2022
DOI: 10.1111/his.14809
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Poorly differentiated cutaneous apocrine carcinomas: histopathological clues and immunohistochemical analysis for the diagnosis of this unusual neoplasm

Abstract: Poorly differentiated cutaneous apocrine carcinomas: histopathological clues and immunohistochemical analysis for the diagnosis of this unusual neoplasm Primary cutaneous apocrine carcinoma (PCAC) is a rare cutaneous malignancy that is derived from apocrine glands. Histologically, these tumours can appear welldifferentiated where diagnosis should be relatively straightforward. However, occasionally these tumours can exhibit high-grade features, and in such instances the diagnosis can be challenging. A retrospe… Show more

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Cited by 4 publications
(2 citation statements)
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“…GTAT3 was not tested in this case. Currently, there is a shortage of diagnostic criteria for poorly differentiated PCAC [6]. For most cases, positive results were observed in GCDFP-15, CK7, and AR staining [12].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…GTAT3 was not tested in this case. Currently, there is a shortage of diagnostic criteria for poorly differentiated PCAC [6]. For most cases, positive results were observed in GCDFP-15, CK7, and AR staining [12].…”
Section: Discussionmentioning
confidence: 99%
“…In rare cases, PCAC exhibits a high level of invasiveness and rapid progression [4]. It is challenging to distinguish from metastatic breast carcinoma due to shared apocrine and immunohistochemical characteristics, such as the expression of CK7, GCDFP-15, GATA3, ER, PR, and mammaglobin [6]. This article reports a case of PCAC involving the parotid gland and discusses its differentiation from metastatic breast carcinoma and primary malignant tumors of the parotid gland.…”
Section: Introductionmentioning
confidence: 99%