Poor nutritional status prior to peripheral blood stem cell transplantation is associated with increased length of hospital stay

Abstract

Summary:The nutritional status of patients prior to peripheral blood stem cell transplantation (PBSCT) and its impact on length of hospital stay is not well described in the literature. The nutritional status of 66 consecutive patients (46 m:20 f); and the mean age 58.7712.0 years was determined a maximum of 2 weeks pre-transplantation using the scored Patient-Generated-Subjective Global Assessment (PG-SGA). According to the global assessment, 73% patients were well nourished, 23% moderately malnourished and 4% severely malnourished. There was a significant difference in post transplant length of stay (mean difference7s.e.m. À7.072.1 days) between wellnourished and malnourished patients and a trend towards higher mortality in the malnourished group (2 vs 20%). Although 89% of patients described no problems eating, two or more nutrition impact symptoms were reported in 30% of patients. From stepwise multiple regression analysis, nutritional status as determined by PG-SGA score was significantly associated with length of stay, accounting for 12% of the variance. In conclusion, malnutrition prior to PBSCT is associated with increased length of stay. Routine nutrition assessment of patients prior to PBSCT should be undertaken.

Malnutrition among gynaecological cancer patients

“…The patient-generated SGA (PG-SGA) is a further modification of the SGA and has been specifically developed for patients with cancer (Ottery, 1996). The PG-SGA has been used for nutritional assessment in patients with various types of cancer such as cancer of the oesophagus, stomach, pancreas, lung, colorectum, breast and head and neck (Bauer et al, 2002;Persson et al, 2002;Isenring et al, 2003;Ravasco et al, 2003Ravasco et al, , 2005Bauer and Capra, 2005;Desbrow et al, 2005;Horsley et al, 2005;Segura et al, 2005). Bauer et al (2002) compared the scored PG-SGA with the SGA for patients with cancer and suggested the PG-SGA be used for further studies to detect malnutrition in cancer populations.…”

A.S.P.E.N. Clinical Guidelines: Nutrition Support Therapy During Adult Anticancer Treatment and in Hematopoietic Cell Transplantation

“…Rationale: HCT patients are predisposed to developing malnutrition because of their underlying disease, the conditioning regimen, and other treatment-related toxicities. 139,[143][144][145] Increase in morbidity 139,143,145 and mortality 145 has been reported in malnourished patients receiving HCT. Alterations in nutrition status persist long after transplantation, with as many of 50% of patients not returning to pre-transplant weight at 1 year.…”

Poor oral nutrition after allogeneic stem cell transplantation correlates significantly with severe graft-versus-host disease

“…3 It has previously been shown that poor nutritional status before SCT may prolong hospital stay. 4 In critically ill patients, parenteral nutrition (PN) has been associated with mucosal atrophy and an increased risk of infectious complications. 5 PN may also change the local cytokine production profile, resulting in low levels of interleukin (IL)-4 and IL-10.…”