004) and peroxisome proliferators activated receptor (Huang et al, 2005) activities as well as endothelial nitric-oxide synthase availability , and reduction of LDL aggregation (Aviram et al, 2000) and cellular uptake of oxidized LDL (Fuhrman et al, 2005). However, there is little information about direct effects of PSO on preventing LDL oxidation.…”

Section: Introductionmentioning

confidence: 99%

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Faisi

Fattahi

Raffel

et al. 2018

CyTA - Journal of Food

View full text Add to dashboard Cite

Effects of pomegranate seed oils extracted with supercritical fluid or cold press methods (SFE-PSO and CP-PSO), unsaponifiable (N), and fermented juice polyphenols (W) fractions of pomegranate as well as olive oil and alpha-tocopherol, as pure or in different solvents were evaluated on preventing copper-induced LDL oxidation. The results showed addition of pure SFE-PSO, CP-PSO, N fractions, and olive oil had no significant effect on LDL oxidation. Also using various solvents did not help in the term of extending the oxidation lag phase. However, adding 0.5, 1, 1.5, and 3 µL of the W solution in EtOH could delay the lag phase 103.5, 145.9, 200, and 199.1 min, respectively. There was no synergistic effect between W and N on inhibiting the oxidation. It can be concluded that polyphenolic fraction of pomegranate juice can act as antiatherogenic supplementation and natural preservative for meat and fatty foods through direct inhibition of LDL oxidation.Efectos del aceite de semilla de granada y la fracción polifenólica de jugo fermentado, mezclados con distintos solventes, en la oxidación de LDL inducida por cobre RESUMEN A efectos de prevenir la oxidación de LDL inducida por cobre, el presente estudio se propuso evaluar los efectos que los aceites de semilla de granada extraídos con fluido supercrítico o métodos de presión en frío (SFE-PSO y CP-PSO), y las fracciones polifenólicas de jugo de granada fermentado e insaponificable (N), así como el aceite de oliva y el alfa-tocoferol, tienen en estado puro o en distintos solventes. Los resultados mostraron que la adición de fracciones SFE-PSO, CP-PSO, N puras y aceite de oliva no produjo ningún efecto significativo en la oxidación de LDL. Por otra parte, el uso de varios solventes no contribuyó a extender la fase de latencia de la oxidación. Sin embargo, al agregar 0.5, 1, 1.5 y 3 µl de la solución W en EtOH se pudo retrasar la fase de latencia 103.5, 145.9, 200 y 199.1 minutos, respectivamente. No se produjo ningún efecto sinérgico entre W y N en la inhibición de oxidación. Por lo tanto, se concluye que la fracción polifenólica del jugo de granada puede actuar como suplemento antiaterogénico y conservador natural de carnes y alimentos grasos mediante la inhibición directa de la oxidación de LDL. ARTICLE HISTORY

show abstract

“…POM contains approximately 1.5% flavonoids, polyphenols, pectin and ascorbic acid by weight. 1 Antioxidants, such as those in POM, enhance the bioavailability of NO and offer protection against atherosclerosis. 1 Recent laboratory tests revealed that POM consumption in atherosclerotic apolipoprotein E-deficient mice reduced the size of atherosclerotic lesions by 44% and decreased low-density lipoprotein (LDL) susceptibility to aggregation and retention in humans.…”

Section: Introductionmentioning

confidence: 99%

“…1 Antioxidants, such as those in POM, enhance the bioavailability of NO and offer protection against atherosclerosis. 1 Recent laboratory tests revealed that POM consumption in atherosclerotic apolipoprotein E-deficient mice reduced the size of atherosclerotic lesions by 44% and decreased low-density lipoprotein (LDL) susceptibility to aggregation and retention in humans. 2 The protective effects of NO on atherosclerosis and oxidative destruction are attributed to its ability to prevent adhesion and aggregation of blood cells and platelets, inhibit vascular smooth muscle cell proliferation, and prevent oxidation of LDL cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study

Forest¹,

Padma‐Nathan²,

Liker

2007

Int J Impot Res

View full text Add to dashboard Cite

This randomized-controlled trial examined the efficacy of wonderful variety pomegranate juice versus placebo in improving erections in 53 completed subjects with mild to moderate erectile dysfunction. The crossover design consisted of two 4-week treatment periods separated by a 2-week washout. Efficacy was assessed using International Index of Erectile Function (IIEF) and Global Assessment Questionnaires (GAQ). Of the 42 subjects who demonstrated improvement in GAQ scores after beverage consumption, 25 reported improvement after drinking pomegranate juice. Further, 17 subjects showed preference of one beverage to the other. Subjects were more likely to have improved scores when pomegranate juice was consumed (P ¼ 0.058). Although overall statistical significance was not achieved, this pilot study suggests the possibility that larger cohorts and longer treatment periods may achieve statistical significance.

show abstract

Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide

Cited by 145 publications

References 38 publications

Lifestyle and metabolic approaches to maximizing erectile and vascular health

Lifestyle and metabolic approaches to maximizing erectile and vascular health

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study

Contact Info

Product

Resources

About