Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms

Rahman, Md Mominur; Islam, Md Rezaul; Akash, Shopnil; Hossain, Md Emon; Tumpa, Afroza Alam; Abrar Ishtiaque, Galib Muhammad; Ahmed, Limon; Rauf, Abdur; Khalil, Anees Ahmed; Al Abdulmonem, Waleed; Simal-Gandara, Jesus

doi:10.1016/j.heliyon.2023.e18090

Cited by 6 publications

(7 citation statements)

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“…Similarly, fruit extracts of pomegranate have also shown in vitro and in vivo anticancer activities against skin and prostate cancer [38,[45][46][47]. The same extract showed in vivo antiproliferative activity against lung cancer [38,48], with similar activity being shown in aqueous peel extracts [49]. Likewise, leaf extracts have also shown in vitro signaling pathway inhibition activity against lung cancer [50].…”

Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 94%

“…In a recent study, phytocomplexes isolated from pomegranate through hydrodynamic cavitation showed selective in vitro antiproliferative activity against human breast cancer cell lines without causing harm to healthy cells [44]. Similarly, fruit extracts of pomegranate have also shown in vitro and in vivo anticancer activities against skin and prostate cancer [38,[45][46][47]. The same extract showed in vivo antiproliferative activity against lung cancer [38,48], with similar activity being shown in aqueous peel extracts [49].…”

Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 97%

“…A recent review on anticancer activities of pomegranate by Rahman et al [38] reported that extracts and pure compounds isolated from different parts of the plant have preventive and therapeutic activities against different types of cancers such as breast, skin, colon, bladder and lung cancers when tested at preclinical (in vitro and in vivo) and clinical levels. Similarly, galactomannan isolated from the fruit rind showed in vitro and in vivo anticancer activities against skin and lung cancers [38,39]. Other pomegranate phytochemicals such as luteolin, ellagic acid, and punicic acid have shown therapeutic activity against prostate cancer [40].…”

Section: Anticancer Activities Of Pomegranate Phytochemicalsmentioning

confidence: 99%

“…Furthermore, ellagic acid and urolithins A and B showed in vitro inhibition activity against breast cancer. In vitro and in vivo anticancer prevention activities have also been depicted in pomegranate phytochemicals like tannins and punicalagin against colon cancer [38].…”

Section: Anticancer Activities Of Pomegranate Phytochemicalsmentioning

confidence: 99%

“…Extracts from pomegranate seed oil and fermented fruit have shown in vitro therapeutic activity against breast cancer [38]. Peel extracts from pomegranate have shown in vitro radical scavenging and Fe 3+ antioxidant activities [43].…”

Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 99%

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Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)

O. Ochora,

Moodley,

Hayeshi

2023

Medicinal Plants - Harnessing the Healing Power of Plants

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Pomegranate (Punica granatum L.) is a Mediterranean plant that has been used in various countries for the treatment of various diseases in traditional medicine for many generations. These reported medicinal properties of pomegranate are mainly attributed to the presence of various phytochemical compounds in the plant. Scientific literature search was done in PubMed and Google Scholar databases. Full articles published in English for the last 25 years were selected. Pomegranate juice is the widely studied product of a plant. This is because of its wide medicinal and dietary use. Approximately 500 pure compounds have been isolated and characterized from different parts of the plant species. Phytochemically, the juice, seeds, flowers, and peels of P. granatum are the most studied parts of the plant. Major phytochemical compounds isolated from the plant include alkaloids, flavonoids, phenolics, tannins, sterols, and terpenes. Most of the compounds isolated from P. granatum belong to ellagitannins (punicalagins) and gallotannins. Medicinally, the use of different parts of pomegranate for the treatment of different types of cancer and cardiovascular diseases is the most widely reported in both preclinical and clinical researches. The herb/food-drug interactions of pomegranate juice with approved drugs have shown that pomegranate juice has the potential to inhibit some drugs, especially those metabolized by cytochrome CYP3A and CYP2C9. The current chapter gives a broad overview of the phytochemical, pharmacological, and herb/food-drug interactions of pomegranate.

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Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 94%

Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 97%

Section: Anticancer Activities Of Pomegranate Phytochemicalsmentioning

confidence: 99%

Section: Anticancer Activities Of Pomegranate Phytochemicalsmentioning

confidence: 99%

Section: Anticancer Properties Of Extracts From Pomegranatementioning

confidence: 99%

See 3 more Smart Citations

Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)

O. Ochora,

Moodley,

Hayeshi

2023

Medicinal Plants - Harnessing the Healing Power of Plants

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Anthocyanins from pomegranate peel (Punica granatum), chili pepper fruit (Capsicum annuum), and bougainvillea flowers (Bougainvillea spectabilis) with multiple biofunctions: Antibacterial, antioxidant, and anticancer

Abdelrahman,

Abdel Ghany,

Saber

et al. 2024

Heliyon

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The nutritional effect of aqueous extracts of coconut and pomegranate fruits in silkworm (Bombyx mori L.) with the toxic impact of green synthesis of zinc oxide nanoparticles

Elyamani,

Abd-Elmonem,

EL-Shafey

et al. 2024

Preprint

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Background Silkworm (Bombyx mori L.) is an imperative basis of the silk assembly in Egypt. The foundation of first-class silk is the foremost establishment in the sericulture diligence through a refining of the quality silk threads. The botanic extracts are used in the sustenance of silkworms to advance their creation. Coconut and pomegranate fruits enclose several antioxidant amalgams. However, nano-plants are the modern manner in the agrarian claims for crop protection. We need an inventive tactic to protect silkworms from any noxious residues. The existing study was designed to gauge the impacts of aqueous extracts of coconut, pomegranate, and zinc oxide nanoparticles derived from coconut and pomegranate extracts in the silkworms (Bombyx mori L.) at fifth instar larvae via scrutinizing of the biochemical and histopathological evaluations at 1% concentration after 72 h. Results Our records indicated that zinc oxide nanoparticles synthesized by coconut and pomegranate extracts induced a disturbance in the activities of aspartate transaminase, alanine transaminase, phenol oxidase, and total protein concentration compared to the control treatment, (P < 0.001). Also, some histopathological repetitions persuaded in the silkworms, such as a disorganization in the silk gland and an apoptotic appearance zone in the silk glands, and also no formed cocoon. Still, the aqueous extracts of coconut and pomegranate convinced no significant variation in biochemical factors and histological architecture of the silkworm with a formation of a decent appearance cocoon. Conclusions To sum up, this investigation revealed that the lethal effect of green synthesis of zinc oxide nanoparticles from coconut and pomegranate and the promising nutritional use of coconut and pomegranate extracts in the silkworm feeding. Lastly, this research exhibited that the negative influence of nanotechnology on the physiological manners of the silkworms and the positive influence of the natural plants on them. Thus, progresses in the silk production are required to further augment by using of plant extracts as nutritive source to silkworms.

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Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms

Cited by 6 publications

References 233 publications

Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)

Phytochemistry, Pharmacological Activities, and Drug Interactions of Pomegranate, Punica granatum L. (Punicaceae)

Anthocyanins from pomegranate peel (Punica granatum), chili pepper fruit (Capsicum annuum), and bougainvillea flowers (Bougainvillea spectabilis) with multiple biofunctions: Antibacterial, antioxidant, and anticancer

The nutritional effect of aqueous extracts of coconut and pomegranate fruits in silkworm (Bombyx mori L.) with the toxic impact of green synthesis of zinc oxide nanoparticles

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