2023
DOI: 10.21203/rs.3.rs-2543095/v1
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Pop-off mechanisms as renoprotective mediators in children with posterior urethral valves: A systematic review and meta-analysis

Abstract: Background Pop-off mechanisms are potential pressure-relieving mediators in patients diagnosed with posterior urethral valves (PUV). These mechanisms include, among others, urachal persistence, urinomas, bladder diverticula and unilateral high-grade vesicoureteral reflux. The aim of this systematic review was to synthesize the existing evidence regarding the protective effect of pop-off mechanisms on renal function in children with PUV. Methods We conducted a systematic review of the literature that involved… Show more

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Cited by 2 publications
(3 citation statements)
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“…Lastly, the cecal appendix contains a significant representation of lymphoid tissue. Because of these two aspects, the reaction to allergen exposure may be more accentuated in this organ than in the rest of the body [7,8]. This review aims to compile and meta-analyze the existing evidence on the role of type I hypersensitivity reactions in the development of AA.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Lastly, the cecal appendix contains a significant representation of lymphoid tissue. Because of these two aspects, the reaction to allergen exposure may be more accentuated in this organ than in the rest of the body [7,8]. This review aims to compile and meta-analyze the existing evidence on the role of type I hypersensitivity reactions in the development of AA.…”
Section: Introductionmentioning
confidence: 99%
“…Likewise, the appendix is a structure rich in enterochromaffin cells (especially at the level of the lamina propria). These cells store and secrete serotonin, a neurotransmitter that modulates peripheral immune system responses [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…Regarding the non-invasive diagnosis of AA, the existing literature is scarce. Recently, a systematic review and meta-analysis on the role of urinary LRG1 as a diagnostic test in pediatric AA was published, and although the evidence was heterogeneous and limited, it appears that this molecule is emerging as a promising diagnostic test in this subpopulation [12].…”
Section: Introductionmentioning
confidence: 99%