Population-based incidence rates of malignant melanoma of the vulva in Germany

Stang, Andreas; Streller, B; Eisinger, B; Jöckel, Karl Heinz

doi:10.1016/j.ygyno.2004.09.052

Cited by 51 publications

(32 citation statements)

References 12 publications

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“…The sites of the female genitalia most commonly affected by melanoma include the labia and clitoris, 5,7,8 although the often multifocal nature of MFG may complicate designation of one specific anatomic site of origin. The multifocal nature of vulvar melanoma differs from cutaneous melanoma in this respect.…”

Section: Discussionmentioning

confidence: 99%

“…2,7 Although VMM acts biologically similar to cutaneous malignant melanoma, 4,8 much is still unknown about VMM as well as other rarer melanomas of the female genitalia, such as vaginal and cervical melanoma. We hope that review of our patients' characteristics and treatment practices will help add to the current knowledge on melanoma of the female genitalia (MFG).…”

Section: -6 Whilementioning

confidence: 99%

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Clinicopathologic study of 85 cases of melanoma of the female genitalia

Tcheung

Selim

Herndon

et al. 2012

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: -6 Whilementioning

confidence: 99%

Clinicopathologic study of 85 cases of melanoma of the female genitalia

Tcheung

Selim

Herndon

et al. 2012

Journal of the American Academy of Dermatology

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“…Estimation of the true incidence could only be obtained from population-based data. There were only a few reports on the incidence of vulvar and vaginal melanomas based on national surveys [9,13,28]. The population-based incidence per year of vulvar melanoma in the United States during 1973-1987 remained stable and averaged 1.08/million of the female population and 0.26/million in vaginal melanoma [13].…”

Section: Discussionmentioning

confidence: 99%

Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas

Hu¹,

McCormick³

2010

Melanoma Research

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Little is known on the difference in the incidence of vulvar and vaginal melanomas in various racial/ethnic groups. Population-based incidence of these melanomas in Asian and Hispanic individuals is almost unknown. Using 1992-2005 data provided by the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, we calculated age-adjusted incidence rates of vulvar and vaginal melanomas in various racial/ethnic groups. From 1992 to 2005, there were 324 vulvar melanomas and 125 vaginal melanomas diagnosed in this group. The annual age-adjusted incidence rates (per million female population) of vulvar and vaginal melanomas in the different racial/ethnic groups was 0.87 (Blacks), 0.75 (American-Indian), 1.03 (Asians and Pacific Islanders), 1.22 (Hispanics), and 1.90 (non-Hispanic Whites). The overall white/black incidence ratio in vulvar and vaginal melanomas was 3.14 : 1 and 1.02 : 1, respectively; which is much less than that of cutaneous melanoma (13 : 1-17 : 1) and uveal melanoma (18 : 1) and is similar to that of conjunctival melanoma (2.6 : 1) and other mucosal melanomas (2.1 : 1-2.3 : 1). The low racial difference in vulvar and vaginal melanomas (as well as conjunctival and other mucosal melanomas) may be determined by their microenvironment factors (all originate from mucosa or semi-mucosa tissues). The incidence of vulvar and vaginal melanomas has does not increased in recent decades or toward the south (more sun exposure), indicating that ultraviolet radiation is not a causative factor in these melanomas. The slight decrease of incidence of vulvar melanoma in dark pigmented individuals may be related to the biochemical protective effects of melanin (as an antioxidant) rather than their photo-screen effects.

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“…Squamous cell carcinoma accounts for approximately 85-90% of vulvar cancers [4,5], melanoma for 2.4-5% [4][5][6], and Bartholin gland carcinoma for 1-3% [4,7,8]. Very rare tumours are represented by basal cell carcinoma [9], invasive Paget's disease or intraepithelial Paget's disease with underlying adenocarcinoma [10], sarcoma [11] and metastatic tumours of the vulva [12], whereas endodermal sinus tumour [13,14] and primary breast carcinoma developing within breast ectopic tissue [15] are exceptional.…”

Section: Introductionmentioning

confidence: 99%