Population-Based Pediatric Reference Intervals in General Clinical Chemistry: A Swedish Survey/Pedijatrijski Referentni Intervali U Opštoj Kliničkoj Hemiji Zasnovani Na Ispitivanju Populacije: Švedsko Ispitivanje

Ridefelt, Peter

doi:10.2478/jomb-2014-0050

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Mild iodine deficiency impairs intellectual development and can reduce the average population cognitive scores by 10–15% ( 18 ). Though neonatal TSH screening is a universal indicator of the severity of iodine deficiency, the proposed TSH cutoff level of 5 mIU/L has been regarded as not sensitive enough to detect mild iodine deficiency ( 17 , 19 – 23 ). Since frequency of TSH results > 5 mIU/L below 3% has been found in populations with mild iodine deficiency ( 17 ), the frequency below 3% which indicates iodine sufficiency should be reevaluated ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

Anastasovska¹,

Kočova²

2016

Journal of Medical Biochemistry

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SummaryBackgroundIodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population.MethodsA 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 48 hours after birth, using fluoroimmunometric DELFIA method.ResultsOut of 236,378 live-born infants, 228,266 (96.6%) have been screened for TSH, of which 198,213 (86.8%) were retrospectively evaluated for TSH levels above 5 mlU/L. Neonates with congenital hypothyroidism, prematurity, and low birth weight were excluded from the evaluation, as well as the inadequately sampled neonates (13.2%). A national prevalence of 3.08% newborns (n=6,105) with TSH > 5 mIU/L was found. Higher percentages were noted in two regions of the country, indicating possible mild iodine deficiency in these regions and shifting the overall average to above 3%.ConclusionsOur results indicate overall iodine sufficiency in the Macedonian population. Additional assessment of the iodine intake in the regions with suspected mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

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Section: Discussionmentioning

confidence: 99%

Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

Anastasovska¹,

Kočova²

2016

Journal of Medical Biochemistry

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“…Compared with the Abbott Architect c8000 analyzer of CALIPER [21], Abbott Architect ci8200 analyzer of Sweden [32], Roche Modular-P/ISE-system of Denmark [5], and Roche 9180 electrolyte analyzer of India [7], the Hitachi 7600-210 analyzer was used to establish electrolyte reference intervals in the present study. According to the CALIPER study, Ca detected by using the Abbott Architect c8000 analyzer was not transferable to Roche Modular-P [33].…”

Section: Discussionmentioning

confidence: 99%

Establishment and Verification of Sex- and Age-Specific Serum Electrolyte Reference Intervals in Healthy Han Children in Changchun, Northeastern China

Zhou

Jia

et al. 2019

BioMed Research International

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For lack of feasible interval values from population differences and potential analytical discrepancies, it is essential to ascertain potassium (K), sodium (Na), chlorine (Cl), calcium (Ca), and phosphorus (P) ions reference intervals within Chinese children to fill the gap. Healthy children (n = 1391, 2–<15 years old) were recruited from communities and schools to establish sex- and age-specific serum electrolyte reference intervals of Han children in Changchun, China. Levels of serum K, Na, Cl, Ca, and P were measured using a Hitachi 7600-210 automatic biochemical analyzer. Reference intervals were established according to Clinical and Laboratory Standards Institute EP28-A3c guidelines. Data from five representative hospitals located across Changchun were used to verify pediatric serum electrolyte reference intervals. Values were different from adult reference intervals in China. There were sex-specific differences in Na, Cl, Ca, and P reference intervals in 13-<14 children. Serum Na, Cl, and Ca reference intervals showed stable trends within early age groups but fluctuated in teens. Each serum electrolyte had ≤3 age-specific reference intervals. Five laboratories suggested reference intervals were applicable across Changchun.

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Pediatric Laboratory Medicine: Some Aspects of Obesity, Metabolic Syndrome, Neonatal Screening, Reference and Critical Values

Majkić-Singh¹

2014

Journal of Medical Biochemistry

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Population-Based Pediatric Reference Intervals in General Clinical Chemistry: A Swedish Survey/Pedijatrijski Referentni Intervali U Opštoj Kliničkoj Hemiji Zasnovani Na Ispitivanju Populacije: Švedsko Ispitivanje

Cited by 3 publications

References 4 publications

Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia

Establishment and Verification of Sex- and Age-Specific Serum Electrolyte Reference Intervals in Healthy Han Children in Changchun, Northeastern China

Pediatric Laboratory Medicine: Some Aspects of Obesity, Metabolic Syndrome, Neonatal Screening, Reference and Critical Values

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