Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan

Funahashi, Tomoko; Koyama, Toshihiro; Hagiya, Hideharu; Harada, Ko; Iinuma, Syunya; Ushio, Soichiro; Zamami, Yoshito; Niimura, Takahiro; Shinomiya, Kazuaki; Ishizawa, Keisuke; Sendo, Toshiaki; Hinotsu, Shiro; Kano, Mitsunobu R.

doi:10.1007/s40264-020-01037-9

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…The mean length of stay was 8.87 ± 4.61 days (1-27 days). The average number of medical diagnoses was 5.31 ± 2.79 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), and the average number of medications per patient was 17.93 ± 6.42 . 30.83% of the patients used antibacterial during hospitalization, and the main reason for use was pulmonary infection.…”

Section: Patients Characteristicsmentioning

confidence: 99%

“…From 1999 to 2020, China’s National Adverse Drug Reaction Monitoring Network received a total of 16.87 million copies of Adverse Drug Reaction (ADR)/ADE reports, compared with 1.676 million in 2020, of which 506,000 were new and severe ADEs ( 2 ). ADE-related deaths and trends have increased, especially in the elderly population ( 8 ), and are associated with longer hospital stays, a tripling risk of death, and increased costs ( 9 ). ADE has grown to be a serious public health issue that jeopardizes the security of pharmacological therapy globally and is one of the leading causes of iatrogenic injuries ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool

Yu,

Wu,

Yin

et al. 2023

Front. Med.

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BackgroundElderly patients frequently experience a high incidence of adverse drug events (ADEs) due to the coexistence of multiple diseases, the combination of various medications, poor medication compliance, and other factors. Global Trigger Tool (GTT) is a new method for identifying ADEs, introducing the concept of a trigger, that is, clues including abnormal laboratory values, reversal drugs, and clinical symptoms that may suggest ADEs, and specifically locating information related to ADEs in the medical record to identify ADEs. The aim of this study was to establish a GTT-based trigger tool for adverse medication events in elderly patients and to investigate the risk variables associated with such events.MethodsThe triggers were identified by reviewing the frequency of ADEs in elderly patients in Sichuan, China, retrieving relevant literature, and consulting experts. A retrospective analysis was carried out to identify adverse medication occurrences among 480 elderly inpatients in Sichuan People’s Hospital.ResultsA total of 56 ADEs were detected in 51 patients (10.62%), 13.04 per 1,000 patient days, and 11.67 per 100 admissions. The overall positive predictive value (PPV) of the triggers was 23.84, and 94.64% of ADEs caused temporary injury. Gastrointestinal system injury (27.87%) and metabolic and nutritional disorders (24.53%) were the primary organ-systems affected by ADEs. The majority of ADEs were caused by drugs used to treat cardiovascular diseases. 71.43% of ADE occurred within 2 days of administration and the risk factor analysis of ADE revealed that the number of medicines had a significant correlation.ConclusionThis study demonstrated GTT’s value as a tool for ADEs detection in elderly inpatients in China. It enhances the level of medication management and comprehensively reflects the situation of ADE of the elderly.

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Section: Patients Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool

Yu,

Wu,

Yin

et al. 2023

Front. Med.

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“…Adverse drug reactions (ADRs) are one of the primary reasons for hospitalization and account for approximately 1.7% to 11.0% of hospital admissions 1–6 . Furthermore, according to a 2016 study conducted in Japan, crude mortality related to ADRs was reported to be 1.01 per 100,000 people 7 . To prevent ADRs and maintain post‐marketing drug safety, pharmacovigilance was introduced for the detection, assessment, understanding and prevention of adverse effects or any other drug‐related problems 8 .…”

Section: What Is Known and Objective?mentioning

confidence: 99%

“…[1][2][3][4][5][6] Furthermore, according to a 2016 study conducted in Japan, crude mortality related to ADRs was reported to be 1.01 per 100,000 people. 7 To prevent ADRs and maintain post-marketing drug safety, pharmacovigilance was introduced for the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems. 8 In particular, spontaneous reporting of ADRs by healthcare professionals (HCPs) plays an important role in pharmacovigilance.…”

Section: What Is K Nown and Objec Tive?mentioning

confidence: 99%

Characteristics of hospitals that report adverse drug reactions: Results of a nationwide survey in Japan

Tsuchiya

Kikuchi

Hatakeyama

et al. 2022

Clinical Pharmacy Therapeu

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What is known and Objective Adverse drug reactions (ADRs) are one of the primary reasons for hospitalization. The spontaneous reporting of ADRs by healthcare professionals is important for issuing post‐marketing drug safety measures. The Japanese Society of Hospital Pharmacists (JSHP) conducts a nationwide survey annually. Using data from this large‐scale survey, we identified the characteristics of hospitals that reported ADRs to regulatory authorities and pharmaceutical companies. Methods Data were obtained from annual surveys conducted by JSHP from 2015 to 2020. All variables were expressed as categorical variables and tabulated. The Chi‐square test was used to compare the categorical variables. The Cochran–Armitage trend test was used to identify significant trends in the proportion of hospitals reporting ADRs. Results and Discussion From 2015 to 2020, 22,362 responses were recorded. There was a significant increase in the proportion of hospitals that reported ADRs with an increase in number of beds and pharmacists (p < 0.0001). The proportion of hospitals reporting ADRs to regulatory authorities was also significantly higher in those charging an additional fee for pharmacist‐performed ward operations and in those with an ADR data management section than in hospitals without these attributes (p < 0.0001). What is new and Conclusion Hospitals that submitted ADR reports to the regulatory authorities and pharmaceutical companies charged an additional fee for pharmacist‐performed ward operations, had a central ADR data management section, and had fewer beds per pharmacist. This trend was similar, regardless of the size of the hospital.

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Medikamentenkomplikationen – Dosisfindung und Interaktionen

Keller

Schulte-Kemna

2023

Geriatrische Nephrologie

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Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan

Cited by 6 publications

References 28 publications

Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool

Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool

Characteristics of hospitals that report adverse drug reactions: Results of a nationwide survey in Japan

Medikamentenkomplikationen – Dosisfindung und Interaktionen

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