Popliteal artery thrombosis in a patient with Cogan syndrome: Treatment with thrombolysis and percutaneous transluminal angioplasty

Bastug, Demir E.; Dominic, Anthony J.; Ortiz, Orlando; DiBartolomeo, Anthony G.; Kotzan, Jeffrey M.; Abraham, F. Matthew

doi:10.1007/s002709900110

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…In these patients, arteriography can reveal embolic or thrombotic phenomena in the background of profound arterial stenosis, as was observed in our patient. Given our patient’s underlying CS, lifelong anticoagulation would also be required [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Limb Ischemia in Cogan Syndrome

Mohseni

2022

Am J Case Rep

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Patient: Male, 50-year-old Final Diagnosis: Cogan’s Syndrome • vascular ischemia • vasculitis Symptoms: Change in extremity temperature • extremity pain • pulselessness Medication: — Clinical Procedure: — Specialty: General and Internal Medicine • Rheumatology Objective: Rare disease Background: Cogan syndrome is a rare autoimmune disorder associated most frequently with ocular, vestibular, and auditory involvement from presumed small vessel vasculitis. Cogan syndrome, in a significant proportion of patients, can progress to systemic symptoms, including gastrointestinal, neurologic, and musculoskeletal manifestations. Large-vessel involvement has also been described in some cases (eg, aortitis), but acute limb ischemia in the setting of this illness has been infrequently reported. Case Report: We present a rare case of Cogan syndrome complicated by acute vascular ischemia of the left upper extremity. A 50-year-old man presented with symptoms of severe acute pain and weakness of the left arm. The patient endorsed a diagnosis of Cogan syndrome 4 years prior in the setting of unilateral left-sided hearing loss and bilateral uveitis. A physical examination revealed pallor of the left forearm and pulselessness at the wrist. Computed tomography angiography was suggestive of vasculitis and concerns for embolic occlusion of several arterial structures of the left upper limb. After consultation with various specialists, the patient was treated with high-dose steroids, anticoagulants, and topical nitroglycerin and experienced significant clinical improvement. Conclusions: Treatment of Cogan syndrome with severe systemic manifestations depends on the organ involvement and degree of extension. Our patient’s presentation serves as an impressive example of systemic vasculitis with subsequent acute ischemia in the setting of this rare autoimmune disorder. In such a case, given the potential for life- or limb-threatening systemic vascular catastrophes, emergent interventions (including imaging, anticoagulation, and specialist involvement) are required to prevent untoward outcomes.

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Section: Discussionmentioning

confidence: 99%

Acute Limb Ischemia in Cogan Syndrome

Mohseni

2022

Am J Case Rep

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“…Balloon angioplasty or stent placement and lysis of thrombus are alternative endovascular techniques (Allen et al 1990;Bastug et al 1997). Such occlusive lesions amenable to endovascular treatment may occur in any primary or secondary artery (Vollertsen et al 1986;Allen et al 1990;Thomas 1992;Vella et al 1997;Tseng et al 1999;Bisdas et al 2009).…”

Section: Surgery and Endovascular Treatmentmentioning

confidence: 96%

Cogan’s Syndrome

Matteson¹,

Stanson²

2011

Systemic Vasculitis

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“…Moreover, antiphospholipid syndrome (APS) can occur concomitantly with vasculitis secondary to systemic autoimmune disease (frequently SLE), and can develop into catastrophic APS [66][67][68][69][70][71][72][73] (Figure 10). Certain kinds of vasculitis can be complicated by thrombosis and potentially develop into thrombotic storm which has a devastating clinical course [74][75][76][77]. Radiation arteritis can occur years after high-dose radiotherapy for pelvic malignant disease.…”

Section: Other Vasculitidesmentioning

confidence: 99%

Nonatherosclerotic Peripheral Artery Disease

Kawarada¹

2017

Angiography and Endovascular Therapy for Peripheral Artery Disease

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Nonatherosclerotic peripheral artery disease (NAPAD) remains underappreciated compared to atherosclerotic peripheral artery disease. However, under-or misdiagnosis of NAPAD can potentially lead to serious adverse outcomes. There is a broad spectrum of disorders including vasculitis, thrombophilia, and other vascular anatomical or functional disorders in the context of NAPAD. This section briefly overviews vascular imaging, mainly invasive angiography, to optimize the management of NAPAD.

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Popliteal artery thrombosis in a patient with Cogan syndrome: Treatment with thrombolysis and percutaneous transluminal angioplasty

Cited by 5 publications

References 11 publications

Acute Limb Ischemia in Cogan Syndrome

Acute Limb Ischemia in Cogan Syndrome

Cogan’s Syndrome

Nonatherosclerotic Peripheral Artery Disease

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