Daily measurements of sulfur dioxide (SO2) emissions from active volcanoes in Ecuador and southern Colombia between September 2004 and September 2006, derived from the Ozone MonitoringInstrument (OMI) on NASA's EOS/Aura satellite, are presented. OMI is an ultraviolet/visible spectrometer with an unprecedented combination of spatial and spectral resolution, and global coverage, that permit daily measurements of passive volcanic degassing from space. We use non-interactive processing methods to automatically extract daily SO2 burdens and information on SO2 sources from the OMI datastream. Maps of monthly average SO2 vertical columns retrieved by OMI over Ecuador and S. Colombia are also used to illustrate variations in regional SO2 loading and to pinpoint sources. The dense concentration of active volcanoes in Ecuador provides a stringent test of OMI's ability to distinguish SO2 from multiple emitting sources. Our analysis reveals that Tungurahua, Reventador and Galeras were responsible for the bulk of the SO2 emissions in the region in the timeframe of our study, with no significant SO2 discharge detected from Sangay. At Galeras and Reventador, we conclude that OMI can detect variations in SO2 release related to cycles of conduit sealing and degassing, which are a critical factor in hazard assessment. The OMI SO2 data for Reventador are the most extensive sequence of degassing measurements yet available for this remote volcano, which dominated regional SO2 production in June -August 2005. At Tungurahua, the OMI measurements span the waning stage of one eruptive cycle and the beginning of another. We observe a good qualitative agreement between OMI-derived SO2 burdens and coincident ground-based SO2 flux measurements at Tungurahua, and note increasing SO2 emissions in the months prior to large explosive eruptions of the volcano in July and August 2006. Cumulative SO2 loadings measured by OMI yield a total of ~1.16 Tg SO2 emitted by volcanoes on mainland Ecuador/S. Colombia between September 2004 and September 2006; as much as 95% of this SO2 may originate from non-eruptive degassing. Approximate apportionment of the total SO2 loading indicates that ~40% originated from Tungurahua, with ~30% supplied by both Reventador and Galeras. Inclusion of SO2 production by eruptions of Fernandina and Sierra Negra (Galápagos Islands) in May and October 2005, respectively, yields a total SO2 release of ~3.24 Tg in this period. These measurements of volcanic SO2 degassing in Ecuador confirm OMI's potential as an effective, economical and risk-free tool for daily monitoring of SO2 emissions from hazardous volcanoes. Abstract Daily measurements of sulfur dioxide (SO 2 ) emissions from active volcanoes in Ecuador and southern Colombia between September 2004 and September 2006, derived from the OzoneMonitoring Instrument (OMI) on NASA's EOS/Aura satellite, are presented. OMI is an ultraviolet/visible spectrometer with an unprecedented combination of spatial and spectral resolution, and global coverage, that permit daily measurements ...