Poorer clinical outcomes of early‐onset peritonitis in elderly peritoneal dialysis patients: A longitudinal and multicenter study

Abstract

Introduction: Early-onset peritonitis (EOP) is a risk factor for mortality in peritoneal dialysis (PD) patients. This study investigates the clinical features and outcomes of EOP in elderly patients. Methods: This multicenter retrospective study evaluated 433 elderly PD patients with end-stage renal disease. The cohort was divided into nonperitonitis group (n = 239), EOP group (≤12 months, n = 109) and late-onset peritonitis (LOP) group (>12 months, n = 85). Clinical data, treatment results, and outcomes were compared between the groups.Results: Compared with LOP group, there were no significant intergroup differences in the rate of primary recovery, complete cure, relapse, catheter removal, or death from PDAP (p >0.05) in the most recent PDAP episode. However, Kaplan-Meier analysis showed that patients in the EOP group were likely to have multiple episodes of PD-associated peritonitis (PDAP), technique failure, all-cause death, and composite endpoint in the long-term prognostic outcomes (p <0.001).Conclusions: EOP is significantly associated with poorer clinical outcomes in older PD patients. K E Y W O R D Searly-onset peritonitis, elderly peritoneal dialysis patients, outcomes, peritoneal dialysisassociated peritonitis

Safety of a 24‐h‐or‐less break‐in period in elderly patients undergoing urgent‐start peritoneal dialysis: A multicenter retrospective cohort study

“…Previous studies of adult patients of all ages undergoing USPD had similar findings [27][28][29]. Our previous study indicated that patients' unskilled PD technique could increase the risk of early-onset peritonitis in elderly patients during the early stage of dialysis [37]. Phang et al [32] suggested that dialysate leakage may increase the risk of peritonitis.…”

Ten-Year Single-Center Study Examining Patient Survival after Commencing Long-Term Peritoneal Dialysis

“…While prior literature has suggested a potential reduction in peritonitis risk in APD patients, our research uncovered a statistically significant difference, with 56.0% of cases occurring in APD compared to 44.0% in CAPD (p < 0.001). The observed variation prompts further inquiry into factors that may contribute to these differences, including patient demographics, adherence to aseptic techniques, and the potential impact of the automated nature of APD [28,29]. Understanding and addressing these nuances in peritonitis risk across peritoneal dialysis modalities is crucial for optimizing patient care and outcomes in the long-term management of end-stage renal disease.…”