Pooled evidence from preclinical and clinical studies for stem cell-based therapy in ARDS and COVID-19

Murugan, Dhanashree; Rangasamy, Loganathan

doi:10.1007/s11010-022-04601-2

Cited by 2 publications

(2 citation statements)

References 119 publications

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“…More critically, there is no effective treatment for ARDS, a condition that develops and progresses rapidly and has high mortality [ 200 ]. For this reason, most of the clinical studies exploring the use of MSCs or their derivatives are conducted in ARDS patients [ 200 , 201 ]. However, these studies were carried out with a relatively small number of enrolled patients.…”

Section: Discussionmentioning

confidence: 99%

Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

Jerkić

Szászi

Laffey

et al. 2023

IJMS

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Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) have secretory, immunomodulatory, and tissue-reparative properties and have shown promise in acute and chronic inflammatory lung diseases and in COVID-19. Many beneficial effects of MSCs are mediated through their interaction with resident alveolar and pulmonary interstitial Mφs. Bidirectional MSC-Mφ communication is achieved through direct contact, soluble factor secretion/activation, and organelle transfer. The lung microenvironment facilitates MSC secretion of factors that result in Mφ polarization towards an immunosuppressive M2-like phenotype for the restoration of tissue homeostasis. M2-like Mφ in turn can affect the MSC immune regulatory function in MSC engraftment and tissue reparatory effects. This review article highlights the mechanisms of crosstalk between MSCs and Mφs and the potential role of their interaction in lung repair in inflammatory lung diseases.

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Section: Discussionmentioning

confidence: 99%

Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

Jerkić

Szászi

Laffey

et al. 2023

IJMS

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“…Following that, we searched for articles related to COVID-19. It has been found that the aetiology, pathology, transmission, treatment and consequences of COVID-19 had been well-published in the current literature (Murugan & Rangasamy, 2022;Nontawong et al, 2022;Qu et al, 2020;Valdes et al, 2022). Managing COVID-19 and reducing its harm had absorbed substantial medical resources and the energy of hospital managers (Ding & Zhao, 2021).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Nurse managers' experience during the COVID‐19 pandemic in China: A qualitative study

Chen,

Jiang,

Shen

et al. 2023

Nursing Open

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AimsThe aim of the study was to explore the experiences of female new nurse managers during the COVID‐19 pandemic.DesignThis was a phenomenological study, and qualitative descriptive analysis was used.MethodsNew nurse managers were defined as new nurse managers with less than 3 years of management experience in this study. During November and December of 2021, 18 female new nurse managers were interviewed face‐to‐face with a semi‐structured interview guide in three municipal hospitals. The study followed the Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines for evaluating qualitative research reports. Data analysis was performed using Colaizzi's seven‐step method.ResultsFour main themes and 10 sub‐themes were extracted from the collected data. The four major themes were as follows: (1) a shift in stress; (2) work‐related physical and psychological discomfort; (3) reflection on the cause; (4) coping and struggles.ConclusionsNew nurse managers were experiencing great stress and exhaustion in their roles. It is important that they are helped to handle situations. Providing them with readily accessible support, addressing their psychosocial needs and addressing exhaustion is necessary. Considering their short management time, the hospital should provide adequate support in human, financial and material areas and provide training to help new nurse managers better adapt to their new roles. In addition, nurse directors should create a culture of mutual respect, identify workplace bullying and create a harmonious and cooperation‐oriented work environment for new nurse managers.Patient or Public ContributionNo patient or public contribution.

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Pooled evidence from preclinical and clinical studies for stem cell-based therapy in ARDS and COVID-19

Cited by 2 publications

References 119 publications

Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

Nurse managers' experience during the COVID‐19 pandemic in China: A qualitative study

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