Poor sleep quality is negatively associated with low cognitive performance in general population independent of self-reported sleep disordered breathing

Abstract

Background Sleep disordered breathing (SDB) plays a significant role in both sleep quality and cognition and whether it has an impact on the relationship between above two factors remains to be clear. The study aimed to explore the association between sleep quality and cognitive performance in general population by considering influence of sleep disordered breathing (SDB). Methods In this cross-sectional study, we enrolled subjects aged ≥ 18 years using a multi-stage random sampling method. Cognitive status was assessed using Mini Mental State Examination (MMSE) questionnaire, sleep quality using Pittsburgh Sleep Quality Index (PSQI) and SDB was assessed using No-SAS scale, respectively. Multi-variable logistic regression was applied to examine the association of sleep quality and cognitive performance. Subgroup analyses were performed in different age groups, and in those with and without SDB. Results Finally, 30,872 participants aged 47.5 ± 13.8 years with 53.5% women were enrolled, of whom 32.4% had poor sleep quality and 18.6% had low cognitive performance. Compared with good sleepers, subjects with poor sleep quality exhibited significantly higher presence of low cognitive performance (23.7% vs 16.2%, P < 0.001). Poor sleepers revealed 1.26 (95%CI: 1.16,1.36), 1.26 (1.08,1.46) and 1.25 (1.14,1.37) fold odds for low cognitive performance in general population and in subjects with and without self-reported SDB respectively. Stratified by age and SDB, the association was observed in young and middle-aged group without SDB (OR = 1.44, 95%CI: 1.30,1.59) and in the elderly group with SDB (OR = 1.30, 95%CI: 1.07,1.58). Conclusions Sleep quality is in a negative association with cognitive performance in general population independent of SDB, implying improvement of sleep disturbances is a potential objective of intervention strategies for cognitive protection at population level.

Association of objective and subjective parameters of obstructive sleep apnea with plasma aldosterone concentration in 2,066 hypertensive and 25,368 general population

“…In addition, a positive independent linear association between log No-SAS score and log PAC was observed, consistent in age-stratified analysis. Previous relevant studies were conducted mainly in resistant hypertension, in which PA accounts for as high as 36% ( 25 ) and as high as 22.0% of general hypertension ( 26 , 27 ). These results are consistent with those of our clinical data and with those of previous studies ( 18 – 20 , 24 ).…”

“…As in flow chart ( Figure 1B ), in general population, we used a multi-stage stratified sampling method to enroll study participants aged ≥15 years from Emin county Xinjiang, as described in our previous studies ( 26 – 28 ). For the current study, we excluded participants with hypertension under any antihypertensive agent treatment at the time of survey.…”

The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study

“…Alcohol use was defined as consuming at least one glass of alcohol in the past month ( 24 ). Physical activity was determined by yes/no responses to the question, “do you engage in physical activity at least 30 minutes at work and/or during leisure time more than four days a week” ( 25 ). Sleep duration was identified by two questions, “how early do you usually go to sleep at night and how early do you usually wake up” ( 26 ).…”

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

“…It is interesting to note that even one night of sleep deprivation causes an increase in the level of beta-amyloid (Aβ) protein in the brain of young and healthy volunteers [ 3 , 4 ]. There is a growing body of evidence suggesting that sleep disturbance is an independent risk factor of cognitive impairment, and the measurement of sleep quality can be an innovative method to screen for Alzheimer’s disease (AD) [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. It is well known that people with AD experience poor and short sleep, which is associated with increased Aβ deposition in their brains [ 8 , 11 ].…”