Poorer sleep impairs brain health at midlife

Namsrai, Tergel; Ambikairajah, Ananthan

doi:10.1038/s41598-023-27913-9

Cited by 10 publications

(4 citation statements)

References 66 publications

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“…Additionally, (ii) we addressed possible collinearity effects underlying the original analysis by implementing separate linear models for each SH variable. With respect to previous findings of age- and sex-dependent associations between sleep and brain imaging variables in the UK Biobank, 43 we also implemented exploratory linear models comprising interaction effects between age or sex and sleep-related variables (iii).…”

Section: Methodsmentioning

confidence: 99%

Associations between sleep health and grey matter volume in the UK Biobank cohort (n= 33 356)

Schiel

Tamm

Holub

et al. 2023

Brain Communications

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As suggested by previous research, sleep health is assumed to be a key determinant of future morbidity and mortality. In line with this, recent studies have found that poor sleep is associated with impaired cognitive function. However, to date, little is known about brain structural abnormalities underlying this association. Although recent findings link sleep health deficits to specific alterations in grey matter volume, evidence remains inconsistent and reliant on small sample sizes. Addressing this problem, the current preregistered study investigated associations between sleep health and grey matter volume (139 imaging-derived phenotypes) in the UK Biobank cohort (33,356 participants). Drawing on a large sample size and consistent data acquisition, sleep duration, insomnia symptoms, daytime sleepiness, chronotype, sleep medication, and sleep apnoea were examined. Our main analyses revealed that long sleep duration was systematically associated with larger grey matter volume of basal ganglia substructures. Insomnia symptoms, sleep medication and sleep apnoea were not associated with any of the 139 imaging-derived phenotypes. Short sleep duration, daytime sleepiness as well as late and early chronotype were associated with solitary imaging-derived phenotypes (no recognizable pattern, small effect sizes). To our knowledge, this is the largest study to test associations between sleep health and grey matter volume. Clinical implications of the association between long sleep duration and larger grey matter volume of basal ganglia are discussed. Insomnia symptoms as operationalised in the UK Biobank do not translate into grey matter volume findings.

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Section: Methodsmentioning

confidence: 99%

Associations between sleep health and grey matter volume in the UK Biobank cohort (n= 33 356)

Schiel

Tamm

Holub

et al. 2023

Brain Communications

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“…Although links between short sleep and health have been more extensively studied than long sleep, studies indicate that long sleep is more prevalent worldwide (Bin et al, 2013), and meta-analytic studies have also linked long sleep with metabolic syndrome, diabetes, and stroke, but not hypertension (Jike et al, 2018). Short sleep has been linked to oxidative stress, changes in metabolic processes, depression, and inflammation, which may link it to long-term health outcomes (Namsrai et al, 2023). Long sleep may be related to health outcomes because of several mechanisms including depression, fatigue, underlying disease, and sedentary behaviors (Grandner & Drummond, 2007).…”

Section: Childhood Adversity Reactivity and Sleep In Adulthoodmentioning

confidence: 99%

Relationships between sleep duration and health among U.S. adults with a history of household incarceration during childhood.

Jelsma,

Varner,

Benner

2024

American Journal of Orthopsychiatry

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The rate of incarceration in the United States has increased at an alarming rate in the past 30 years and thus so has the number of children having a household member incarcerated (referred to as household incarceration). Associations between experiencing household incarceration in childhood and later negative health and developmental outcomes are well-documented; however, the underlying mechanisms linking this childhood stressor and adult outcomes have been less well studied. Using state Behavioral Risk Factor Surveillance System survey data (N = 145,102), this study examines how experiencing household incarceration during childhood is associated with mental and physical health in adulthood and mediational pathways through suboptimal sleep (short or long sleep). Results indicate there were significant indirect effects of household incarceration to physical and mental distress through short sleep (≤6 hr per 24 hr) and long sleep (≥10 hr per 24 hr), and a significant indirect effect of household incarceration to body mass index through short sleep. Findings from the present study highlight indirect pathways through which household incarceration in childhood is linked with sleep health in adulthood and, in turn, to negative mental and physical health.

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“…This should include societal and political changes aiming at increasing physical activity, social integration, education and lifelong learning, cognitive activity, adopting a healthy diet, stopping smoking and reducing alcohol intake, and-with respect to elderly people-reducing the burden of chronic conditions and anticholinergic medications [62]. In middle-aged individuals, poor sleep may be an additional factor to target, as this is associated with lower brain health [63]. It is imperative that these changes are implemented at a global level, thus making brain health a worldwide priority with strategic and substantial investments [64].…”

Section: Beyond High-risk: Universal Preventive Approach In Mid-and L...mentioning

confidence: 99%

Brain Health and Cognition in Older Adults: Roadmap and Milestones towards the Implementation of Preventive Strategies

Pozzi,

Remoli,

Tremolizzo

et al. 2024

Brain Sciences

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In this narrative review, we delve into the evolving concept of brain health, as recognized by the WHO, focusing on its intersection with cognitive decline. We emphasize the imperative need for preventive strategies, particularly in older adults. We describe the target population that might benefit the most from risk-based approaches—namely, people with subjective cognitive decline. Additionally, we consider universal prevention in cognitively unimpaired middle-aged and older adults. Delving into multidomain personalized preventive strategies, we report on empirical evidence surrounding modifiable risk factors and interventions crucial in mitigating cognitive decline. Next, we highlight the emergence of brain health services (BHS). We explain their proposed role in risk assessment, risk communication, and tailored interventions to reduce the risk of dementia. Commenting on ongoing BHS pilot experiences, we present the inception and framework of our own BHS in Monza, Italy, outlining its operational structure and care pathways. We emphasize the need for global collaboration and intensified research efforts to address the intricate determinants of brain health and their potential impact on healthcare systems worldwide.

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Poorer sleep impairs brain health at midlife

Cited by 10 publications

References 66 publications

Associations between sleep health and grey matter volume in the UK Biobank cohort (n= 33 356)

Associations between sleep health and grey matter volume in the UK Biobank cohort (n= 33 356)

Relationships between sleep duration and health among U.S. adults with a history of household incarceration during childhood.

Brain Health and Cognition in Older Adults: Roadmap and Milestones towards the Implementation of Preventive Strategies

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