Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Li, Juan; Li, Sun; Sun, Jing; Yan, Min

doi:10.1186/s12881-019-0896-6

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…However, we did not observe any predisposition among all three VDR gene polymorphisms in our study. Although our results contradict the results of Kaya [ 38 ] and Dayangac-Erden [ 37 ], our results are consistent with the meta-analysis results of Li et al [ 43 ].…”

Section: Discussionsupporting

confidence: 70%

“…VDR A pa I polymorphism has been reported to be associated with psoriasis in Korea [ 34 , 35 ], China [ 36 ], and the Turkish population [ 37 , 38 ], while that in Japan [ 39 ], Italy [ 40 ], Croatia [ 41 ] or Egypt [ 42 ] it has not been recognized as a risk factor for psoriasis cases. Li et al [ 43 ] reported that VDR rs7975232 polymorphism did not have a significant effect on susceptibility to psoriasis in their meta-analysis evaluating the VDR rs7975232 polymorphism and psoriasis susceptibility of 13 case-control studies with 1,654 cases and 1,991 controls. In the same study, it was shown that VDR B sm I polymorphism was not associated with susceptibility to psoriasis in 13 studies involving 1,620 cases and 2,001 controls.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Albayrak¹,

Fazlıoǧlu²,

Batar³

et al. 2022

pdia

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Introduction Although psoriasis and obstructive sleep apnea syndrome (OSAS) are associated with systemic inflammation, studies on their potential bilateral relationship are not sufficient. Aim To investigate vitamin D levels and receptor gene polymorphisms in patients with OSAS and psoriasis and the associations with these diseases. Material and methods One hundred thirty-seven patients included in the study consisted of 4 different groups: group 1, those with both diseases; group 2, those with OSAS only; group 3, patients with psoriasis only; and group 4, healthy controls. The patients’ serum calcium, phosphorus, AHI, Epworth Sleepiness Scale, Psoriasis Area Severity Index, and VDR TagI, A pa I, Bs m I polymorphisms were compared. Results Vitamin D levels of groups 1, 2 and 3 were found to be lower than in controls. There was no statistically significant correlation between VDR TagI, A pa I, B sm I gene polymorphisms of the groups. Vitamin D levels were significantly higher in patients with heterozygous A pa I genotype (A/C) compared to patients with normal (A/A) or homozygous mutant (C/C) genotype ( p < 0.05). No relationship was determined between VDR TagI, A pa I, B sm I, and the other parameters. Conclusions In our study, 1,25(OH) 2 -vitamin D 3 levels were significantly lower in all disease groups compared to the control group. Although there is no difference between the groups in terms of VDR gene polymorphism, we think that there may be a bidirectional relationship between these diseases based on the low vitamin D levels.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Albayrak¹,

Fazlıoǧlu²,

Batar³

et al. 2022

pdia

View full text Add to dashboard Cite

show abstract

“…On the other hand, Li et al . [ 42 ] failed to find a relation between VDR gene polymorphisms and susceptibility to psoriasis…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor expression in chronic plaque psoriasis before and after narrowband ultraviolet B phototherapy

Elgarhy

El‐Tatawy

Rizk

et al. 2023

JCAS

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Background/Purpose: Psoriasis is a multifactorial disease. It is a combination of genetic, immunological, and environmental factors. Vitamin D receptor (VDR) is a nuclear receptor that regulates epidermal cell growth through the inhibition of proliferation and induction of keratinocytes terminal differentiation. Aim of the study was to investigate the effect of Narrow-band UVB (NB-UVB) therapy on VDR expression in the skin of psoriasis patients. Materials and Methods: Forty patients with different severities of psoriasis were assessed using the psoriasis area and severity index (PASI) score. Lesional and non-lesional skin biopsies were obtained from each patient before NB-UVB therapy, and then a third lesional biopsy was performed after completing 24 sessions of NB-UVB. Immunohistochemistry for VDR was performed on all specimens. Results: There was a significant decrease in VDR expression in psoriatic lesions compared to that in non-lesional skin before treatment. A statistically negative correlation was detected between the degree of VDR expression before treatment and PASI score, family history, and duration of psoriasis. There was a significant increase in VDR expression at the sites of psoriasis lesions post-NB-UVB therapy compared to pretreatment lesional skin. Conclusion: VDR expression was down-regulated in psoriatic lesions compared to non-lesional skin, and NB-UVB therapy improved VDR expression in psoriasis skin lesions.

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“…It is caused by the same complex interplay between genetic and environmental factors as other autoimmune conditions [57]. A metaanalysis [58] analyzed the results of 18 case-control studies. ApaI, BsmI, FokI, and TaqI SNPs were not associated with psoriasis susceptibility, but the authors stated that more case-control studies are needed to shed light on VDR SNPs involvement with psoriasis.…”

Section: Psoriasismentioning

confidence: 99%

VDR Gene Single Nucleotide Polymorphisms and Autoimmunity: A Narrative Review

Agliardi

Guerini

Bolognesi

et al. 2023

Biology

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The vitamin D/Vitamin D receptor (VDR) axis is crucial for human health as it regulates the expression of genes involved in different functions, including calcium homeostasis, energy metabolism, cell growth and differentiation, and immune responses. In particular, the vitamin D/VDR complex regulates genes of both innate and adaptive immunity. Autoimmune diseases are believed to arise from a genetic predisposition and the presence of triggers such as hormones and environmental factors. Among these, a role for Vitamin D and molecules correlated to its functions has been repeatedly suggested. Four single nucleotide polymorphisms (SNPs) of the VDR gene, ApaI, BsmI, TaqI, and FokI, in particular, have been associated with autoimmune disorders. The presence of particular VDR SNP alleles and genotypes, thus, was observed to modulate the likelihood of developing diverse autoimmune conditions, either increasing or reducing it. In this work, we will review the scientific literature suggesting a role for these different factors in the pathogenesis of autoimmune conditions and summarize evidence indicating a possible VDR SNP involvement in the onset of these diseases. A better understanding of the role of the molecular mechanisms linking Vitamin D/VDR and autoimmunity might be extremely useful in designing novel therapeutic avenues for these disorders.

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Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis

Cited by 5 publications

References 28 publications

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Vitamin D receptor expression in chronic plaque psoriasis before and after narrowband ultraviolet B phototherapy

VDR Gene Single Nucleotide Polymorphisms and Autoimmunity: A Narrative Review

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