Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?

Ricciardiello, Filippo; Falco, Michela; Tortoriello, Giuseppe; Riccardi, Ferdinando; Pellini, Raul; Iorio, Brigida; Russo, Giuseppe; Longo, Giuseppe; Coppola, Ciro; Takeuchi, Takashi; Grimaldi, Anna; Abate, Marianna; Scrima, Marianna; Cossu, Alessia Maria; Addeo, Raffaele; Ottaiano, Alessandro; Scarpa, Alfonso; Boscaino, Amedeo; Motta, G; Caraglia, Michele; Bocchetti, Marco; Misso, Gabriella

doi:10.3390/jcm10092019

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…Our patient showed moderate-to-severe cellular atypia and positivity for the neuroendocrine marker synaptophysin and epithelial marker CK7, which was consistent with the diagnosis of high-grade NEC [6] . Surgery combined with chemoradiotherapy is the main treatment strategy for NEC in the head and neck, and the prognosis is associated with the pathological type and differentiation of the tumor [17] . Esmati et al reported a patient with limited tongue NEC who underwent partial excision followed by chemoradiotherapy, without signs of recurrence at the approximately 5-year follow-up [5] .…”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT and PET/MRI fusion imaging for neuroendocrine carcinoma of the tongue: A case report

Zeng

Ling

Tang

et al. 2022

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT and PET/MRI fusion imaging for neuroendocrine carcinoma of the tongue: A case report

Zeng

Ling

Tang

et al. 2022

Radiology Case Reports

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“…In the future, different miRNA combinations may be able to detect different subtypes of PCOS. Additionally, studies demonstrated that miRNA expression had excellent prognostic scores only when discovered in early-stage of cancer [35,36]. The microRNA signatures may also help to identify these women in early stage and change treatment regimens in timely manner, when women respond poorly to progestin-based therapy leading to low currency of PCOS and hirsutism and acne [37].…”

Section: Discussionmentioning

confidence: 99%

How close are we to diagnosing Polycystic ovary syndrome with miRNAs: A Meta-analysis and review

Liu¹,

J²,

Wang³

et al. 2021

Preprint

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Objective: To investigate the accuracy of miRNA in the diagnosis of patients with Polycystic ovary syndrome (PCOS). Design: Systematic review and meta-analysis of controlled trials. Setting: Not applicable. Patient(s): Individuals with PCOS and control. Intervention(s): Summary sensitivity and specificity and positive and negative likelihood ratios (LRs) a random effects model were employed. Main Outcome Measure(s): Accuracy of miRNAs as diagnostic indicators. Result(s): The analysis showed that miRNA signiﬁcantly increased the accuracy of the diagnosis of PCOS, which included 9 articles with 1303 patients. The pooled sensitivity and specificity of miRNAs in the diagnosis of PCOS were 0.73 and 0.81, respectively. Multiple RNAs as biomarkers in qRT-PCR (SYBR) method showed higher sensitivity when compared to a single RNA and the Area Under Curve (AUC) was up to 0.88. Conclusions: MiRNAs may increase the accuracy of diagnosis and short the time required for diagnosis. Multiple miRNAs in SYBR method have good discriminating ability as biomarker for diagnosis.

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“…Precision medicine has recently concentrated on the outstanding opportunities resulting from the potential to restore homeostatic miRNA levels to their therapeutic potential. This is tied to peculiar and specific patient profiles [69].…”

Section: Poorly Differentiated Neuroendocrine Larynx Carcinomamentioning

confidence: 99%

Precision Medicine in Oral Health and Diseases: A Systematic Review

Malcangi

Patano

Guglielmo

et al. 2023

JPM

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Precision medicine (PM) is personalized medicine that can develop targeted medical therapies for the individual patient, in which “omics” sciences lead to an integration of data that leads to highly predictive models of the functioning of the individual biological system. They enable rapid diagnosis, assessment of disease dynamics, identification of targeted treatment protocols, and reduction of costs and psychological stress. “Precision dentistry” (DP) is one promising application that need further investigation; the purpose of this paper is therefore to give physicians an overview of the knowledge they need to enhance treatment planning and patient response to therapy. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases by analyzing the articles examining the role of precision medicine in dentistry. PM aims to shed light on cancer prevention strategies, by identifying risk factors, and on malformations such as orofacial cleft. Another application is pain management by repurposing drugs created for other diseases to target biochemical mechanisms. The significant heritability of traits regulating bacterial colonization and local inflammatory responses is another result of genomic research, and is useful for DP in the field of caries and periodontitis. This approach may also be useful in the field of orthodontics and regenerative dentistry. The possibility of creating an international network of databases will lead to the diagnosis, prediction, and prevention of disease outbreaks, providing significant economic savings for the world’s health care systems.

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Poorly Differentiated Neuroendocrine Larynx Carcinoma: Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?

Cited by 9 publications

References 34 publications

18F-FDG PET/CT and PET/MRI fusion imaging for neuroendocrine carcinoma of the tongue: A case report

18F-FDG PET/CT and PET/MRI fusion imaging for neuroendocrine carcinoma of the tongue: A case report

How close are we to diagnosing Polycystic ovary syndrome with miRNAs: A Meta-analysis and review

Precision Medicine in Oral Health and Diseases: A Systematic Review

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