Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population

Tanno, Kozo; Ohsawa, Masaki; Onoda, Toshiyuki; Itai, Kazuyoshi; Sakata, Kiyomi; Tanaka, Fumitaka; Makita, Shinji; Nakamura, Motoyuki; Omama, Shinichi; Ogasawara, Kuniaki; Ishibashi, Yutaka; Kuribayashi, Toru; Koyama, Tomiko; Okayama, Akira

doi:10.1016/j.jpsychores.2012.05.013

Cited by 35 publications

(55 citation statements)

References 44 publications

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“…We should also note, however, that our sex-differentiated findings were inconsistent with some studies from middle and older adulthood that reported that SRH-inflammatory marker associations were present in females even after accounting for health-related adiposity (Janszky et al, 2005; Unden et al, 2007), or that these association were stronger in females than in males (Lekander et al, 2004; Tanno et al, 2012). Jylhä (2009) proposed that sex differences in associations between SRH and its correlates and outcomes could change with age.…”

Section: Bmi and Sex Differentiated Srh-crp Associations In Young Adultscontrasting

confidence: 99%

“…Subjective perceptions of the body’s functioning—including SRH—are associated with inflammatory markers even after adjusting for health behaviors, chronic disease risk indicators and/or measures of actual chronic or other illness in samples of mostly middle and older adults (e.g., Christian et al, 2011; Cohen et al, 1997; Jylhä et al, 2006; Lekander et al, 2004; Tanno et al, 2012; Unden et al, 2007). Although many young adults have not yet been diagnosed with chronic illness, almost half of the young adults in the nationally representative sample studied here rated their health as less than “very good,” and we tested whether SRH is associated with elevated hs-CRP during young adulthood and whether these linkages differ by sex.…”

Section: Discussionmentioning

confidence: 99%

“…Recent research from mostly middle and older adulthood has highlighted pro-inflammatory cytokines and their products, including the acute phase reactant C-reactive protein as key biological intermediaries in the link between SRH and morbidity and mortality (e.g., Christian et al, 2011; Cohen et al, 1997; Janszky et al, 2005; Jylhä et al, 2006; Lekander et al, 2004; Tanno et al, 2012; Unden et al, 2007). For example, in a study of generally healthy subjects in middle and older adulthood, those with the highest levels of Interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) also reported the poorest SRH (Christian et al, 2011).…”

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confidence: 99%

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Self-rated health and C-reactive protein in young adults

Shanahan¹,

Bauldry²,

Freeman³

et al. 2014

Brain, Behavior, and Immunity

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Background Poor self-rated health (SRH) and elevated inflammation and morbidity and mortality are robustly associated in middle- and older-aged adults. Less is known about SRH-elevated inflammation associations during young adulthood and whether these linkages differ by sex. Methods Data came from the National Longitudinal Study of Adolescent Health. At Wave IV, young adults aged 24–34 reported their SRH, acute and chronic illnesses, and sociodemographic and psychological characteristics relevant to health. Trained fieldworkers assessed medication use, BMI, waist circumference, and also collected bloodspots from which high-sensitivity CRP (hs-CRP) was assayed. The sample size for the present analyses was N=13,236. Results Descriptive and bivariate analyses revealed a graded association between SRH and hs-CRP: Lower ratings of SRH were associated with a higher proportion of participants with hs-CRP > 3 mg/L and higher mean levels of hs-CRP. Associations between SRH and hs-CRP remained significant when acute and chronic illnesses, medication use, and health behaviors were taken into account. When BMI was taken into account, the association between SRH and hs-CRP association fully attenuated in females; a small, but significant association between SRH and hs-CRP remained in males. Conclusion Poor SRH and elevated hs-CRP are associated in young adults, adjusting for other health status measures, medication use, and health behavior. In males, SRH provided information about elevated hs-CRP that was independent of BMI. In females, BMI may be a better surrogate indicator of global health and pro-inflammatory influences compared to SRH.

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Section: Bmi and Sex Differentiated Srh-crp Associations In Young Adultscontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Self-rated health and C-reactive protein in young adults

Shanahan¹,

Bauldry²,

Freeman³

et al. 2014

Brain, Behavior, and Immunity

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“…C-reactive protein levels prospectively predict a number of adverse outcomes such as cardiovascular disease (Danesh et al, 2004) and diabetes (Pradhan, Manson, Rifai, Buring, & Ridker, 2001), as well as consequent mortality (Kuller, Tracy, Shaten, & Meilahn, 1996;Wang et al, 2006). They correlate with self-rated health in women (Tanno et al, 2012). C-reactive protein levels also tend to increase with age (Hutchinson et al, 2000), making them in effect a marker of age-related increase in morbidity and tissue damage.…”

Section: -Tracy Chapman Fast Carmentioning

confidence: 99%

What the future held: Childhood psychosocial adversity is associated with health deterioration through adulthood in a cohort of British women

Nettle

2014

Preprint

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Childhood psychosocial adversity is associated with accelerated onset of reproductive effort in women. Adaptive explanations for this phenomenon are built on the assumption that greater childhood psychosocial adversity is statistically associated with having a shorter period of healthy adult life during which reproduction will be possible. However, this critical assumption is never actually tested using individual-level longitudinal data. In this study, we revisit a large, longitudinally studied cohort of British women. In an earlier study, we showed that a simple index of psychosocial adversity in the first seven years of life predicted age at first pregnancy in a dose-dependent manner. Here, we show that the same index of adversity predicts accelerated deterioration of health across the potentially reproductive period, and increased levels of the inflammatory biomarker c-reactive protein at age 44. These associations are robust to controlling for adult socioeconomic position, and do not appear to be a consequence of accelerated reproductive strategy, smoking, or BMI. We argue that childhood psychosocial adversity may lead to the lasting embedding of somatic damage that accelerates age-related physical decline. This provides a compelling adaptive rationale for the accelerated reproductive schedules observed in women who experience childhood psychosocial adversity.

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“…Interpreted as a spontaneous subjective assessment of a person's health status, SRH is regarded as the most precise measure of actual experienced health. Public health surveys from different countries and social contexts have documented a relationship between SRH and genetic factors, inflammation and allostatic load, indicating a connection between SRH and biological processes.…”

Section: Introductionmentioning

confidence: 99%

Assessment of self‐rated health 5 years after Roux‐en‐Y gastric bypass for severe obesity

et al. 2019

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Background Patients' perceptions of health change after bariatric surgery are complex. The aim of this study was to explore whether self‐rated health (SRH), a widely used tool in public health research, might be relevant as an outcome measure after Roux‐en‐Y gastric bypass (RYGB) for severe obesity. Methods This was a single‐centre retrospective study of a local quality registry. SRH score was registered at baseline and 5 years after RYGB. SRH, one of the 36 items in the quality‐of‐life Short Form 36 (SF‐36®) questionnaire, is the answer to this single question: ‘In general, would you say your health is excellent (1), very good (2), good (3), fair (4) or poor (5)?’ Change in SRH was analysed in relation to change in weight, co‐morbidities and quality of life after 5 years. Results Of a total of 359 patients who underwent RYGB between September 2006 and February 2011, 233 (64·9 per cent) reported on SRH before and 5 years after surgery. Of these, 180 (77·3 per cent) were women, and the mean(s.d.) age was 40(9) years. Some 154 patients (66·1 per cent) reported an improvement in SRH, 60 (25·8 per cent) had no change, and SRH decreased in 19 patients (8·2 per cent). SRH in improvers was related to better scores in all SF‐36® domains, whereas SRH in non‐improvers was related to unchanged or worsened scores in all SF‐36® domains except physical function. Conclusion Two‐thirds of patients reported improved SRH 5 years after RYGB for severe obesity. In view of its simplicity, SRH may be an easy‐to‐use outcome measure in bariatric surgery.

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Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population

Cited by 35 publications

References 44 publications

Self-rated health and C-reactive protein in young adults

Self-rated health and C-reactive protein in young adults

What the future held: Childhood psychosocial adversity is associated with health deterioration through adulthood in a cohort of British women

Assessment of self‐rated health 5 years after Roux‐en‐Y gastric bypass for severe obesity

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