Poor codon optimality as a signal to degrade transcripts with frameshifts

Abstract

11Living organisms are error-prone. Every second a single human cell produces over 100 12 transcripts with a substitution, frameshift or splicing error. Multiple mRNA quality control (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/345595 doi: bioRxiv preprint first posted online Jun. 13, 2018; the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here 26 we present computational evidence that these pathways are synergic for removing 27 frameshifts.