This study seeks to examine the relationship between the different urban land use activities in the Kumba metropolis and the related implications on the Kumba river water quality. This involved collection of water samples from the Kumba river as well as performing laboratory tests to determine variations in the river's Physical, chemical and bacteriological properties. The parameters analyzed were temperature, dissolved oxygen, total dissolved solids, total suspended solids, Electrical Conductivity, odour, colour, turbidity, nitrite, nitrate, pH, biochemical oxygen demand (BOD), chemical oxygen demand (COD), ammonia, phosphorus, chlorine, nitrates, nitrites and some heavy metals like copper, phosphate, iron, zinc, calcium, magnesium and Faecal Coliform. Water samples were collected from five sampling points in the month of February 2023(peak dry season) and in the month of April 2023(for the rainy season). The data from the analysis of the water samples were analyzed using both descriptive and inferential statistics, on both Microsoft Excel and SPSS. The study found that the p values were less than 0.05 at a confidence level of 95%, which suggests that the Kumba River is polluted due to the effects of different urban land use activities in the city. The water quality parameters of the collected samples showed that areas with high dependence on the river for urban activities registered significantly poor water quality, compared to samples with limited dependence on the river for urban land uses. Based on these findings, it is recommended that anthropogenic activities within the area be closely monitored as urbanization continues to rapidly occur and its effects continue to pollute the river, making it harmful not only to ecosystems but also rendering it unfit for river channel crop cultivation. Additionally, the study concluded that changes in Land Use Land Cover (LULC) between 2007 and 2023 have statistically significant effects on the physicochemical and microbial water quality of the Kumba River. Therefore, it is vital to address the rate at which forests are being converted to agricultural lands and the intense use of agrochemicals on these farms and plantations.