Poncet's disease with high titers of rheumatoid factor and anti-citrullinated peptide antibodies mimicking rheumatoid arthritis

Sasaki, Hirokazu; Inagaki, Masako; Shioda, Mikio; Nagasaka, Kenji

doi:10.1016/j.jiac.2014.07.015

Cited by 14 publications

(19 citation statements)

References 44 publications

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“…Despite the convincing data for the relationship between BHSP65 and experimental arthritis in rodents, the causative role of BHSP65 in human RA remains unproven. We suspect that the case reported by Sasaki et al [ 6 ] of PD with positive RF and ACPA serology may have also eventually progressed to RA if monitored for a similar or longer period of time. The absence of TB infection and the absence of predictive features may have limited the progression to RA within the period reported by Sasaki et al [ 6 ].…”

Section: Discussionmentioning

confidence: 92%

“…In contrast, the ACPA status is less often reported and was negative in a few case reports that documented its status. There is, however, a single case of PD that has reported high titres of RF and ACPA, which mimicked rheumatoid arthritis [ 6 ]. This case did not report the duration of follow-up after resolution of arthritis or whether there was progression to rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

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Poncet’s Disease in the Preclinical Phase of Rheumatoid Arthritis

Nyo

Ally

Duuren

et al. 2018

Case Reports in Rheumatology

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We report on a patient with seropositive polyarthritis retrospectively diagnosed as Poncet's disease in the preclinical phase of seropositive rheumatoid arthritis. Our patient developed rheumatoid arthritis more than 2 years after being successfully treated for pulmonary tuberculosis and an initial inflammatory polyarthritis consistent with the diagnosis of Poncet's disease. This case illustrates the importance of recognizing Poncet's disease in a patient presenting with polyarthritis in order to avoid inappropriate long-term disease modifying antirheumatic treatment. It also illustrates the need for adequate follow-up of patients with Poncet's disease after treatment with antituberculosis treatment so that progression to a primary inflammatory arthritis such as rheumatoid arthritis may be identified timeously. Although seropositivity for rheumatoid arthritis has been reported in Poncet's disease as well as in tuberculosis, it is rather uncommon, and long-term follow-up of patients with Poncet's disease is essential particularly if they have positive serological tests for rheumatoid arthritis. In this case report, we describe the first reported case of Poncet's disease in the preclinical phase of rheumatoid arthritis and review the literature related to this rare disease presentation.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Poncet’s Disease in the Preclinical Phase of Rheumatoid Arthritis

Nyo

Ally

Duuren

et al. 2018

Case Reports in Rheumatology

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“…Aside from the abovementioned diseases, some light could also be shed from infections affecting the lung and from oral/nasal vaccination, respectively. In this context, tuberculosis can give rise to a false-positive ACPA test (84,85) and this has also been observed in Poncet's disease (86) and in the setting of leishmaniasis (87). Different vaccinations are also known to trigger transient RF (88) as can smoking (89).…”

Section: Ra-associated Autoimmunity and Secondary Localization To Thementioning

confidence: 99%

Mechanisms involved in triggering rheumatoid arthritis

Catrina

Joshua

Klareskog

et al. 2015

Immunological Reviews

136

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Rheumatoid arthritis (RA) is a chronic inflammatory syndrome with a strong autoimmune component. The autoantigens in RA are neither tissue nor organ-specific, but comprise a broad collection of post-translational modified proteins, such as citrullinated proteins. These modifications are likely to be triggered by innate stimuli. In genetically susceptible hosts, they can lead to a more substantiated secondary autoimmune reaction targeting the joints and precipitating the clinical onset of RA. Both innate and adaptive mechanisms will then closely interplay to promote chronic joint inflammation in the several absence of appropriate treatment. This scenario, is shared with other autoimmune diseases where potentially pathogenic immune responses are present already before disease onset. Better understanding of these processes will allow both earlier diagnosis of RA and identification of those healthy individuals that are at risk of developing disease, opening possibilities for disease prevention. In this review, we discuss the iterative processes of innate and adaptive immunity responsible for the (longitudinal) development of immune reactions that may contribute to the development of RA.

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“…However, Poncet disease, a rare condition in itself, is usually known to present with polyarthritis. 9 Definitive laboratory diagnosis of EPTB has always been a challenge, as appropriate specimens from extrapulmonary sites are usually difficult to obtain. Though microscopy and culture remain the cornerstones of laboratory diagnosis of TB, their sensitivity is quite low.…”

Section: Discussionmentioning

confidence: 99%

Acute Monoarthritis of the Wrist Joint: Tuberculosis or Not?

et al. 2015

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Extrapulmonary tuberculosis (EPTB) is known to have many and varied presentations. Extraspinal tuberculous osteomyelitis is rare and comprises only 2 to 3% of all cases of osteoarticular TB, with the hip and knee joints being the most commonly involved.Isolated involvement of bone with tubercular infection is uncommon. The clinical features of such infections are known to mimic chronic pyogenic osteomyelitis, Brodie abscess, or tumors, but not monoarthritis. An extensive literature review did not show any published report of tuberculous osteomyelitis presenting as acute monoarthritis of the wrist joint.We describe an unusual case of tuberculous osteomyelitis that mimicked features of acute monoarthritis of the wrist joint. This case underlines the importance of making EPTB an important differential diagnosis even in cases with clinical features that are completely inconsistent with tubercular infections. Case ReportA 28-year-old woman presented to the orthopedics department of a local hospital with complaints of pain in the right wrist joint along with stiffness of the joint since 1 month previously. On examination, there was swelling and tenderness around the joint. There was no axillary, supratrochlear, or epitrochlear lymphadenopathy. Skin lesions and ocular signs were not present. With no history of trauma, she was in good general condition. There was also no history of fever, weight loss, or loss of appetite. Laboratory testing showed no abnormalities in hemoglobin and uric acid levels, erythrocyte sedimentation rate, C-reactive protein, and leukocyte counts. Serum was negative for rheumatoid factor, antistreptolysin O, and antinuclear antibody). Blood cultures were sterile. X-ray of right distal forearm and wrist joint showed no abnormalities. With a Keywords ► monoarthritis ► wrist ► tuberculosis AbstractBackground Extrapulmonary tuberculosis (EPTB) is known to have many and varied presentations. However, isolated involvement of bone with tubercular infection is uncommon. The clinical features of such infections are known to mimic chronic pyogenic osteomyelitis, Brodie abscess, or tumors, but not acute monoarthritis. Case Description We describe here an unusual case of tuberculous osteomyelitis that mimicked features of acute monoarthritis of the wrist joint. Literature Review Extraspinal tuberculous osteomyelitis is rare and comprises only about 2 to 3% of all cases of osteoarticular tuberculosis, with the hip and knee joints being the most commonly involved. An extensive literature review did not show any published report of tuberculous osteomyelitis presenting as acute monoarthritis of the wrist joint. Clinical Relevance This case underlines the importance of making EPTB an important differential diagnosis even in cases with clinical features that are completely inconsistent with tubercular infections.

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Poncet's disease with high titers of rheumatoid factor and anti-citrullinated peptide antibodies mimicking rheumatoid arthritis

Cited by 14 publications

References 44 publications

Poncet’s Disease in the Preclinical Phase of Rheumatoid Arthritis

Poncet’s Disease in the Preclinical Phase of Rheumatoid Arthritis

Mechanisms involved in triggering rheumatoid arthritis

Acute Monoarthritis of the Wrist Joint: Tuberculosis or Not?

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