Poor oral health status and adverse COVID‐19 outcomes: A preliminary study in hospitalized patients

Vilela, Ana Carolina Serafim; Costa, Camila Alves; Gomes, Tiago Dias; Andrade, Alex Alves Costa; Leles, Cláudio Rodrigues; Costa, Nádia Lago

doi:10.1002/jper.21-0624

Cited by 31 publications

(33 citation statements)

References 50 publications

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“…The oral cavity is a potential reservoir for respiratory pathogens, predisposing patients to secondary bacterial infection. Different studies state that there is an inverse correlation between oral health and the severity of Covid-19, the amount of CRP protein, and the recovery period of the disease (17 The result of the study showed that there is a positive relationship between oral and dental diseases, especially periodontitis, and the severe consequences of Covid-19, which was in line with our results (34). In 2021, Tamimi et al investigated 568 patients suffering from severe complications of Covid-19 in a case-control study using electronic health records in Qatar.…”

Section: Discussionsupporting

confidence: 90%

Whether misuse the oral hygiene may facilitate the speared of Covid 19 among cohabiting individual?

Bashardoust

mahmoudzadeh

Khoshtarash

et al. 2022

Preprint

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Background Despite all the existing guidelines regarding Covid-19, there has been less emphasis on oral care to reduce the amount of virus in the mouth and saliva and thus reduce the risk of transmission of this disease. The purpose of this study is to investigate oral hygiene habits and infection control behaviors and their relationship with the rate of family transmission in patients with covid-19. Methods In this cross-sectional analytical study, 179 patients with covid-19 referred to the Razi Medical Training Center in Rasht were examined in the form of continuous sampling in 1400–1401. The data collection tool is a 3-part questionnaire including 1) personal social and clinical information of a person infected with Covid-19, basic information from family members in contact with the infected person, and transfer to another person in the family 2) oral hygiene habits during quarantine 3) infection control behaviors. To analyze the collected data, independent t-tests, ANOVA, and Spearman's correlation were used for quantitative variables, and the Chi-square test was used for qualitative variables in SPSS software version 28, and the level of significance in all tests was 0.05. Results The findings showed that the rate of family transmission of the disease was 61.5%. There was no significant relationship between oral hygiene habits with the family transmission of Covid-19 (p = 0.108), but the use of a shared toothbrush container and a shared toothpaste tube among family members was significantly related to the rate of family transmission (p = 0.042 and p > 0.001, respectively) Conclusions There was no relationship between oral hygiene habits and the transmission of covid-19 disease in family members, but oral hygiene habits were effective in contracting a more severe form of the disease and the rate of hospitalization. The use of toothbrush containers and toothpaste tubes shared between family members increased the chance of family transmission of covid-19.

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Section: Discussionsupporting

confidence: 90%

Whether misuse the oral hygiene may facilitate the speared of Covid 19 among cohabiting individual?

Bashardoust

mahmoudzadeh

Khoshtarash

et al. 2022

Preprint

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“…Diabetes, hypertension, aging, immunodeficiency, and cardiovascular disease are among some of the risk factors for COVID-19 disease [ 4 ]. Furthermore, poor oral health, tooth loss, and periodontitis are regarded as common risk factors for adverse COVID-19 outcomes [ 5 ]. Some researchers have also indicated that excellent dental hygiene could help reduce the incidence of viral acute respiratory illness [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…A theoretical connection between poor dental status and COVID-19 severity and outcome was proposed in an observational analysis based on clinical oral examination and X-ray examination. This was because patients with poor dental health, such as caries and alveolar bone loss, had a higher rate of hospitalization [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets

Zhang

Sun²,

Xu³

et al. 2022

BMC Oral Health

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Background 2019 Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 pandemic has already had a serious influence on human existence, causing a huge public health concern for countries all around the world. Because SARS-CoV-2 infection can be spread by contact with the oral cavity, the link between oral illness and COVID-19 is gaining traction. Through bioinformatics approaches, we explored the possible molecular mechanisms linking the COVID-19 and periodontitis to provide the basis and direction for future research. Methods Transcriptomic data from blood samples of patients with COVID-19 and periodontitis was downloaded from the Gene Expression Omnibus database. The shared differentially expressed genes were identified. The analysis of Gene Ontology, Kyoto Encyclopedia of Genesand Genomes pathway, and protein–protein interaction network was conducted for the shared differentially expressed genes. Top 5 hub genes were selected through Maximal Clique Centrality algorithm. Then mRNA-miRNA network of the hub genes was established based on miRDB database, miRTarbase database and Targetscan database. The Least absolute shrinkage and selection operator regression analysis was used to discover possible biomarkers, which were then investigated in relation to immune-related genes. Results Fifty-six shared genes were identified through differential expression analysis in COVID-19 and periodontitis. The function of these genes was enriched in regulation of hormone secretion, regulation of secretion by cell. Myozenin 2 was identified through Least absolute shrinkage and selection operator regression Analysis, which was down-regulated in both COVID-19 and periodontitis. There was a positive correlation between Myozenin 2 and the biomarker of activated B cell, memory B cell, effector memory CD4 T cell, Type 17 helper cell, T follicular helper cell and Type 2 helper cell. Conclusion By bioinformatics analysis, Myozenin 2 is predicted to correlate to the pathogenesis and immune infiltrating of COVID-19 and periodontitis. However, more clinical and experimental researches are needed to validate the function of Myozenin 2.

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“…However, in the latter paper the association of periodontal breakdown with COVID-19 severity lost significance when corrected for age, sex, and BMI. In a post-mortem study, genetic material from SARS-CoV-2 was found present in the periodontium [ 14 ], and another pilot study presented a positive association of deleterious oral health-related conditions, especially periodontitis, and severe COVID-19 outcomes in hospitalized COVID-19 patients [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Operative Bleeding Complications in a Periodontitis Patient Testing Positive for COVID-19

et al. 2022

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Recent scientific evidence states that a subset of COVID-19 patients may have a risk of increased bleeding tendency. This case report presents a healthy 38-year-old woman with generalized stage III, grade C periodontitis with an abnormal post-operative blood clot formation who tested positive for COVID-19 after a standard periodontal surgery. Previously, two periodontal surgeries proceeded without any complications and were considered standard. On day one after the third periodontal surgery the patient had no complaints. On day two the patient reported excess bleeding in the oral cavity from the operated area simultaneously with fever and loss of taste. On day three the patient was seen in our clinic; general malaise symptoms and bleeding tendency had started to decline and the patient received a COVID-19 PCR test. At day four the test resulted positive, and she reported no further complaints of intraoral bleeding. Six months later the taste of the patient was still distorted. For this patient with free medical anamnesis, we suggest that the patient had increased plasma levels of tissue plasminogen activator during the crucial postoperative period due to an acute COVID-19 infection. This led to increased plasmin levels with a hyper-fibrinolytic state as a consequence.

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Poor oral health status and adverse COVID‐19 outcomes: A preliminary study in hospitalized patients

Cited by 31 publications

References 50 publications

Whether misuse the oral hygiene may facilitate the speared of Covid 19 among cohabiting individual?

Whether misuse the oral hygiene may facilitate the speared of Covid 19 among cohabiting individual?

Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets

Post-Operative Bleeding Complications in a Periodontitis Patient Testing Positive for COVID-19

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