Population-Based, Multigenerational Family Clustering Study of Obsessive-compulsive Disorder

Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study

“…For example, the risk of OCD is more than double the risk of schizophrenia spectrum and bipolar disorders in first-degree relatives of probands with OCD, 45 suggesting disorderspecific genetic risk factors. Our longitudinal analyses further suggest that other mechanisms, over and above the possible shared genetic risks, may play a role in explaining the high comorbidity between these disorders, including the effects of medication, dynamic brain changes over time, or even possible misdiagnosis.…”

Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive–compulsive disorder

“…Twin and family studies have shown a high degree of heritability, around 50%, of this psychiatric disorder (Mataix-Cols et al, 2013;Tambs et al, 2009). More than 80 genetic association studies of OCD covering candidate genes that could be involved in the pathophysiology and pharmacology of OCD, have been published over the last decade.…”

Admixture analysis of age at symptom onset and age at disorder onset in a large sample of patients with obsessive–compulsive disorder

“…Biopsychosocial factors, including environmental and genetic factors play a key role in modulating the liability to OCD (Taylor et al, 2010). Indeed, OCD is familial and appears to be heritable: the risk for OCD in relatives is proportionally higher with increasing genetic relatedness to the proband (Mataix-Cols et al, 2013). Furthermore, up to 10% of OCD patients referred for treatment have at least another family member affected by the same disorder (Albert et al, 2002b).…”