Population‐attributable risk of modifiable lifestyle factors to hepatocellular carcinoma: The multi‐ethnic cohort

Zhou, Kali; Lim, Tiffany; Dodge, Jennifer L.; Terrault, Norah A.; Wilkens, Lynne R.; Setiawan, Veronica Wendy

doi:10.1111/apt.17523

Cited by 3 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And the latest prospective analysis also confirmed that coffee drinking this lifestyle factors and the incidence of HCC is closely related to the lower risk. 13 The last review on this field was published by Kennedy's research team in 2017. 14 We decided to update the data in this field and synthesize information that includes the pathophysiological mechanisms, results of experimental and clinical studies, mechanisms of drug resistance and ways to overcome them, adverse effects of caffeine, recent patents in this field, and future developments.…”

Section: Introductionmentioning

confidence: 99%

Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation

Shan,

Zhao,

Wang

et al. 2024

JIR

View full text Add to dashboard Cite

The use of caffeine in treating various liver diseases has made substantial progress in the past decade owing to advances in science, technology, and medicine. However, whether caffeine has a preventive effect on hepatocellular carcinoma (HCC) and its mechanism are still worth further investigation. In this review, we summarize and analyze the efficacy and safety of caffeine in the prevention of HCC. We conducted a review of articles published in PubMed and Web of Science in the past 2 decades until December 6, 2023, which were searched for using the terms "Caffeine" and "Hepatocellular Carcinoma." Studies have found that coffee intake is negatively correlated with HCC risk, especially caffeinated coffee. Recent studies have found that caffeine has beneficial effects on liver health, decreasing levels of enzymes responsible for liver damaging and slowing the progression of hepatic fibrosis and cirrhosis. Caffeine also acts against liver fibrosis through adenosine receptors (ARs), which promote tissue remodeling by inducing fibrin and collagen production. Additionally, new studies have found that moderate consumption of caffeinated beverages can decrease various the levels of various collagens in patients with chronic hepatitis C. Furthermore, polyphenolic compounds in coffee can improve fat homeostasis, reduce oxidative stress, and prevent liver steatosis and fibrosis. Moreover, many in vitro studies have shown that caffeine can protect liver cells and inhibit the activation and proliferation of hepatic stellate cells. Taken together, we describe the benefits of caffeine for liver health and highlight its potential values as a drug to prevent various hepatic diseases. As a protective agent of liver inflammation, non-selective AR inhibitor caffeine can inhibit the growth of HCC cells by inhibiting adenosine and AR binding to initiate immune response, providing a basis for the future development of caffeine as an adjuvant drug against HCC.

show abstract

Section: Introductionmentioning

confidence: 99%

Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation

Shan,

Zhao,

Wang

et al. 2024

JIR

View full text Add to dashboard Cite

show abstract

Cancers attributable to diet in Italy

Turati,

Alicandro,

Collatuzzo

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

Cancer burden can be reduced by controlling modifiable risk factors, including diet. We provided an evidence‐based assessment of cancer cases and deaths attributable to diet in Italy in 2020. We considered dietary factor‐cancer type pairs for which the World Cancer Research Fund/American Institute for Cancer Research – Continuous Update Project reported either ‘convincing’ or ‘probable’ evidence of causal association. Relative risks were retrieved from recent meta‐analyses and dietary intakes (around 2005) from a national food consumption survey. Sex‐specific population attributable fractions (PAFs) were computed by comparing the distribution of dietary intakes in the Italian population against counterfactual scenarios based on dietary recommendations. Using data from national cancer and mortality registries in 2020, we estimated the number of attributable cancer cases and deaths, assuming ~15‐year lag period. Unhealthy diet accounted for 6.3% (95% CI: 2.5%–9.9%) of all cancer cases in men and 4.5% (95% CI: 1.7%–7.4%) in women. PAFs of colorectal cancer were 10.5% and 7.0% for any intake of processed meat, 3.3% and 2.0% for high red meat, 4.8% and 4.3% for low dairy products, and 7.9% and 9.0% for low fiber intakes in men and women, respectively. PAFs for low intake of non‐starchy vegetables and fruit ranged from 0.8% to 16.5% in men and 0.6%–17.8% in women for cancers of the aerodigestive tract. The estimated cancer burden associated with unfavorable dietary habits in Italy is considerable, but appears lower than for other high‐income countries, reflecting the typically Mediterranean diet.

show abstract

The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease

Maćków,

Dziubyna,

Jamer

et al. 2024

Nutrients

View full text Add to dashboard Cite

Background: Liver diseases are among the most commonly diagnosed conditions, with the main risk factors being inappropriate lifestyles, including poor diet, excessive alcohol consumption, low physical activity and smoking, including electronic cigarettes. Non-communicable chronic liver diseases also often develop as a result of accompanying overweight and obesity, as well as type 2 diabetes. Methods: The literature on risk factors for non-communicable chronic liver diseases, which show a high strong influence on their occurrence, was analysed. Results: Measures to prevent non-communicable chronic liver disease include the selection of suitable food ingredients that have proven protective effects on the liver. Such ingredients include dietary fibre, probiotics, herbs, various types of polyphenols and fatty acids (omega-3). Conclusions: Because of their liver-protective effects, nutritionists recommend consuming vegetables, fruits, herbs and spices that provide valuable ingredients with anti-inflammatory and anti-cancer effects. These components should be provided with food and, in the case of probiotics, supplementation appears to be important. As a preventive measure, a diet rich in these nutrients is therefore recommended, as well as one that prevents overweight and other diseases that can result in liver disease.

show abstract

Population‐attributable risk of modifiable lifestyle factors to hepatocellular carcinoma: The multi‐ethnic cohort

Cited by 3 publications

References 40 publications

Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation

Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation

Cancers attributable to diet in Italy

The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease

Contact Info

Product

Resources

About