Population‐based study of autoimmune conditions and the risk of specific lymphoid malignancies

Anderson, Lesley A.; Gadalla, Shahinaz M.; Morton, Lindsay M.; Landgren, Ola; Pfeiffer, Ruth M.; Warren, Joan L.; Berndt, Sonja I.; Ricker, Winnie; Parsons, Ruth; Engels, Eric A.

doi:10.1002/ijc.24287

Cited by 228 publications

(226 citation statements)

References 46 publications

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“…A previous epidemiological study reported that, out of 33,271 patients with NHL and 9,474 with multiple myeloma, 19 and 10 patients, respectively, had associated AA (5). The association between AA and HL, or as then termed, Hodgkin's disease, was anecdotally referenced in the 1920s, or even earlier (6).…”

Section: Discussionmentioning

confidence: 99%

“…Along with follicular mucinosis, AA has also been historically documented in panniculitis-like T-cell lymphoma, primary cutaneous follicle center lymphoma, cutaneous T-cell lymphomas, including mycosis fungoides and Sézary syndrome, as well as other non-Hodgkin's lymphomas (NHLs) (2)(3)(4)(5). AA, however, as a paraneoplastic syndrome of Hodgkin's lymphoma (HL), remains limited to a few case studies, although its occurrence in HL was anecdotally referenced in the early 1900s (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Alopecia areata as a paraneoplastic syndrome of Hodgkin’s lymphoma: A case report

Gong

Lim

2014

Molecular and Clinical Oncology

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Abstract. Alopecia areata (AA) has been classically associated with several autoimmune disorders. However, AA as a paraneoplastic syndrome of Hodgkin's lymphoma (HL) remains a rare entity and our understanding of this phenomenon is limited to a few case reports. This is the case report of a 46-year-old male patient who was diagnosed with AA several months prior to the onset of B symptoms and the diagnosis of stage IVB classical HL. The patient was subsequently treated with 6 cycles of adriamycin, bleomycin, vinblastine and dacarbazine and experienced a complete response and resolution of his AA. In our case, the onset of AA preceded the onset of systemic manifestations and diagnosis of HL, whereas in other cases AA was shown to occur concurrently with the clinical manifestations of HL. In all the cases, however, treatment of the HL subsequently led to resolution of the AA. The present case report highlights the significance of AA as a herald of underlying malignancy, although AA in classical HL remains poorly characterized in the literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alopecia areata as a paraneoplastic syndrome of Hodgkin’s lymphoma: A case report

Gong

Lim

2014

Molecular and Clinical Oncology

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“…2 Epstein-Barr virus (EBV) infections may be causally related to a number of cases as well as a personal history of autoimmune diseases. 3,4 However, there is limited evidence to the involvement of other specific environmental risk factors, although there is a distinctive pattern of incidence rates and risk profiles by age, race/ethnicity, sex and economic levels. 2 Some evidence for inherited genetic influence on susceptibility is provided by the increased familial risk and the very high concordance between monozygotic twins.…”

Section: Introductionmentioning

confidence: 99%

Heritability estimates on Hodgkin’s lymphoma: a genomic- versus population-based approach

et al. 2014

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Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) influencing the risk of Hodgkin's lymphoma (HL) and demonstrated the association of common genetic variation for this type of cancer. Such evidence for inherited genetic risk is also provided by the family history and the very high concordance between monozygotic twins. However, little is known about the genetic and environmental contributions. A common measure for describing the phenotypic variation due to genetics is the heritability. Using GWAS data on 906 HL cases by considering all typed SNPs simultaneously, we have calculated that the common variance explained by SNPs accounts for 435% of the total variation on the liability scale in HL (95% confidence interval 6-62%). These findings are consistent with similar heritability estimates of ∼ 0.40 (95% confidence interval 0.17-0.58) based on Swedish population data. Our estimates support the underlying polygenic basis for susceptibility to HL, and show that heritability based on the population data is somehow larger than heritability based on the genomic data because of the possibility of some missing heritability in the GWAS data. Besides that there is still major evidence for multiple loci causing HL on chromosomes other than chromosome 6 that need to be detected. Because of limited findings in prior GWASs, it seems worth checking for more loci causing susceptibility to HL.

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“…Celiac disease is associated with a 520-fold increased risk of enteropathy-associated T-cell lymphoma of the small intestine (EATL). Autoimmune conditions of the skin including psoriasis, pemphigus and discoid lupus erythematosus have an increased risk of T-cell cutaneous lymphoma (Anderson et al, 2009). Hodgkin lymphoma has also been associated with some autoimmune conditions, such as RA, SLE and sclerodermia.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Disorders and Lymphomas

Dolcetti¹,

Ponzoni²,

Mappa³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

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Population‐based study of autoimmune conditions and the risk of specific lymphoid malignancies

Cited by 228 publications

References 46 publications

Alopecia areata as a paraneoplastic syndrome of Hodgkin’s lymphoma: A case report

Alopecia areata as a paraneoplastic syndrome of Hodgkin’s lymphoma: A case report

Heritability estimates on Hodgkin’s lymphoma: a genomic- versus population-based approach

Autoimmune Disorders and Lymphomas

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