Population-based study of early-onset neonatal sepsis in Canada

Sgro, Michael; Kobylianskii, Anna; Yudin, Mark H.; Tran, Dat; Diamandakos, Julia; Sgro, Jonathan; Campbell, Douglas M.

doi:10.1093/pch/pxy018

Cited by 16 publications

(6 citation statements)

References 44 publications

(94 reference statements)

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“…Importantly, these estimates remain high when compared to those in high income countries. For instance, the incidence of early onset cSBI is ten times higher when compared to those in North America (0.17 to 1 per 1,000 live births) [ 12 – 14 ]. In LMICs, recent studies are scare, but available ones from Asia and Sub-Saharan Africa showed slightly lower incidence of cSBI when compared to results of BIRDY 2 (estimated incidence in Bangladesh (one month follow-up): 3.0, in India (two months follow-up): 6.7 and in Kenya (two months of follow-up): 5.5 cSBI per 1,000 live births) [ 15 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Devred,

Rambliere,

Herindrainy

et al. 2023

BMC Infect Dis

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Background Few studies on neonatal severe bacterial infection are available in LMICs. Data are needed in these countries to prioritize interventions and decrease neonatal infections which are a primary cause of neonatal mortality. The BIRDY project (Bacterial Infections and Antimicrobial Drug Resistant among Young Children) was initially conducted in Madagascar, Senegal and Cambodia (BIRDY 1, 2012–2018), and continued in Madagascar only (BIRDY 2, 2018–2021). We present here the BIRDY 2 project whose objectives were (1) to estimate the incidence of neonatal severe bacterial infections and compare these findings with those obtained in BIRDY 1, (2) to identify determinants associated with severe bacterial infection and (3) to specify the antibiotic resistance pattern of bacteria in newborns. Methods The BIRDY 2 study was a prospective community-based mother and child cohort, both in urban and semi-rural areas. All pregnant women in the study areas were identified and enrolled. Their newborns were actively and passively followed-up from birth to 3 months. Data on clinical symptoms developed by the children and laboratory results of all clinical samples investigated were collected. A Cox proportional hazards model was performed to identify risk factors associated with possible severe bacterial infection. Findings A total of 53 possible severe bacterial infection and 6 confirmed severe bacterial infection episodes were identified among the 511 neonates followed-up, with more than half occurring in the first 3 days. For the first month period, the incidence of confirmed severe bacterial infection was 11.7 per 1,000 live births indicating a 1.3 -fold decrease compared to BIRDY 1 in Madagascar (p = 0.50) and the incidence of possible severe bacterial infection was 76.3, indicating a 2.6-fold decrease compared to BIRDY 1 in Madagascar (p < 0.001). The 6 severe bacterial infection confirmed by blood culture included 5 Enterobacterales and one Enterococcus faecium. The 5 Enterobacterales were extended-spectrum β-lactamases (ESBL) producers and were resistant to quinolones and gentamicin. Enterococcus faecium was sensitive to vancomycin but resistant to amoxicillin and to gentamicin. These pathogns were classified as multidrug-resistant bacteria and were resistant to antibiotics recommended in WHO guidelines for neonatal sepsis. However, they remained susceptible to carbapenem. Fetid amniotic fluid, need for resuscitation at birth and low birth weight were associated with early onset possible severe bacterial infection. Conclusion Our results suggest that the incidence of severe bacterial infection is still high in the community of Madagascar, even if it seems lower when compared to BIRDY 1 estimates, and that existing neonatal sepsis treatment guidelines may no longer be appropriate in Madagascar. These results motivate to further strengthen actions for the prevention, early diagnosis and case management during the first 3 days of life.

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Section: Discussionmentioning

confidence: 99%

Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Devred,

Rambliere,

Herindrainy

et al. 2023

BMC Infect Dis

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“…Instead, late-onset neonatal sepsis (LONS) develops three days after birth, with Staphylococcus spp. being the most often observed pathogens [13] . This cross-sectional study was carried out at NICU of Kasr Al-Ainy Hospital, Cairo University, Egypt, from Janurary 2018 to August 2018.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil: Lymphocyte Ratio, Mean Platelet Volume and Serum Uric Acid as a Diagnostic and Prognostic Marker of Neonatal Sepsis

AMIRA A. ELGAMMAL, M.D.*; MOHAMED

2023

The Medical Journal of Cairo University

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Background: Neonatal sepsis is still a significant cause of morbidity and mortality.Aim of Study: Was to determine the typical pathogens that cause neonatal sepsis in neonates admitted to the neonatal intensive care unit, to determine the impact of neonatal sepsis on blood results, and to determine the significance of mean platelet volume, uric acid levels and neutrophil lymphocyte ratio in the early diagnosis of neonatal sepsis. Patients and Methods:The study involved seventy cases and 70 matched healthy neonates that were recruited. All newborns had been examined with emphasis on the perinatal history, maternal history and focus on newborn risk factors. Sepsis screen was done in addition to mean platelets volume and uric acid serum levels.Results: MPV was used as a predictor for sepsis diagnosis: at the cutoff value of 9.15 fL had a sensitivity of 88% and specificity of 70% with a positive predictive value (PPV) of 50%, negative predictive value (NPV) of 94.9% and accuracy of 75%. Used as a predictor of sepsis diagnosis, serum uric acid had a PPV of 60.5%, NPV of 88.2%, and accuracy of 20%. It also had a sensitivity of 65.7% and specificity of 85.7%.Conclusions: Mean platelets volume, uric acid and neutrophil: Lymphocyte ratio serve as early indicators of neonatal sepsis as compared to the blood culture in diagnosis of neonatal sepsis diagnosis.

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“…En Canadá se logró demostrar que la rotura prematura de membranas prolongado ocurre en las 26 semanas de gestación debido a infecciones vaginales por las bacterias de Escherichia coli y Estreptococo del grupo B donde se asocia a una sepsis neonatal, los síntomas más frecuentes que se muestra es un peso al nacer es menor de 2000 g, dificultad respiratoria, vómito, letargia e inestabilidad térmica, además las características para un diagnóstico son un hemocultivo, hemograma, VSG y la proteína C reactiva (Sgro et al, 2019).…”

Section: Introductionunclassified

Sepsis neonatal: factores de riesgo, sintomatología clínica y marcadores diagnósticos.

Calderón¹,

Zambrano²,

Pincay³

2023

MQRInvestigar

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La sepsis neonatal es una infección de la sangre que se presenta a partir de los 90 días de nacido. El objetivo de esta investigación fue describir los factores de riesgo, sintomatologías clínicas y marcadores diagnósticos de la sepsis neonatal. El diseño metodológico fue documental con un tipo de estudio exploratorio, por medio de una revisión bibliográfica entre los años 2016 a 2023, se usó como estrategia de búsqueda las bases de datos de: National Center For Biotechnology Information, SCIELO, PLOS ONE, Dialnet, Frontiers, Parto F Springer Nature, MEDISAN, Springer link, Taylor y Francis Online. Los resultados de los estudios se enfatizaron que los factores de riesgo para una sepsis neonatal son las infecciones del tracto urinario de las mujeres embarazadas predominando las infecciones por bacterias como Estreptococos del grupo B y, otro factor es la ventilación mecánica. Los síntomas clínicos son dificultades respiratorias y fiebre mayor de 37 grados. Los Marcadores diagnósticos oportunos de sepsis neonatal son la Proteína C reactiva y a la biometría hemática, otros marcadores son los niveles procalcitonina y citocinas. Además, la prueba para la detección específica es un hemocultivo para el reconocimiento de la infección bacteriana. Concluyendo que la sepsis del recién nacido es una problemática de la salud donde existen varios factores para la aparición de la enfermedad, por otro lado, la descripción de esta patología como la sintomatología clínica y los marcadores de laboratorio es un aporte para un diagnóstico rápido y oportuno para un tratamiento seguro.

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Population-based study of early-onset neonatal sepsis in Canada

Cited by 16 publications

References 44 publications

Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Incidence and risk factors of neonatal bacterial infections: a community-based cohort from Madagascar (2018–2021)

Neutrophil: Lymphocyte Ratio, Mean Platelet Volume and Serum Uric Acid as a Diagnostic and Prognostic Marker of Neonatal Sepsis

Sepsis neonatal: factores de riesgo, sintomatología clínica y marcadores diagnósticos.

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