Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1

Abo-Saif, Mariam A.; Ragab, Amany E.; Ibrahim, Amera O.; Abdelzaher, Othman F.; Mehanyd, Ahmed B. M.; Saber-Ayad, Maha; El-Feky, Ola A.

doi:10.3389/fphar.2023.1166653

Cited by 21 publications

(16 citation statements)

References 69 publications

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“…For instance, there was a decrease in IL-6: 3.74 ± 1.08 pg/mL and IL-1β, 5.12 ± 1.24 pg/mL compared to the untreated diabetic groups: IL-6, 6.44 ± 1.98 pg/mL, p < 0.05 and IL-1β, 7.99 ± 1.23 pg/mL, p < 0.05. These results are further supported by Abo-Saif et al [ 43 ], who demonstrated a significant decrease in IL-1β following eight weeks of PPE at a 150 mg/kg dose in diabetic Wistar rats. El-Missiry et al [ 42 ] used the same model with an intraperitoneal punicalagin dose of 1 mg/kg for 15 days.…”

Section: Resultssupporting

confidence: 75%

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The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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Diabetes mellitus is recognized as the leading contributor to cardiovascular disease and associated mortality rates worldwide. Despite the use of pharmaceutical drugs to treat diabetes, its prevalence continues to rise alarmingly. Therefore, exploring remedies with a lower toxicity profile is crucial while remaining safe and effective in addressing this global public health crisis. Punica granatum Linn (pomegranate), known for its properties and safety profile, has been investigated in applied research and preclinical and clinical trials. However, conflicting reports still exist regarding its effects in diabetes. According to our knowledge, no systematic review has been conducted to critically analyze evidence from preclinical and clinical trials simultaneously, explicitly focusing on oxidative stress, inflammation, and endothelial function in diabetes. Therefore, in this systematic review, we searched for evidence on the impact of pomegranate in diabetes using databases such as PubMed, Scopus, and Google Scholar. Our inclusion criteria were limited to studies published in English. Of the 170 retrieved studies, 46 were deemed relevant and underwent critical analysis. The analyzed evidence suggests that pomegranate has the potential to alleviate oxidative stress, inflammation, and endothelial dysfunction in diabetes. Although a beneficial impact was noted in these markers, the endothelial function evidence still requires validation through further clinical trials with a powered sample size.

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Section: Resultssupporting

confidence: 75%

“…MDA levels were reduced in several preclinical studies [ 16 , 19 , 20 , 23 , 34 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 45 , 46 , 47 , 51 , 56 ]. Interestingly, similar findings were observed in clinical studies, as shown by a decrease in MDA levels [ 26 , 30 , 53 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

et al. 2023

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“…In DCM mice, the levels of NLRP3 and pyroptosis pathway-related proteins, as well as IL-18 and IL-1β, exhibited marked increases ( 69 ). Inhibiting NLRP3 inflammasome activation can ameliorate cardiac inflammation, pyroptosis, fibrosis, and left ventricular cardiac dysfunction ( 15 , 70 ). Besides, AIM2, as a cytosolic DNA sensor, mediates the development of DCM through the caspase 1/GSDMD pathway.…”

Section: Mechanisms Involved In Pyroptosis and Its Impact On Diabetic...mentioning

confidence: 99%

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

Li,

Zhang,

Wang

et al. 2023

Front. Endocrinol.

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Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing evidence, further investigation into the mechanisms by which exercise inhibits pyroptosis through the regulation of inflammasome pathways holds promising potential for expanding preventive and therapeutic strategies for DM and facilitating the development of novel therapeutic interventions.

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“…Pyroptosis is an inflammatory programmed cell death activated in response to microbial infection, cellular damage, or metabolic imbalances 21 . Oligomerization of NLRP3 inflammasome mediates the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 22 . Previous evidence suggests that NLRP3 inflammasome plays a vital role in the pathogenesis of cardiovascular diseases such as atherosclerosis, atrial fibrillation, and myocardial infarction 23 – 25 .…”

Section: Introductionmentioning

confidence: 99%

LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1

Zhang,

Sun,

Liu

et al. 2024

Sci Rep

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Considering the effect of SIRT1 on improving myocardial fibrosis and GAS5 inhibiting occurrence and development of myocardial fibrosis at the cellular level, the aim of the present study was to investigate whether LncRNA GAS5 could attenuate cardiac fibrosis through regulating mir-217/SIRT1, and whether the NLRP3 inflammasome activation was involved in this process. Isoprenaline (ISO) was given subcutaneously to the male C57BL/6 mice to induce myocardial fibrosis and the AAV9 vectors were randomly injected into the left ventricle of each mouse to overexpress GAS5. Primary myocardial fibroblasts (MCFs) derived from neonatal C57BL/6 mice and TGF-β1 were used to induce fibrosis. And the GAS5 overexpressed MCFs were treated with mir-217 mimics and mir-217 inhibitor respectively. Then the assays of expression levels of NLRP3, Caspase-1, IL-1β and SIRT1 were conducted. The findings indicated that the overexpression of GAS5 reduced the expression levels of collagen, NLRP3, Capase-1, IL-1β and SIRT1 in ISO treated mice and TGF-β1 treated MCFs. However, this effect was significantly weakened after mir-217 overexpression, but was further enhanced after knockdown of mir-217. mir-217 down-regulates the expression of SIRT1, leading to increased activation of the NLRP3 inflammasome and subsequent pyroptosis. LncRNA GAS5 alleviates cardiac fibrosis induced via regulating mir-217/SIRT1 pathway.

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Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1

Cited by 21 publications

References 69 publications

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies

Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1

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