Pool walking may improve renal function by suppressing the renin-angiotensin-aldosterone system in healthy pregnant women

Abstract

This study aimed to examine the effect of pool walking on renal function in pregnant women. Fifteen pregnant women (mean gestational age, 37.8 weeks) walked in a pool (depth 1.3 m) for 1 h. A few days later, they walked on a street for 1 h. Within each activity, the starting and ending levels of plasma renin activity were measured. The total urine volume, creatinine clearance, and change in plasma renin activity levels between each activity were compared by Wilcoxon rank-sum test. The renin-angiotensin-aldosterone level was suppressed during pool walking: the mean starting and ending values of plasma renin activity and serum aldosterone were 6.8 vs. 5.5 ng/mL/h (p = 0.002) and 654 vs. 473 pg/mL (p = 0.01), respectively. The decreases in plasma renin activity and serum aldosterone levels were more evident in pool walking than in land walking (plasma renin activity, −1.27 vs. 0.81 ng/mL/h, p = 0.002; serum aldosterone, −180.9 vs. 3.1 ng/mL/h, p = 0.03), resulting in higher total urine volume (299 vs. 80 mL, p < 0.001) and creatinine clearance (161.4 vs. 123.4 mL/min, p = 0.03) in pool walking. Pool walking may improve renal function in pregnant women partly through the suppressed renin-angiotensin-aldosterone system.

Heated tobacco product use and hypertensive disorders of pregnancy and low birth weight: analysis of a cross-sectional, web-based survey in Japan

“… 11 12 Although the biological and genetic pathways (eg, CYP2A6 and nicotine) underlying the associations observed in different phenotypes of HDP (eg, pre-eclampsia and gestational hypertension) have not been elucidated, 20 HDP is recognised as a systemic disease attributable to placental circulatory dysfunction. 21 In experimental research, aerosol from HTPs was found to damage vascular endothelial function in rats. 6 Therefore, the association between HDP risk and HTP use may involve acute and chronic vascular damage, irrespective of combustible cigarette smoking.…”

Use of heated tobacco products may be associated with hypertensive disorders of pregnancy and low birth weight in Japan: An analysis of the JACSIS study

“…[20] Although the biological and genetic pathways (e.g., CYP2A6 and nicotine) underlying the associations observed in different phenotypes of HDP (e.g., preeclampsia and gestational hypertension) have not been elucidated, [21] HDP is recognized as a systemic disease attributable to placental circulatory dysfunction. [22] In experimental research, aerosol from HTPs was found to damage vascular endothelial function in rats. [5] Therefore, HDP risk associated with HTP use may involve acute and chronic vascular damage, irrespective of combustible cigarette smoking.…”