Population‐based incidence and melanoma‐specific survival of cutaneous malignant melanoma in a Colombian population 2000–2009

Reyes, Evy; Uribe, Claudia; Vries, Esther de

doi:10.1111/ijd.13839

Cited by 22 publications

(46 citation statements)

References 19 publications

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“…Nevertheless, it's important to mention that in 24% of cases, the specific site of the tumour was not provided. Series from some Latin-American countries have shown nodular melanomas as the predominant subtype, followed by superficial spreading, acrolentiginous and lentigo melanomas [28,29]; or, followed by lentigo [23] or acrolentiginuous melanomas [30]. In this study, as for high CM incidence areas worldwide, the most frequent histology in the country, and for the Centro and Patagonia regions, was the SSM.…”

Section: Discussionmentioning

confidence: 62%

“…The primary location of melanomas differs between countries and populations. When analysing all RAMC cases together, regardless of gender, 28.6% of the lesions appeared in the trunk, as has been described in Spain [21] and Canada [22], but, for other Latin-American countries, the main location described was the lower limbs [23] or the face [24].…”

Section: Discussionmentioning

confidence: 65%

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Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Loria¹,

Abriata²,

Santoro³

et al. 2020

ecancer

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Purpose: This study aims to increase the knowledge about the characteristics of cutaneous melanoma in Argentina, their association with the risk of having Breslow ≥1 mm and mortality trends for the period 2002-2017.Patients and methods: Descriptive statistics and regression analyses were done for 10.199 cases within the Argentine Melanoma Registry in the period 2002-2018. Trends in age-standardised mortality rates (ASMR) were analysed using the Join point Regression Model.Results: Cases showed lesions mainly located in males' trunk (37%) and in females' lower limbs (29%). The level of invasion was higher in males who also showed higher mortality. Cases from the North West and North East regions showed a major risk of Breslow >1 mm and harboured CM in lower limbs more frequently than in other regions. Nearly, 25% of tumours over 2 mm were in cases aged <50 years and 37.6% in patients ≥50 years. In the North West, North East and Patagonia, the frequency of cases in young people was higher than in older people. In 43% of cases, the melanoma subtype was not specified in the report. The number of superficial spreading melanomas, the most common histology, was nearly twice that of Nodular melanomas the following histology in importance (3,403 and 1,754, respectively). Melanoma mortality rates in all Argentine population increased in the elderly. Lower melanoma mortality rates were observed in the North West. In 2007-2017, ASMR decreased significantly in females (average 1.4% p/year) while it increased nonsignificantly in males (0.4% p/year).The tumours with the worst prognosis were associated with the elderly, males, nodular or acrolentiginous morphologies, residing somewhere other than Centro and Patagonia and with tumors located in the head/neck and legs. Conclusion:The geographical variations found for melanoma characteristics and their mortality in Argentina, makes it imperative that epidemiological research is continued to avoid generalisations and improve future preventive actions.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 65%

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Loria¹,

Abriata²,

Santoro³

et al. 2020

ecancer

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“…Its high degree of malignancy and high tendency to metastasize result in an unfavorable prognosis, since the overall five-year survival rate for patients with more than three metastases to lymph nodes or distant organs is less than 16 %, representing 90 % of deaths associated with skin tumors [5][6][7] . Interestingly, in Colombian studies, the overall melanoma-specific five-year survival rate is substantially lower than that reported by countries with higher incidence 8 .…”

Section: Introductionmentioning

confidence: 68%

Melanoma: clinical-pathological and molecular analysis in patients of Ibague city, Colombia

Puentes

Estrada

Bohórquez

et al. 2020

Duazary

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This study aimed to establish the clinicopathological characteristics of patients with melanoma and its association with BRAF gene mutations. The pathology reports and paraffin-embedded tumor samples from 47 women and 30 men with melanoma, with an average age of diagnosis of 60 years, were reviewed at the Hospital Federico Lleras Acosta of Ibague, between 2010 and 2016. The presence of V600E mutation at the exon 15 of BRAF gene, was analyzed in these tumoral samples by Sanger sequencing and visual inspection of the electropherograms. We also studied the clinicopathological variables with X2, t-Student and the Kaplan Meier index. Most of the lesions were located in the lower limbs (46.6%). The most frequent subtype was Acral Lentiginous Melanoma (41.8%). Most lesions were of poor prognosis: Breslow depth greater than 4.1 mm (52.7%), ulceration (61.4%) and medium or high mitotic rate (> 30 %). The V600E mutation was identified in five patients with large, deep and ulcerated tumors, four of them had less than four years of survival. In conclusion, there was a higher frequency of melanoma in women, V600E BRAF mutation was present in patients with advanced disease (high Breslow index) and, the probability of five-year survival was less than 40%.

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“…Recently, molecular characterizations of ALM and mucosal melanoma (MCM) have shown that these clinical types are biologically distinct from the more common cutaneous melanomas. 6,7 Some reports indicated that these two subtypes correlated with poor survival, [8][9][10][11] while others have reported no correlation between clinical subtypes and prognosis. 12,13 The recent development of immune checkpoint inhibitors has dramatically changed the treatment of melanoma.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

Yoshikawa²,

et al. 2019

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Background The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large‐scale Asian studies that include follow‐up data have been reported. Objectives To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan‐Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease‐specific survival in patients with invasive melanoma. Results In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5‐year disease‐specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions Our study revealed the characteristics of melanoma in the Japanese population. The 5‐year disease‐specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.

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Population‐based incidence and melanoma‐specific survival of cutaneous malignant melanoma in a Colombian population 2000–2009

Cited by 22 publications

References 19 publications

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Cutaneous melanoma in Argentina: an analysis of its characteristics and regional differences

Melanoma: clinical-pathological and molecular analysis in patients of Ibague city, Colombia

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

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