Population‐based erythrocyte sedimentation rates in 3910 subjectively healthy Norwegian adults. A statistical study based on men and women from the Oslo area

Wetteland, P; Roger, Michel; Solberg, Helge Erik; Iversen, Olav Hilmar

doi:10.1046/j.1365-2796.1996.30295851000.x

Cited by 35 publications

(42 citation statements)

References 9 publications

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“…The test measures the distance erythrocytes fall after an hour in a vertical column of anticoagulated blood under the influence of gravity (Saadeh, 1998). The basic factors influencing the ESR have been understood since the early part of this century; the amount of fibrinogen in the blood directly correlates with the ESR (Wetteland et al, 1996). There are two main methods of performing the ESR; the Wintrobe and Westergren method (Lewis et al, 2006).…”

mentioning

confidence: 99%

Comparative Study of Erythrocyte Sedimentation Rate (ESR) Using Trisodium Citrate, Normal Saline and Whole Blood in Ethylene Di Amine Tetra Acetic Acid (EDTA)

Emelike¹,

Akpan²,

Obigwe³

et al. 2010

Journal of Applied Sciences and Environmental Management

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Erythrocyte sedimentation rate (ESR) was carried out on 200 apparently healthy individuals (131 males and 69 females) in Ekpoma using trisodium citrate, normal saline diluents and whole blood suspension in EDTA without any diluents. The Westergren method was adopted for this study as recommended by the International Committee for Standardization in Haematology (ICSH). The tests were read at 30 minutes and 1 hour intervals and results recorded as mm in 30mins and mm in 1hr respectively. The Mean ± SD of ESR values in males using trisodium citrate and normal saline were 11.99±9.48 and 12.12±9.46, while for females it was 13.69±8.5 and 13.97±8.97 respectively. This difference was statistically significant (P< 0.05). There was also a statistically significant difference between the ESR values obtained using trisodium citrate and whole blood (P< 0.05). Males had lower ESR values compared to females. There was a statistically significant difference between the ESR values obtained in 30mins and 1hour (P< 0.05). In conclusion, the use of normal saline and whole blood cannot be a good substitute for trisodium citrate in estimating ESR. Secondly, ESR is time dependent; therefore, the conventional time of 1 hour should be maintained. @ JASEM

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confidence: 99%

Comparative Study of Erythrocyte Sedimentation Rate (ESR) Using Trisodium Citrate, Normal Saline and Whole Blood in Ethylene Di Amine Tetra Acetic Acid (EDTA)

Emelike¹,

Akpan²,

Obigwe³

et al. 2010

Journal of Applied Sciences and Environmental Management

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“…A population study of 3,910 healthy Norwegian adults found that the upper reference levels expected to be exceeded by chance 5% of the time were 19 mm h -1 for men and 23 mm h -1 for women over the age of 90 years [18]. Using that criterion, all but 1 patient in our series would have had an elevated ESR.…”

Section: Discussionmentioning

confidence: 83%

Studies on the Histopathology of Temporal Arteritis

et al. 2016

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Aims: The aim of this paper was to identify the location and to grade the severity of most significant inflammation within positive temporal artery biopsies along with other key clinical and histologic characteristics. Methods: Charts and pathology slides for 70 patients diagnosed with temporal arteritis at the University of Wisconsin (UW) Hospital and Clinics from 1989 to 2015 were reviewed. A subset of 48 specimens was immunostained for CD68 and graded on a scale from 0 to +++; the location of staining was recorded. Results: The most severe granulomatous inflammation was in the media and adventitia in 13% (9/70) of the biopsies; the remaining had uniform full thickness inflammation. Of the slides that were stained with CD68, 94% (45/48) were positive. In 42% (19/45), the stained cells were found mainly in the muscularis and adventitia. Seven percent (3/45) of the slides had staining solely around the internal elastic lamina, and 2% (1/45) had staining limited to the intima. Conclusions: With a few exceptions, granulomatous inflammation in positive temporal artery biopsies is most evident at the media and adventitia or is uniform throughout the layers of the artery. Our study lends support to the theory that the muscularis and adventitia may play an inciting role in the pathogenesis of temporal arteritis.

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“…The order of theoretical sedimentation rate agrees with that from other clinical reports. 5,44,45 In our design, the height of the separation chamber (H ch ) is around 80 lm, which will take roughly 100 s for all the RBCs to settle down near the bottom of the separation chamber (t s % 100 s). The flow rate of all the devices in case I was kept the same (Q % 2.5 nl/s), and the volume of the separation chamber (V s ) is around 10 9 lm 3 .…”

Section: Blood Sedimentationmentioning

confidence: 99%

Phaseguide-assisted blood separation microfluidic device for point-of-care applications

Lee

Pinheiro

et al. 2015

Biomicrofluidics

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We propose a blood separation microfluidic device suitable for point-of-care (POC) applications. By utilizing the high gas permeability of polydimethylsiloxane (PDMS) and phaseguide structures, a simple blood separation device is presented. The device consists of two main parts. A separation chamber with the phaseguide structures, where a sample inlet, a tape-sealed outlet, and a dead-end ring channel are connected, and pneumatic chambers, in which manually operating syringes are plugged. The separation chamber and pneumatic chambers are isolated by a thin PDMS wall. By manually pulling out the plunger of the syringe, a negative pressure is instantaneously generated inside the pneumatic chamber. Due to the gas diffusion from the separation chamber to the neighboring pneumatic chamber through the thin permeable PDMS wall, low pressure can be generated, and then the whole blood at the sample inlets starts to be drawn into the separation chamber and separated through the phaseguide structures. Reversely, after removing the tape at the outlet and manually pushing in the plunger of the syringe, a positive pressure will be created which will cause the air to diffuse back into the ring channel, and therefore allow the separated plasma to be recovered at the outlet on demand. In this paper, we focused on the study of the plasma separation and associated design parameters, such as the PDMS wall thickness, the air permeable overlap area between the separation and pneumatic chambers, and the geometry of the phaseguides. The device required only 2 ll of whole blood but yielding approximately 0.38 ll of separated plasma within 12 min. Without any of the requirements of sophisticated equipment or dilution techniques, we can not only separate the plasma from the whole blood for on-chip analysis but also can push out only the separated plasma to the outlet for off-chip analysis. V C 2015 AIP Publishing LLC.

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Population‐based erythrocyte sedimentation rates in 3910 subjectively healthy Norwegian adults. A statistical study based on men and women from the Oslo area

Cited by 35 publications

References 9 publications

Comparative Study of Erythrocyte Sedimentation Rate (ESR) Using Trisodium Citrate, Normal Saline and Whole Blood in Ethylene Di Amine Tetra Acetic Acid (EDTA)

Comparative Study of Erythrocyte Sedimentation Rate (ESR) Using Trisodium Citrate, Normal Saline and Whole Blood in Ethylene Di Amine Tetra Acetic Acid (EDTA)

Studies on the Histopathology of Temporal Arteritis

Phaseguide-assisted blood separation microfluidic device for point-of-care applications

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