Population-Based Study of Bloodstream Infection Incidence and Mortality Rates, Finland, 2004–2018

Kontula, Keiju S. K.; Skogberg, Kirsi; Ollgren, Jukka; Järvinen, Asko; Lyytikäinen, Outi

doi:10.3201/eid2710.204826

Cited by 43 publications

(39 citation statements)

References 30 publications

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“… 19 In Finland, the incidence rose from 150 per 100,000 in 2004 to 309 per 100,000 in 2018. 4 In comparison, we found an incidence of 209 per 100,000 which included only eight pathogens and only adults, or approximately 300 per 100,000 adults if BSIs caused by all pathogens were captured. These results support the observation that BSI incidence is rising over time, driven, at least in part, by the rise in antibiotic resistance.…”

Section: Discussionmentioning

confidence: 69%

“…The reported CFR of BSI in previous population-based studies considered mainly short-term mortality (i.e., in-hospital or within 30 days) and ranged between 13-23% (including both CO- and HO-BSI). 2 , 4 , 20 , 21 , 22 , 23 , 24 Long-term mortality following BSI has been reported only from Calgary, Canada and from Denmark. The study from Canada reported a 1-year CFR of 28% in adult patients with BSI.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 Higher incidence rates were reported in recent years from Switzerland and Finland, reaching 240 and 309 cases/100,000, respectively. 3 , 4 The case fatality rate (CFR) of BSI varied greatly by the affected population (i.e., patients' age, sex and comorbidities), the virulence of the pathogen and its resistance to antibiotics, the appropriateness and timeliness of antibiotic therapy, and whether the infection was community- or hospital-onset. A few population-based studies determined BSI-associated mortality; based on these studies, Goto and Al-Hasan estimated the total number of BSIs and associated deaths and ranked BSI as one of the top seven causes of death in many high-income countries.…”

Section: Introductionmentioning

confidence: 99%

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One-year mortality and years of potential life lost following bloodstream infection among adults: A nation-wide population based study

Schechner

Wulffhart

Temkin

et al. 2022

The Lancet Regional Health - Europe

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

One-year mortality and years of potential life lost following bloodstream infection among adults: A nation-wide population based study

Schechner

Wulffhart

Temkin

et al. 2022

The Lancet Regional Health - Europe

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“…Bloodstream infection is one of the common causes of sepsis, and septic shock caused by uncontrolled inflammatory response is a major cause of death in patients with bloodstream infection in the ICU [ 14 , 15 ], with fatality rates increasing yearly [ 16 ]. Early and accurate identification and effective initial treatment can reduce the probability of severe sepsis progressing to septic shock and reduce mortality.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Procalcitonin and Neutrophil-to-Lymphocyte Ratio Variations for Bloodstream Infection with Septic Shock

Liang

2022

Med Sci Monit

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Background Little is known of neutrophil-to-lymphocyte ratio (NLR) variations in septic shock. Hence, the predictive value of procalcitonin (PCT) and NLR variations for septic shock in bloodstream infection were explored. Material/Methods We analyzed 146 patients with bloodstream infection admitted to the Intensive Care Unit (ICU) of the First Affiliated Hospital of Anhui Medical University from October 2016 to May 2020. PCT and NLR were evaluated at 0 and 48 h after admission, and their variations (ΔPCT and ΔNLR) were calculated. The patients were divided into a shock group (n=80) and a non-shock group (n=66) and a gram-positive cocci group (n=69) and a gram-negative bacilli group (n=77). The predictive value of ΔPCT and ΔNLR was compared among groups. Results AUROC of NLR0h (0.756) higher than PCT0h (0.743).ΔPCT (0.561 vs 0.301) and ΔNLR (0.609 vs 0.361) were significantly higher in the shock group than in the non-shock group ( P <0.05). No significant difference was seen in ΔPCT and ΔNLR in the gram-positive cocci infection group. However, the gram-negative bacilli infection group showed a significant difference in ΔPCT (0.606 vs 0.312) and ΔNLR (0.872 vs 0.508) between the shock and non-shock groups ( P <0.05). ΔPCT+ΔNLR showed the best area under the curve (0.937), with a high sensitivity (78.80%) and specificity (90.80%), for predicting septic shock. Conclusions The prediction efficiency of initial NLR is higher than that of PCT. ΔPCT+ΔNLR best predicted septic shock in patients with bloodstream infections, with better accuracy for gram-negative infections.

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“…Table 1 collects some of the data we have discussed [1,[4][5][6][1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Moreover, very few studies compare the evolution with respect to previous studies in the same region or hospital [13,19].…”

Section: Introductionmentioning

confidence: 99%

Unresolved issues in the epidemiology and diagnosis of bacteremia: an opinion paper

Alonso-Menchén¹,

Muñóz²,

Sánchez‐Carrillo³

et al. 2022

Rev Esp Quimioter

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Bacteremia is an important cause of morbidity and mortality worldwide and, despite the diagnostic and therapeutic advances of the last decades, the evidence supporting many diagnostic aspects of bacteremia is scarce. Information on the epidemiological evolution of this entity is limited and many methodological aspects of blood culture collection and analysis are under discussion. Furthermore, the recommendations of the main scientific societies on many of these aspects are variable and, in many cases, have not been updated recently. In this scenario, we have arranged a series of questions on different aspects of bacteremia and reviewed the literature trying to find proper answers for them. We offer our opinion on the topics where the evidence was weak. The topics covered include epidemiological aspects of bacteremia, indications for blood culture extraction, methods for obtaining and incubating samples, or ways of transmitting results from the microbiology laboratory. We do not intend to summarize the current clinical practice guidelines, nor will we deal with the therapeutic management of this entity. The aim of this paper is to review the current perspective on the diagnosis of bacteremia with a critical approach, to point out the gaps in the literature, to offer the opinion of a team dedicated to infectious diseases and clinical microbiology, and to identify some areas of knowledge on which future studies should focus.

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Population-Based Study of Bloodstream Infection Incidence and Mortality Rates, Finland, 2004–2018

Cited by 43 publications

References 30 publications

One-year mortality and years of potential life lost following bloodstream infection among adults: A nation-wide population based study

One-year mortality and years of potential life lost following bloodstream infection among adults: A nation-wide population based study

Predictive Value of Procalcitonin and Neutrophil-to-Lymphocyte Ratio Variations for Bloodstream Infection with Septic Shock

Unresolved issues in the epidemiology and diagnosis of bacteremia: an opinion paper

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