Poor periodontal health: A cancer risk?

Rajesh, K S; Thomas, Deepak; Hegde, Shashikanth; Kumar, Manoj

doi:10.4103/0972-124x.124470

Cited by 15 publications

(7 citation statements)

References 22 publications

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“…On the other hand, cancer patients were less likely to develop Alzheimer's disease [ 73 ]. Furthermore, the periodontal pockets were reported to be reservoirs for several viruses, including HPV [ 74 ], thus suggesting the probable association of cervical cancer development and periodontitis, which is a chronic oral infection caused by the synergistic action of some bacteria and viruses. In addition to these diseases, disease pathways for colorectal, bladder, breast, lung, stomach, and prostate cancers were also significantly enriched with the core genes of cervical cancer (p-value < 10 −3 ).…”

Section: Discussionmentioning

confidence: 99%

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

2018

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The malignant neoplasm of the cervix, cervical cancer, has effects on the reproductive tract. Although infection with oncogenic human papillomavirus is essential for cervical cancer development, it alone is insufficient to explain the development of cervical cancer. Therefore, other risk factors such as host genetic factors should be identified, and their importance in cervical cancer induction should be determined. Although gene expression profiling studies in the last decade have made significant molecular findings about cervical cancer, adequate screening and effective treatment strategies have yet to be achieved. In the current study, meta-analysis was performed on cervical cancer-associated transcriptome data and reporter biomolecules were identified at RNA (mRNA, miRNA), protein (receptor, transcription factor, etc.), and metabolite levels by the integration of gene expression profiles with genome-scale biomolecular networks. This approach revealed already-known biomarkers, tumor suppressors and oncogenes in cervical cancer as well as various receptors (e.g. ephrin receptors EPHA4, EPHA5, and EPHB2; endothelin receptors EDNRA and EDNRB; nuclear receptors NCOA3, NR2C1, and NR2C2), miRNAs (e.g., miR-192-5p, miR-193b-3p, and miR-215-5p), transcription factors (particularly E2F4, ETS1, and CUTL1), other proteins (e.g., KAT2B, PARP1, CDK1, GSK3B, WNK1, and CRYAB), and metabolites (particularly, arachidonic acids) as novel biomarker candidates and potential therapeutic targets. The differential expression profiles of all reporter biomolecules were cross-validated in independent RNA-Seq and miRNA-Seq datasets, and the prognostic power of several reporter biomolecules, including KAT2B, PCNA, CD86, miR-192-5p and miR-215-5p was also demonstrated. In this study, we reported valuable data for further experimental and clinical efforts, because the proposed biomolecules have significant potential as systems biomarkers for screening or therapeutic purposes in cervical carcinoma.

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Section: Discussionmentioning

confidence: 99%

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

2018

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“…Further, periodontal disease is a very common problem among the elderly, being linked to 46% of American adults between the years of 2007 and 2012. [17] This disease of the tissues that hold the teeth in place can create systemic medical conditions such as aspiration pneumonia [18] [20], and results in many ramifications, ranging from a depressed mental state to renal disease. [21] Of even greater interest due to its relevance in more recent times, perhaps, is the fact that a 2020 study out of the University of Toronto has stated that there is evidence showing that patients with periodontal disease may be much more likely to have heightened issues with COVID-19.…”

Section: Why Oral Care Is Vitally Important In the Terminal And Depenmentioning

confidence: 99%

Why Are We Missing the Teeth? Addressing Oral Care Neglect in the Palliative Patient

Soileau¹

2021

Suggestions for Addressing Clinical and Non-Clinical Issues in Palliative Care

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Palliative care is meant to comfort and console the mind, body, and spirit of the individual nearing the end of life to improve the quality of one’s existence. It focuses on those with symptoms and stressors secondary to serious illnesses such as in cancer, pneumonia, Parkinson’s disease, Alzheimer’s, hypertension, diabetes, and microbial diseases. For several reasons, however, oral care and the consequences thereof in most cases go without notice for these patients. Further, the dentist is rarely, if ever, listed as necessary staff in hospice care programs. Because terminal patients’ symptoms can include depression, pain, anxiety, loss of appetite, nausea, fatigue, among other issues, all related to speaking, chewing, and deglutition, this chapter will discuss why care of the mouth and dentition is typically lacking both in at-home and institutional environments, why such care is necessary, and best to meet the oral needs of patients in the later stages of life.

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“…Incidence of aspiration pneumonia is decreased, 15 and heart disease, diabetes, and cancer can be linked to gum disease from neglect of oral monitoring and maintenance. 16 Periodontal disease results in discomfort secondary to the release of inflammatory cytokines, growth factors, prostaglandins, and enzymes 17 and can increase depression and chronic kidney disease. 18 These are just a few systemic ramifications of periodontal disease.…”

Section: Oral Care and Quality Of Lifementioning

confidence: 99%

The Hospice Patient’s Right to Oral Care

Soileau

Elster

2018

J Palliat Care

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The hospice philosophy embraces palliative care for the terminally ill, for whom quality of life is the central focus of comfort care management. Often, caregivers hesitate or simply do not elect to extend oral care for patients nearing the end of life, due to difficulties encountered in patient compliance, a sense of futility in doing so, staff time constraints in prioritizing care, underfunding, or a lack of education as to how and why such care should be delivered to the hospice patient. This article aims to show physiological and psychosocial reasons why the hospice patient has a need for properly and regularly implemented oral care and why dental professionals have an ethical responsibility to address the current void that exists in hospice-centered oral care. Varying viewpoints are discussed regarding the need for oral health monitoring and maintenance in both the capable patient with capacity and in the patient who lacks capacity and is totally dependent, yet who exhibits no particular signs of oral distress nor desire for hygiene measures. Consideration is given to family dynamics in such care. Oral care of the elderly patients and terminally ill is sorely lacking, and dental educators are challenged to cultivate in students a sense of professional duty toward caring for the vulnerable elderly patients. Dental professionals should create initiatives in developing, promoting, and implementing an appropriate standard of oral care for the hospice patient.

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Poor periodontal health: A cancer risk?

Cited by 15 publications

References 22 publications

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

Why Are We Missing the Teeth? Addressing Oral Care Neglect in the Palliative Patient

The Hospice Patient’s Right to Oral Care

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