Poor Outcome of Hormone Receptor–Positive Breast Cancer at Very Young Age Is Due to Tamoxifen Resistance: Nationwide Survival Data in Korea—A Report From the Korean Breast Cancer Society

Ahn, Sei Hyun; Son, Byung Ho; Kim, Seok Won; Kim, Kyung Sik; Lee, Jeong Eon; Ko, Sun-Hye; Han, Wonshik

doi:10.1200/jco.2006.10.3754

Cited by 228 publications

(209 citation statements)

References 25 publications

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“…An approximately similar high percentage of deaths was reported by van der Hage et al in their study group consisting of patients less than 40 years of age [27]. The Korean Breast Cancer Society reported that young age was associated with a greater probability of death in breast cancer patients [31]. Upon analysing tumour subtypes in the group of patients who died we found that of the 25 patients, the highest number of deaths was observed in the LumB subgroup, followed by the TNBC subgroup, LumA subgroup and HER2+ subgroup.…”

Section: Discussionsupporting

confidence: 76%

Retrospective Analysis of Clinicopathological Characteristics and Family History Data of Early-Onset Breast Cancer: A Single-Institutional Study of Hungarian Patients

Madaras

Baranyák²,

Kulka

et al. 2013

Pathol. Oncol. Res.

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Patients at young age (≤35 years) diagnosed with breast cancer (BC) are considered to have poor prognosis. The aim of the present study was to retrospectively analyse clinicopathological characteristics and prognosis in a group of young BC patients. We included women diagnosed with invasive breast carcinoma younger than/or at the age of 35 years. Between 1999 and 2009, 107 women with earlyonset BC were selected from the database of the 2nd Department of Pathology at Semmelweis University. For clinicopathological comparison, 55 women (36-45 years), 214 women (46-65 years), 110 women (66-75 years) and 58 women (76≤years) were also included in the analysis. Family history, clinicopathological and follow-up data were analysed. The tissue specimens were reviewed for histological type, nuclear grade, and estrogen receptor (ER), progesterone receptor (PgR), Ki67 and HER2 status (IHC4). The mean age in the study group was 31.6 years at the time of diagnosis. Histology showed a high incidence of grade III tumours in this group of patients (67.9 %), while only four cases (3.8 %) were considered grade I. According to the immunohistochemical results, 35.3 % of the study cases were considered as Luminal B (LumB: either being higly proliferative or co-expressing HER2) and 33.3 % as triple negative breast carcinomas (TNBC). The detailed questionnaire related to family history was completed and received in 49/107 cases (45.8 %). Analysis of these data revealed an affected family history of breast or ovarian carcinoma in first and second degree relatives in 51.0 %. A high proportion (52.0 %) of TNBC was observed among young women with a family history of the disease. Survival analysis of the 107 patients showed that 25 (23.3 %) women died until 31 December 2012. No significant difference in survival was detectable considering the regimen of systemic treatment (p=0.188). Regarding clinicopathological parameters, the immunophenotypes, grade, pT and pN values differred substantially between the age groups (p=0.001, for all), and the shortest relapse-free survival was seen among the youngest BC patients. This analysis illustrates that breast cancer arising in young women is characterized by the presence of less favorable subtypes such as LumB and TNBC. The increased proportion of TNBC was especially remarquable in the Lilla Madaras and Zsuzsanna Baranyák equal contribution. Oncol. Res. (2013) 19:723-729 DOI 10.1007 group of patients presenting with family history of the disease. The fact that a high rate of death occured and no significant difference in OS were notable regarding the scheme of systemic therapies (neoadjuvant vs. adjuvant) highlight the necessity of the development of new treatment strategies. Electronic supplementary material

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Section: Discussionsupporting

confidence: 76%

Retrospective Analysis of Clinicopathological Characteristics and Family History Data of Early-Onset Breast Cancer: A Single-Institutional Study of Hungarian Patients

Madaras

Baranyák²,

Kulka

et al. 2013

Pathol. Oncol. Res.

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“…In premenopausal women, this delay affects survival and, as a consequence, increases the potential years of life lost 40 . Some studies have shown that premenopausal women more frequently present with tumors of greater size, have a higher number of positive lymph nodes 41,42 , exhibit more aggressive tumors, and have worse prognoses when compared with postmenopausal women 39,43,44 . According to the suggestions of the World Health Organization (WHO) and the Breast Health Global Initiative (BHGI), developing countries should prioritize efforts to detect patients in earlier clinical stages by increasing awareness in women and access to treatment 45 .…”

Section: Diagnosis and Delay Concernsmentioning

confidence: 99%

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

Torres-Mejı́a

Navarro

Tuesca-Molina

et al. 2017

RIC

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Breast cancer is the most common malignant tumor among women of reproductive age and is also the most costly according to European reports. In this context, the aim of the present review is to identify factors that make breast cancer in premenopausal women an epidemiological challenge in developing countries. Epidemiological aspects of breast cancer, including risk factors, early detection methods, and treatment, are addressed. Breast cancer in premenopausal women should be included in the political and strategic agendas in developing countries to direct the necessary resources for prevention, detection, and control. (REV INVES CLIN. 2017;69:59-65)

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“…The incidence of breast cancer is still low in Korea, similar to most other Asian countries, while breast cancer is the most frequent cancer in women, and its incidence is increasing rapidly (2,3). The age distribution is also different than in western countries: the median age at diagnosis in Korean women is 45 years, ~15 years younger than American women; 9.5-12% of Korean breast cancers develop before the age of 35, which is much higher than in Western countries (4,5). In histologic subtype, lobular carcinoma is relatively rare in Korea.…”

Section: Introductionmentioning

confidence: 95%

Characterization of molecular subtypes of Korean breast cancer: An ethnically and clinically distinct population

Han

Nicolau

Noh³

et al. 2010

Int J Oncol

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Abstract. We aimed to investigate the molecular characteristics of Korean breast cancer. A cDNA microarray study (>42k clones) was performed on 69 breast cancers and three normal breast tissues. The subjects had a high percentage of HER-2 expression, hormone receptor negativity, and young onset. Molecular subtypes according to gene expression profiles were determined and their correlations to the clinicopathologic characteristics and patients outcome were analyzed. The tumors were subdivided into luminal-, normal breast-like, ERBB2+ , and basal-like subtypes according to the correlations to the previously described intrinsic genes and five centroids. Only a few tumors were highly correlated to the luminal B and normal-like centroids. The high grade tumors with high p53 and Ki-67 were found more commonly in non-luminal tumors. Distant recurrence-free survival was worse in ERBB2 + and basal-like subgroups than luminal tumors. In an unsupervised clustering with 864 genes, many interesting gene clusters were observed, some of which had not been previously described. Although the Korean breast cancers showed generally similar molecular phenotypes as Western studies, some distinct gene expression patterns and their association to clinical outcomes were observed.

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Poor Outcome of Hormone Receptor–Positive Breast Cancer at Very Young Age Is Due to Tamoxifen Resistance: Nationwide Survival Data in Korea—A Report From the Korean Breast Cancer Society

Cited by 228 publications

References 25 publications

Retrospective Analysis of Clinicopathological Characteristics and Family History Data of Early-Onset Breast Cancer: A Single-Institutional Study of Hungarian Patients

Retrospective Analysis of Clinicopathological Characteristics and Family History Data of Early-Onset Breast Cancer: A Single-Institutional Study of Hungarian Patients

The Epidemiological Challenges of Breast Cancer among Premenopausal Women in Limited Resource Settings

Characterization of molecular subtypes of Korean breast cancer: An ethnically and clinically distinct population

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