Population-based epidemiologic data on brain tumors in German children

Kaatsch, Peter; Rickert, Christian H.; Kühl, Joachim; Schüz, Joachim; Michaelis, Jörg

doi:10.1002/1097-0142(20011215)92:12<3155::aid-cncr10158>3.0.co;2-c

Cited by 279 publications

(169 citation statements)

References 25 publications

(22 reference statements)

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“…7,10,13,14 The absence of low occurrence or absence of paediatric tumors in our study population is certainly notable, however, as the total number of paediatric patients in the sample group was relatively small, no firm conclusions can be drawn in this matter.…”

Section: Discussionmentioning

confidence: 79%

Central nervous system tumors: a histopathological study

et al. 2016

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Section: Discussionmentioning

confidence: 79%

Central nervous system tumors: a histopathological study

et al. 2016

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“…Most previous studies (Mosso et al, 1992;Linet et al, 1999;Kaatsch et al, 2001;Gonzalez et al, 2004), but not all (Shugg et al, 1994) have found decreases in mortality from CNS tumours in childhood over the past three decades, probably owing to improved therapy. In the present study, however, we observed an annual 1.4% increase in mortality rate (younger children 1.8%; older children 1.3%), which indeed supports that the observed annual 2.9% increase in incidence rate (younger children: 3.7%; older children: 2.4%) is biologically true.…”

Section: Discussionmentioning

confidence: 94%

Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980–1996

et al. 2006

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The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 1996. Population-based registers were used to extract data on mortality and background population. Temporal patterns were analysed by regression techniques. Most tumours were verified by computed tomography (78%) or magnetic resonance imaging (14%). Overall, the incidence rate increased by 2.9% per year (95% confidence interval (CI): 1.3;4.5) and the mortality rate increased by 1.4% per year (95% CI: À0.4;3.3). Among children aged 0 -4 years, the survival rate after diagnosis remained almost unchanged, whereas among children aged 5 -14 years, the 10-year survival rate improved from 59 to 74%. These data suggest that the incidence rate of CNS tumours among Danish children has truly increased, although alternative explanations cannot be excluded.

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“…2 Although ependymomas are fairly frequent brain tumors, in particular, in the pediatric population where they are the third most common entity and account for approximately 10% of cases, 3 the clear cell variety is exceedingly rare and diagnostically challenging. [4][5][6][7] Not surprisingly, only one study investigating the genetic properties of clear cell ependymomas has been undertaken by using fluorescence in situ hybridization (FISH) on 10 cases.…”

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confidence: 99%

Chromosomal imbalances in clear cell ependymomas

2006

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Clear cell ependymoma is a rare and diagnostically challenging subtype of ependymoma, whose genetic features are essentially unknown. We studied 13 clear cell ependymomas (five cases WHO grade II, eight cases WHO grade III) by comparative genomic hybridization (CGH). Chromosomal imbalances were found in 12/13 cases. The most common aberrations overall were þ 1q (38%), À9 (77%), À3 (31%), and À22q (23%). Clear cell ependymomas of WHO grade II were characterized by À9 (40%), whereas WHO grade III cases mainly showed þ 1q (63%), and þ 13q (25%), as well as À9 (100%), À3 (38%), and À22q (25%). In contrast to other ependymal tumors, clear cell ependymomas of WHO grade II showed fewer imbalances than WHO grade III samples (1.4 vs 3.5 per case). Although some of the implicated chromosomes have previously been shown to be involved in other ependymoma variants, the striking frequency of þ 1q, À9, and À3 suggests that aberrations differ between clear cell and other types of ependymomas, in particular, for loss of chromosome 9 which can be regarded as the molecular hallmark of clear cell ependymomas. Modern Pathology (2006) 19, 958-962.

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Population-based epidemiologic data on brain tumors in German children

Cited by 279 publications

References 25 publications

Central nervous system tumors: a histopathological study

Central nervous system tumors: a histopathological study

Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980–1996

Chromosomal imbalances in clear cell ependymomas

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