Population-based approaches to genetics of migraine

Chasman, Daniel I.; Schürks, Markus; Kurth, Tobias

doi:10.1177/0333102416638519

Cited by 10 publications

(11 citation statements)

References 106 publications

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“…These public–private partnerships should be encouraged in future studies as they benefit all interested parties, and the pooling of all available resources can only help speed up new discoveries. Of course, it should be remembered that the contributions from academic or clinical institutions are equally important because these tend to consist of more severe cases and better phenotyped collections that can also improve power and enable more detailed follow-up questions to be investigated [5]. …”

Section: Understanding the Polygenic Basis Of Migrainementioning

confidence: 99%

Migraine genetics: from genome-wide association studies to translational insights

et al. 2016

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Section: Understanding the Polygenic Basis Of Migrainementioning

confidence: 99%

Migraine genetics: from genome-wide association studies to translational insights

et al. 2016

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“…65 However, population-based studies such as the CLSA have other strengths, including high statistical power given the large sample surveyed. Therefore, it should be noted that our population-based ascertainment of migraine is both less precise and likely more heterogeneous than if the gold standard of classification using specific diagnostic criteria were utilized.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it should be noted that our population-based ascertainment of migraine is both less precise and likely more heterogeneous than if the gold standard of classification using specific diagnostic criteria were utilized. 65 However, population-based studies such as the CLSA have other strengths, including high statistical power given the large sample surveyed.…”

Section: Discussionmentioning

confidence: 99%

Health Behaviors and Social Determinants of Migraine in a Canadian Population‐Based Sample of Adults Aged 45‐85 Years: Findings From the CLSA

Hammond

Stinchcombe

2019

Headache

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Background Social determinants of health are well linked to adverse health outcomes, but less is known about how they relate to migraine. While much attention has been given to the role of modifiable lifestyle factors which may mitigate risk of migraine, the role of physical activity in headache management is not yet understood. Objectives The purpose of this study was to explore the relationship between social determinants of health, health behaviors, and migraine prevalence in a sample of the Canadian population aged 45‐85 years. Methods In this cross‐sectional analysis of baseline data from the Canadian Longitudinal Study on Aging, respondents were between 45 and 85 years of age and migraine was self‐report of physician diagnosis. Analyses were stratified by sex/gender (nwomen = 22,176, nmen = 21,549). Results The weighted prevalence of migraine for men and women was 7.5% and 19.6%, respectively. There were relationships between social determinants of health and migraine for both men and women. Notably, higher perceived social status was associated with a 3% reduced odds of migraine among women (OR = 0.97, 95% CI: 0.95, 0.98, P < .001). Gay and bisexual men had 50% higher odds of migraine compared to heterosexual men (OR = 1.50, 95% CI: 1.13, 1.99, P = .005). Some forms of physical activity were associated with reduced odds of migraine for women: walking for 30 minutes but less than 1 hour (OR = 0.87, 95% CI: 0.78, 0.96, P = .005), light sports for less than 30 minutes (OR = 0.86, 95% CI: 0.73, 1.00, P = .048), and 1 hour but less than 2 hours (OR = 0.85, 95% CI: 0.74, 0.97, P = .018), strenuous sports for 30 minutes but less than 1 hour (OR = 0.79, 95% CI: 0.71, 0.89, P < .001), and 1 hour but less than 2 hours (OR = 0.82, 95% CI: 0.73, 0.92, P = .001). Men who engaged in daily walking as a form of leisure time physical activity had higher odds of migraine: walking less than 30 minutes (OR = 1.21, 95% CI: 1.01, 1.45, P = .042), 2 hours but less than 4 hours (OR = 1.42, 95% CI: 1.11, 1.80, P = .005), and 4 hours or more (OR = 1.65, 95% CI: 1.18, 2.31, P = .004). Conclusions Social determinants of health are associated with migraine prevalence for both men and women. Physical activity is a modifiable lifestyle factor which merits further exploration as an intervention option for migraine headaches in aging samples, especially among older women. Greater odds of migraine among older men who walked for exercise may be explained by reverse causality.

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“…Despite extensive research, its pathomechanism is still questionable. Migraine is heritable with estimated values of 0.34-0.57 (Chasman et al, 2016) reflecting an important role of environmental factors, also. A large number of genes of small effects appear to be involved in migraine (Anttila et al, 2013;Gormley et al, 2016), and their interactions with environmental factors have also been suggested (Sauro and Becker, 2009;Juhasz et al, 2017) but there is a significant lack of gene × environment interaction studies of migraine.…”

Section: Introductionmentioning

confidence: 99%

Financial Stress Interacts With CLOCK Gene to Affect Migraine

Baksa

Gonda

Eszlári

et al. 2020

Front. Behav. Neurosci.

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Population-based approaches to genetics of migraine

Abstract: We argue that the detailed genetic architecture of migraine, various aspects of methodology, and the ultimate sample size achieved by population-based ascertainment will be critical determinants of the future success of this approach to genetic analysis of migraine and its comorbidities.

Cited by 10 publications

References 106 publications

Migraine genetics: from genome-wide association studies to translational insights

Migraine genetics: from genome-wide association studies to translational insights

Health Behaviors and Social Determinants of Migraine in a Canadian Population‐Based Sample of Adults Aged 45‐85 Years: Findings From the CLSA

Financial Stress Interacts With CLOCK Gene to Affect Migraine

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