1998
DOI: 10.1046/j.1461-0248.1998.00018.x
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Population and transmission dynamics of cowpox in bank voles: testing fundamental assumptions

Abstract: The idea that the rate of production of new infections, of directly transmitted microparasites, is a reflection of an interaction between the number of infectious hosts and the number of susceptible hosts in a population is central to our understanding of dynamical processes in epidemiology. Empirical support for the idea has been seriously lacking, especially for endemic infections in natural hosts, but is provided here for cowpox virus infection in bank voles (Clethrionomys glareolus), using alternative desc… Show more

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Cited by 59 publications
(59 citation statements)
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“…These results therefore contrast with, but cannot contradict, previous attempts to infer a transmission function for cowpox virus infection in wild rodents (18,19), because these simply compared density and frequency dependence (with results tending to support the latter). The key contrasts between the present study and those done previously are the improved quality and quantity of data and the improved methodology for estimating parameter values and functional forms.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…These results therefore contrast with, but cannot contradict, previous attempts to infer a transmission function for cowpox virus infection in wild rodents (18,19), because these simply compared density and frequency dependence (with results tending to support the latter). The key contrasts between the present study and those done previously are the improved quality and quantity of data and the improved methodology for estimating parameter values and functional forms.…”
Section: Discussioncontrasting
confidence: 99%
“…Here, we focus on the nature of the density dependence in the standard transmission rate function, because relationships varying in this respect have the most transparent biological meaning, and this ties our work to the overriding majority of previous (mainly theoretical) studies. The few empirical studies (18)(19)(20)(21), lacking the methodologies developed here and with comparatively few data, have been limited to simple comparisons of density and frequency dependence.…”
Section: [1]mentioning
confidence: 99%
“…In Cheshire, bank voles and wood mice were trapped in woodland on a monthly basis as part of a long-term study of host-pathogen dynamics (2,3,5,8), but for most of this time TB was not suspected and therefore was not monitored. On the basis of the results from Kielder, however, TB-like skin lesions were removed from five animals (three bank voles and two wood mice) in 1998 and 1999 for laboratory analysis.…”
Section: Methodsmentioning
confidence: 99%
“…As explained fully elsewhere (Begon et al 1998), the changing numbers of seroconverters in the populations can be interpreted in the light of the observation that infected animals remain infected (and therefore, to some degree, infectious) for approximately four weeks and seroconversion occurs approximately halfway through this period. This allowed the number of new infections, I(t, t + 1), the average number of susceptible hosts, S(t), and the average number of infectious hosts, I(t), to be estimated for both species in both populations for each inter-sample period.…”
Section: (B) Datamentioning
confidence: 99%