Poor ovarian response is associated with air pollutants: A multicentre study in China

Wu, Shanshan; Hao, Guimin; Zhang, Yunshan; Chen, Xiujuan; Ren, Haiqin; Fan, Yanli; Zhang, Yinfeng; Bi, Xiaoping; Du, Chenyu; Bai, Lina; Wu, Xueqing; Tan, Jichun

doi:10.1016/j.ebiom.2022.104084

Cited by 15 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study found that there was a negative correlation between exposure to O 3 and pregnancy rate [26]. Another study found that exposure to SO 2 increased risk of poor ovarian response, a common issue with IVF treatment [27 ▪ ]. A study by Jin et al [28] concluded that exposure to air pollutants at varying stages of IVF could significantly affect pregnancy outcomes, with the most obvious impacts being in patients aged less than 35 years, undergoing single embryo transfer and cleavage stage embryo transfer.…”

Section: Air Pollution and In-vitro Fertilization Outcomesmentioning

confidence: 74%

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Purpose of reviewRapid increase in world population accompanied by global industrialization has led to an increase in deployment of natural resources, resulting in growing levels of pollution. Here, we review recent literature on the impact of environmental pollution on human reproductive health and assisted reproduction outcomes, focusing on two of the most common: air pollution and endocrine disruptors. Recent findingsAir pollution has been associated with diminished ovarian reserve, uterine leiomyoma, decreased sperm concentration and motility. Air pollution also correlates with decreased pregnancy rates in patients undergoing infertility treatment using in-vitro fertilization (IVF). Similarly, Bisphenol A (BPA), a well studied endocrine disrupting chemical, with oestrogen-like activity, is associated with diminished ovarian reserve, and abnormal semen parameters, while clinical implications for patients undergoing infertility treatment remain to be established. SummaryThere is convincing evidence that environmental pollutants may have a negative impact on human health and reproductive potential. Air pollutions and endocrine disrupting chemicals found in water and food seem to affect male and female reproductive function. Large-scale studies are needed to determine the threshold values for health impact that may drive targeted policies.

show abstract

Section: Air Pollution and In-vitro Fertilization Outcomesmentioning

confidence: 74%

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Seli

Taylor

2023

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

“…Besides the age and ovarian reserve, numerous factors such as the consumption of high glycemic index foods [ 8 ], the presence of air pollution in the living area [ 14 ], and exposure to substances like benzene raise the risk of uIOR [ 15 ]. Despite studies showed higher concentrations of these substances in the follicle fluids of patients with unexpected poor ovarian response, it is not feasible to accurately assess the dietary habits or exposure to harmful substances and predict uIOR in women with normal ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters

Uncu,

Aslan,

Cakir

et al. 2024

J Ovarian Res

View full text Add to dashboard Cite

Background An unexpected impaired ovarian response pertains to an insufficient reaction to controlled ovarian hyperstimulation. This deficient reaction is identified by a reduced count of mature follicles and retrieved oocytes during an IVF cycle, potentially diminishing the likelihood of a successful pregnancy. This research seeks to examine whether the characteristics of antral follicles can serve as predictive indicators for the unexpected impaired ovarian response to controlled ovarian stimulation (COS). Methods This retrospective cohort study was conducted at a tertiary university hospital. The electronic database of the ART (assisted reproductive technologies) center was screened between the years 2012–2022. Infertile women under 35 years, with normal ovarian reserve [anti-Müllerian hormone (AMH) > 1.2 ng/ml, antral follicle count (AFC) > 5] who underwent their first controlled ovarian stimulation (COS) cycle were selected. Women with < 9 oocytes retrieved (group 1 of the Poseidon classification) constituted the group A, whereas those with ≥ 9 oocytes severed as control (normo-responders) one (group B). Demographic, anthropometric and hormonal variables together with COS parameters of the two groups were compared. Results The number of patients with < 9 oocytes (group A) was 404, and those with ≥ 9 oocytes were 602 (group B). The mean age of the group A was significantly higher (30.1 + 2.9 vs. 29.4 + 2.9, p = 0.01). Group A displayed lower AMH and AFC [with interquartile ranges (IQR); AMH 1.6 ng/ml (1-2.6) vs. 3.5 ng/ml (2.2–5.4) p < 0.01, AFC 8 (6–12) vs. 12 (9–17), p < 0.01]. The number of small antral follicles (2–5 mm) of the group A was significantly lower [6 (4–8) vs. 8 (6–12) p < 0.01), while the larger follicles (5–10 mm) remained similar [3 (1–5) vs. 3(1–6) p = 0.3] between the groups. Conclusion The propensity of low ovarian reserve and higher age are the main risk factors for the impaired ovarian response. The proportion of the small antral follicles may be a predictive factor for ovarian response to prevent unexpected poor results.

show abstract

“…The ovarian response to exogenous Gn varies by population and cycle, with some populations responding poorly, resulting in low live birth rates and high cycle cancellation rates [3]. Poor ovarian response (POR) is a condition in which fewer than four follicles and/or oocytes are developed/obtained following ovarian stimulation with the intention of obtaining more follicles and oocytes [4]. The incidence of POR has been estimated to range between 9-24% [5].…”

Section: Introductionmentioning

confidence: 99%

Increased starting doses of exogenous gonadotropins do not improve IVF-ET outcomes in expected poor ovarian responders

et al. 2023

Preprint

View full text Add to dashboard Cite

Background To evaluate whether increasing the starting dose of exogenous gonadotropins (Gn) improves in vitro fertilization and embryo transfer (IVF-ET) outcomes in patients with the expected poor ovarian response (POR), as defined by antral follicles count (AFC) ≤ 9. The outcomes of IVF-ET in patients with expected POR between January 2016 and December 2021 were compared retrospectively. A total of 2448 IVF cycles were studied, including 709 with a starting Gn dose of 150 IU (Group A), 1006 with 225 or 300 IU (Group B), and 733 with 375 or 450 IU (Group C). The cumulative live birth rate was the primary outcome, with secondary outcomes including the number of oocytes retrieved, the number of normal fertilization, the number of transferable embryos, positive pregnancy, clinical pregnancy, pregnancy loss, ectopic pregnancy of fresh embryo transfer, and cycle cancellation rate. Multivariate logistic regression analysis was used to control the confounding factors.Results The cumulative live birth rates (28.2% in group A vs. 23.6% in group B vs. 17.9% in group C, P < 0.001) were statistically significant. The relationship between cumulative live birth rate and grouping was investigated using multivariate logistic regression. The odds ratio (OR) of group B versus group A was 0.887, 95% confidence interval (CI) 0.655–1.174, P = 0.378, and the OR of group C versus group A was 0.77, 95% CI 0.545–1.089, P = 0.139. The total number of retrieved oocytes was 4.49 ± 3 in group A, 4.53 ± 2.8 in group B, and 3.91 ± 2.6 in group C. P < 0.001 indicated that the differences were statistically significant. Multivariate logistic regression was used to investigate the relationship between the number of retrieved oocytes and grouping. The OR of group B versus group A was 0.993, 95% CI 0.713–1.383, P = 0.966, and the OR of group C with group A was 0.881, 95% CI 0.614–1.264, P = 0.492.Conclusions Increasing the starting dose of Gn did not increase the number of oocytes retrieved or the cumulative live birth rate in POR patients.

show abstract

Poor ovarian response is associated with air pollutants: A multicentre study in China

Cited by 15 publications

References 47 publications

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction

Do we overlook predictive factors in Poseidon 1 patients? A retrospective analysis co-evaluating antral follicle counts & diameters

Increased starting doses of exogenous gonadotropins do not improve IVF-ET outcomes in expected poor ovarian responders

Contact Info

Product

Resources

About