“…P days supplied study period (this method is sometimes called the medication refill adherence) [57, 84, 89, 120, 131-133, 148, 165, 166, 174, 180, 183] (4) P days supplied study period À inpatient days [80] (5) P days supplied À inpatient days study period À inpatient days [80] mMPR: in this case, the denominator of the MPR is modified from days between first and last prescription to days between first and last dispensing+duration of last prescription (6) P days supplied days between first and last dispensing þ duration of last prescription in days [29,46,82,[94][95][96][97] (7) ( P days supplied of each inhaler device )=number of inhalers duration of therapy [179] Unclear MPR calculation [87,113,142,143,164,175] PDC: the proportion of days covered is the ratio of the sum of the days covered by a medication (numerator) to a fixed time period (denominator, e.g. 365 days) [4,11] or to the study period [4,13] Denominator: fixed time period ( 8) study period [116][117][118] Other definitions of PDC (14) The relationship between the proportion of the billed doses of pharmacy and the number of days covered according to the labelling of the product [33,90] (15) Quantity dispensed (unclear whether in days or canisters) fixed time period [153] No definition available [58,164,169] Unclear definition [34] A combination of PDC and MPR: the numerator is a variant of the days supplied or the days covered and/or the denominator is a fixed time period or a variant of the study period…”