Population-based study of lymphoma in Germany: rationale, study design and first results

Becker, Nicholas

doi:10.1016/s0145-2126(03)00405-3

Cited by 13 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors hypothesised that “the persisting effect of exposure in childhood suggests that contact with animals in childhood could have a role in the pathogenetic process, possibly due to viruses acting as oncogenic initiators or as immunosuppressors”. A German23 and a US24 case–control study of NHL did not observe an association for living in a rural environment in childhood. However ‘living in a rural environment’ may not entail the same exposure as ‘growing up on a farm’, and no distinction between crop or livestock farming was made.…”

Section: Discussionmentioning

confidence: 84%

“…However, we did observe an increased risk for haematological cancer associated with beef cattle farming, while in contrast we observed a decreased risk among dairy cattle farmers. Risk estimates for cattle farming have been reported in other studies, showing increased risks for leukaemia,36 37 NHL38 and HL,23 but a distinction between beef cattle farming and dairy cattle farming was not made. One study from Canada differentiated between dairy farming and beef cattle farming39 and found a statistically significant increased risk for both leukaemia and NHL associated with beef cattle, but not for dairy cattle, similar to our findings.…”

Section: Discussionmentioning

confidence: 89%

“…Although not entirely consistent,23 these studies generally show an increased NHL risk for more crowded situations in childhood and for having more siblings,24–27 giving some indication that early life circumstances with higher potential for infection are associated with an elevated risk. The increased risk from growing up on a livestock farm, and the lack of an association for growing up on a crop farm that we observed in this study, suggest that the observed risk could be due to specific animal related exposures rather than the farming environment in general.…”

Section: Discussionmentioning

confidence: 96%

See 2 more Smart Citations

Farming, growing up on a farm, and haematological cancer mortality

Mannetje

Eng²,

Pearce³

2011

Occup Environ Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Farming, growing up on a farm, and haematological cancer mortality

Mannetje

Eng²,

Pearce³

2011

Occup Environ Med

View full text Add to dashboard Cite

show abstract

“…The study design has been described in detail in previous publications [16,17]. Briefly, the study was conducted under the leadership of the German Cancer Research Center (DKFZ) in six defined regions in Germany: Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Würzburg/Lower Frankonia, Hamburg, Bielefeld/Guetersloh, and Munich.…”

Section: Methodsmentioning

confidence: 99%

Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

Seidler

Möhner

Berger

et al. 2007

J Occup Med Toxicol

View full text Add to dashboard Cite

AimsTo analyze the relationship between exposure to chlorinated and aromatic organic solvents and malignant lymphoma in a multi-centre, population-based case-control study.MethodsMale and female patients with malignant lymphoma (n = 710) between 18 and 80 years of age were prospectively recruited in six study regions in Germany (Ludwigshafen/Upper Palatinate, Heidelberg/Rhine-Neckar-County, Würzburg/Lower Frankonia, Hamburg, Bielefeld/Gütersloh, and Munich). For each newly recruited lymphoma case, a gender, region and age-matched (± 1 year of birth) population control was drawn from the population registers. In a structured personal interview, we elicited a complete occupational history, including every occupational period that lasted at least one year. On the basis of job task-specific supplementary questionnaires, a trained occupational physician assessed the exposure to chlorinated hydrocarbons (trichloroethylene, tetrachloroethylene, dichloromethane, carbon tetrachloride) and aromatic hydrocarbons (benzene, toluene, xylene, styrene). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking (in pack years) and alcohol consumption. To increase the statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression analysis.ResultsWe observed a statistically significant association between high exposure to chlorinated hydrocarbons and malignant lymphoma (Odds ratio = 2.1; 95% confidence interval 1.1–4.3). In the analysis of lymphoma subentities, a pronounced risk elevation was found for follicular lymphoma and marginal zone lymphoma. When specific substances were considered, the association between trichloroethylene and malignant lymphoma was of borderline statistical significance. Aromatic hydrocarbons were not significantly associated with the lymphoma diagnosis.ConclusionIn accordance with the literature, this data point to a potential etiologic role of chlorinated hydrocarbons (particularly trichloroethylene) and malignant lymphoma. Chlorinated hydrocarbons might affect specific lymphoma subentities differentially. Our study does not support a strong association between aromatic hydrocarbons (benzene, toluene, xylene, or styrene) and the diagnosis of a malignant lymphoma.

show abstract

“…33 34 Briefly, the study was conducted under the leadership of the German Cancer Research Center (DKFZ) in six defined regions in Germany: Ludwigshafen/Upper five from other lymphoma. According to the WHO classification, B-non-Hodgkin's lymphoma were further subdivided into the following subentities (only subentities with n.30 cases are mentioned): diffuse large B-cell lymphoma (n = 158); follicular lymphoma (n = 92); chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma (SLL) (n = 104); plasma cell myeloma (plasmacytoma) (n = 76); and marginal zone B-cell lymphoma (n = 38).…”

Section: Study Populationmentioning

confidence: 99%

Occupation and malignant lymphoma: a population based case control study in Germany

Mester

Nieters²,

Deeg³

et al. 2005

Occup Environ Med

View full text Add to dashboard Cite

Aims: To identify occupations suspected to be associated with malignant lymphoma and to generate new hypotheses about occupational risks in a multicentre, population based case control study. Methods: Male and female patients with malignant lymphoma (n = 710) aged 18-80 years of age were prospectively recruited in six study regions in Germany. For each newly recruited lymphoma case, a sex, region, and age matched control was drawn from the population registers. Odds ratios and 95% confidence intervals for major occupations and industries were calculated using conditional logistic regression analysis, adjusted for smoking (in pack-years) and alcohol consumption. Patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression analysis. Results: The following economic/industrial sectors were positively associated with lymphoma: food products, beverages, tobacco; paper products, publishing and printing; and metals. Chemicals; real estate, renting, and business activities were negatively associated with lymphoma diagnosis. The authors observed an increased overall lymphoma risk among architects; maids; farmers; glass formers; and construction workers. Shoemaking and leather goods making was negatively associated with the lymphoma diagnosis (although based on small numbers). In the occupational group analysis of lymphoma subentities, Hodgkin's lymphoma was significantly associated only with rubber and plastic products making; diffuse large B cell lymphoma risk was considerably increased among metal processors; follicular lymphoma showed highly significant risk increases for several occupational groups (medical, dental, and veterinary workers; sales workers; machinery fitters; and electrical fitters); and multiple myeloma showed a particularly pronounced risk increase for farmers as well as for agriculture and animal husbandry workers. Conclusions:The results partly confirm previously defined occupational risks. Occupational risk factors for follicular lymphomas might differ from the overall risk factors for malignant lymphoma. During the past few decades, the incidence of nonHodgkin's lymphoma (NHL) increased in most Western countries. [1][2][3][4] Only recent data indicate a leveling off of this trend. In Germany, NHL made up an estimated 3% of the male and 3.4% of the female incident cancer cases in 2000. 5The aetiology of malignant lymphoma is still largely unknown. Strong evidence exists for the association between NHL and congenital or acquired immunosuppression, especially AIDS.6-10 Immune factors also seem to play a role in the aetiology of Hodgkin's lymphoma:7 an excess has been found after transplantations 11 12 as well as among HIV infected patients. 14The known risk factors explain only a small proportion of malignant lymphoma. Several studies point to a potential aetiological role of occupational factors to malignant lymphoma. Hodgkin The aim of the present multicentre, population based case control study is to identify occupati...

show abstract

Population-based study of lymphoma in Germany: rationale, study design and first results

Cited by 13 publications

References 0 publications

Farming, growing up on a farm, and haematological cancer mortality

Farming, growing up on a farm, and haematological cancer mortality

Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

Occupation and malignant lymphoma: a population based case control study in Germany

Contact Info

Product

Resources

About