Poorly formed hepatic granulomas: a rare manifestation of acute T cell‐mediated rejection

Rais, Rehan; Chatterjee, Deyali; McHenry, Scott; Byrnes, Kathleen

doi:10.1111/his.14207

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Histopathology1

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2024

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Cited by 2 publications

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“…They may be found in immune-mediated conditions, PBC, DILI, or T-cell–mediated rejection after a liver transplant. 2 52 “Granulomatous inflammation” refers to an inflammatory reaction involving epithelioid cells when granulomas fail to form. 32 Epithelioid granulomas that are not associated with a known etiology should be stained for infectious organisms.…”

Section: Histopathologymentioning

confidence: 99%

Granulomatous liver diseases

Mironova,

Gopalakrishna,

Rodriguez Franco

et al. 2024

Hepatology Communications

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A granuloma is a discrete collection of activated macrophages and other inflammatory cells. Hepatic granulomas can be a manifestation of localized liver disease or be a part of a systemic process, usually infectious or autoimmune. A liver biopsy is required for the detection and evaluation of granulomatous liver diseases. The prevalence of granulomas on liver biopsy varies from 1% to 15%. They may be an incidental finding in an asymptomatic individual, or they may represent granulomatous hepatitis with potential to progress to liver failure, or in chronic disease, to cirrhosis. This review focuses on pathogenesis, histological features of granulomatous liver diseases, and most common etiologies, knowledge that is essential for timely diagnosis and intervention.

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Section: Histopathologymentioning

confidence: 99%