Population characteristics of golden retriever lifetime study enrollees

Simpson, Melissa J; Searfoss, Erin E.; Albright, Sharon; Brown, Diane E.; Wolfe, Barbara A.; Clark, Nancy K; McCann, Susan E.; Haworth, David; Guy, Mike; Page, Rod

doi:10.1186/s40575-017-0053-5

Cited by 19 publications

(20 citation statements)

References 20 publications

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“…Such observations mean that genetic and environmental risk factors for cancer may be identified in smaller prospective studies, taking less time, than would be necessary in people. The leading cause of death in Golden retrievers is hematopoietic malignancy (86), and in 2012 a prospective study of >3,000 Goldens, enrolled at age 2 or younger, was undertaken (87). The goal of this study was to collect environmental and biological data for correlation with the future diagnoses of malignancy and other diseases.…”

Section: Exploiting Breed-specific Diseases For Prevention and Diseasmentioning

confidence: 99%

The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma

Avery

2020

Front. Oncol.

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Emerging details of the gene expression and mutational features of canine lymphoma and leukemia demonstrate areas of similarities and differences between disease subsets in the humans and dogs. Many features of canine diffuse large B-cell lymphoma resemble the ABC form of human DLBCL, including constitutive activation of the NF-kB pathway, and almost universal presence of double expressing MYC/BCL2 lymphomas. Frequent TRAF3 mutations and absence of BCL6 expression are differences with the human disease that need further exploration. Canine peripheral T-cell lymphoma is more common in dogs than in people and behaves in a similarly aggressive manner. Common features of canine and human PTCL include activation of the PI3 kinase pathways, loss of PTEN, and the tumor suppressor CDKN2. There is insufficient data available yet to determine if canine PTCL exhibits the GATA3-TBX21 dichotomy seen in people. Common to all forms of canine lymphoproliferative disease are breed-specific predilections for subsets of disease. This is particularly striking in PTCL, with the Boxer breed being dramatically overrepresented. Breed-specific diseases provide an opportunity for uncovering genetic and environmental risk factors that can aid early diagnosis and prevention.

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Section: Exploiting Breed-specific Diseases For Prevention and Diseasmentioning

confidence: 99%

The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma

Avery

2020

Front. Oncol.

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“…In four years, the GRLS has amassed a sample set of over 3,000 Golden Retrievers, complete with annual biological samples and standardized phenotype data collection from owners and veterinarians (Simpson et al, 2017), and represents a one-of-a-kind dataset for genomic analysis. Here, we combine detailed reproductive data gathered on 93 GRLS participants with high-density SNP genotyping.…”

Section: Introductionmentioning

confidence: 99%

Inbreeding depression causes reduced fecundity in Golden Retrievers

Chu¹,

Simpson

Diehl

et al. 2019

Preprint

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Inbreeding depression has been demonstrated to impact vital rates, productivity, and performance in many domestic species. Many in the field have demonstrated the value of genomic measures of inbreeding compared to pedigree-based estimates of inbreeding; further, standardized, high-quality phenotype data on all individuals is invaluable for longitudinal analyses of a study cohort. We compared measures of reproductive fitness in a small cohort of Golden Retrievers enrolled in the Golden Retriever Lifetime Study (GRLS) to a genomic measurement of inbreeding, FROH. We demonstrate a statistically significant negative correlation between fecundity and FROH.This work sets the stage for larger scale analyses to investigate genomic regions associated with fecundity and other measures of fitness.

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“…Nearly 35% of farm dogs in the current study were covered by an insurance policy. This is higher than the 20% insurance coverage reported in Golden retrievers enrolled in a longitudinal study in the United States [36]. Additionally, in Australia it has been estimated that about 7% of dog owners have pet insurance [37], however it has been suggested that this might be an underestimate [38].…”

Section: Discussionmentioning

confidence: 86%

TeamMate: A longitudinal study of New Zealand working farm dogs. I. Methods, population characteristics and health on enrolment.

Isaksen

Linney

Williamson

et al. 2019

Preprint

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Background Working farm dogs are invaluable on New Zealand sheep and beef farms. To date no study describing farm dog population and health has included information about incidence of illness and injury, or risk factors affecting health and career duration. This paper describes the methodology and initial results from TeamMate, a longitudinal study that was designed to address this gap. We describe the study population, husbandry practices, and prevalence of clinical abnormalities on enrolment. Methods Data about the farms, owners, husbandry practices and dogs were collected on farm at approximately 6-month intervals. All dogs over 18 months old and in full work were enrolled. Dogs were given physical examinations by veterinarians. On examination all abnormalities were noted, regardless of clinical significance. Results Six hundred forty-one working farm dogs and 126 owners were enrolled from the South Island of New Zealand. Forty-nine percent of dogs were Heading dogs (314 of 641) and 48% Huntaways (308 of 641). Median age of dogs was four years (range 1.5 – 14) and median body condition score (BCS) was four on a 9-point scale (interquartile range (IQR) 3 – 5). Fifty-four percent of dogs were male (345 of 641), and 6% (41 of 641) were neutered. Eighty-one percent of owners (102 of 126) fed dogs commercial biscuits and meat sourced on farm. Forty-four percent of dogs (279 of 641) had bedding in their kennel, 14% (55 of 393) had insulated kennels, 69% (442 of 641) had been vaccinated and 33% (213 of 641) were insured. Clinical abnormalities were found in 74% of dogs (475 of 641). Common abnormalities involved the musculoskeletal system (43%, 273 of 641), skin (including scars and callouses; 42%, 272 of 641), and oral cavity (including worn and broken teeth; 35%, 227 of 641). Conclusions Our results expand on those from previous surveys and indicate that musculoskeletal illness and injury, and skin trauma are the most commonly seen clinical abnormalities in working farm dogs. These results will provide a baseline for investigation of incidence and risk factors for illness, injury, retirement and death in New Zealand working farm dogs.

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Population characteristics of golden retriever lifetime study enrollees

Cited by 19 publications

References 20 publications

The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma

The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma

Inbreeding depression causes reduced fecundity in Golden Retrievers

TeamMate: A longitudinal study of New Zealand working farm dogs. I. Methods, population characteristics and health on enrolment.

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