Poor Prognosis Associated With Thrombocytosis in Patients With Renal Cell Carcinoma

Symbas, Nikolas P.; Townsend, Murphy F.; El-Galley, Rizk; Keane, Thomas E.; Petros, John A.

doi:10.1097/00005392-199904010-00783

Cited by 38 publications

(60 citation statements)

References 13 publications

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“…Platelets play an important role in angiogenesis and proteolysis of the basal membrane, and both situations are present in the process of tumor growth and metastatic spread [7]. Some studies have found that thrombocytosis is associated with poor survival in renal [8][9][10][11][12][13], gynecologic [14][15][16][17][18][19][20][21], and lung tumors [22,23]. Thrombocytosis has also been evaluated in pancreatic carcinoma, but the number of patients studied is small and the results are conflicting [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma

et al. 2008

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“…A total of 20 studies (7,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) that met the inclusion criteria were retrieved for analysis in the present study. The selection process of the included studies is presented in Fig.…”

Section: Identification Of Eligible Studiesmentioning

confidence: 99%

The clinicopathological and prognostic role of thrombocytosis in patients with cancer: A meta-analysis

Zhang

et al. 2017

Oncology Letters

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Abstract. Previous studies have linked the presence of thrombocytosis with the progression and development of cancer; however, this trend requires further investigation. The present study aimed to derive an estimation of the degree of association between thrombocytosis and the 5-year overall survival rate of patients with cancer, as well as common clinicopathological features, by performing a meta-analysis of 20 (n=12,778) published studies. The PubMed and Embase databases were searched systematically for all relevant articles published in English. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using a fixed effects or random effects model to evaluate the degree of the observed associations. The results suggested that thrombocytosis (platelet count, >400x10 9 /l) correlated with a decreased 5-year overall survival rate (OR=2.70, 95% CI=2.03-3.61) and an advanced tumor-node-metastasis stage (III + IV; OR=2.14, 95% CI=1.58-2.90). Furthermore, these associations remained robust following stratification of the data by cancer type and ethnicity. In addition, thrombocytosis (platelet count, >300x10 9 /l) correlated with a decreased 5-year overall survival rate in patients with colorectal cancer (OR=3.49, 95% CI=1. 44-8.46). Although certain biases were not able to be eliminated, the present meta-analysis suggested that thrombocytosis is a valuable indicator for the evaluation of pathological diagnosis and prognosis for patients with cancer. Further studies are required to investigate the effect of thrombocytosis on the prognosis of patients with cancer. IntroductionDespite improvements in early diagnosis, radical surgery and various novel treatments, the prognosis for patients with cancer remains poor (1). Esophageal cancer patients without detectable metastasis in the clinic at the time of diagnosis may still succumb to cancer recurrence following surgery (2). This suggests that certain metastasis of cancer may not be detected using conventional biochemistry testing, imaging or histopathological methods (2). Therefore, a novel biological marker that may enhance the ability to accurately predict patient treatment outcomes is required. In previous years, a number of studies have investigated potential prognostic factors in patients with cancer. Previous studies have demonstrated that certain preoperative alterations in hematological parameters may be associated with patient outcomes for several forms of solid tumors (3). In addition, it has been suggested that circulating platelet (PLT)-tumor cell aggregates may promote cancer metastasis (4).Previous studies have investigated the association between thrombocytosis and tumor growth and development in various forms of malignancy (5-7); however, this trend requires further investigation. Yu et al (8) demonstrated, using a meta-analysis, that thrombocytosis (PLT count >400x10 9 /l) may be associated with a poorer prognosis for patients with a gynecological malignancy. Therefore, the present meta-analysis was performed in order to assess the associati...

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“…2,3,4,5 Surgery is the preferred treatment for these malignancies. However, even after great progress in chemotherapy, radiotherapy and targeted therapy, prognosis of head and neck squamous cell carcinoma is poor owing to aggressive local invasion and metastasis leading to recurrence.…”

Section: Introductionmentioning

confidence: 99%

Role of Platelet Counts in Prognostication of Head And Neck Squamous Cell Carcinoma.

Khatib¹,

Shukla²,

Kanetkar³

et al. 2016

IOSR

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Poor Prognosis Associated With Thrombocytosis in Patients With Renal Cell Carcinoma

Cited by 38 publications

References 13 publications

Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma

Preoperative Platelet Count and Survival Prognosis in Resected Pancreatic Ductal Adenocarcinoma

The clinicopathological and prognostic role of thrombocytosis in patients with cancer: A meta-analysis

Role of Platelet Counts in Prognostication of Head And Neck Squamous Cell Carcinoma.

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