POPS case: A 30-year-old Filipino woman with fevers, lymphadenopathy, painful scalp lesions, and a neck mass

Abstract

<jats:p>We described a case of a 30-year-old Filipino woman who presented with fevers, night sweats, left hip pain, painful scalp lesions, and a neck mass. Symptoms began 6 months earlier, with nasal drainage, fever, cough, and occasional hemoptysis, which did not resolve with outpatient antibiotics. A further workup revealed lymphadenopathy and several lytic bone lesions. Her hospital course was later further complicated by the development of a tracheoesophageal fistula secondary to an esophageal mass and, then later, aseptic meningitis. Extensive diagnostic workup and immunologic tests were performed and finally led to the diagnosis. Here, we discussed the diagnostic workup and pathophysiology of the underlying condition. This case illustrated the importance of appropriate immunologic workup to make the diagnosis of a rare condition that proves to be clinically significant and presents challenges in management.</jats:p>

Characteristics and Outcomes of Anti-interferon Gamma Antibody-Associated Adult Onset Immunodeficiency

“…After excluding 3 patients without documented RTX effects, and one patient receiving RTX before the diagnosis [ 17 ], the general effective rate of RTX was 73.5% (25/34). Four patients had only partial remission [ 14 , 21 , 25 ], and another three patients had progressive infection even after RTX treatment [ 21 , 26 ]. Two patients failed RTX but achieved disease control with bortezomib [ 22 ] or daratumumab [ 27 ].…”

COVID-19, allergic disease and asthma: Extraordinary challenges for the allergist/immunologist

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