Population coding in spike trains of simultaneously recorded retinal ganglion cells

Fernández, Eduardo; Ferrández, José Manuel; Ammermüller, Josef; Normann, Richard A.

doi:10.1016/s0006-8993(00)03072-9

Cited by 47 publications

(27 citation statements)

References 33 publications

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“…Extracellular recordings were obtained from ganglion cell populations in isolated superfused albino rabbit (Oryctolagus cuniculus) retina using a rectangular array of 100, 1.5 mm long electrodes, as reported previously (Fernandez et al, 2000;Normann et al, 2001a;Ortega et al, 2004;Bonomini et al, 2005). Briefly, after enucleation of the eye, the eyeball was hemisected with a razor blade, and the cornea and lens were separated from the posterior half.…”

Section: Methodsmentioning

confidence: 99%

“…The electrode array was connected to a 100 channel amplifier (low and high corner frequencies of 250 and 7500 Hz) and a digital signal processor based data acquisition system. Neural spike events were detected by comparing the instantaneous electrode signal to level thresholds set for each data channel using standard procedures described elsewhere (Fernandez et al, 2000;Normann et al, 2001a;Shoham et al, 2003). When a supra-threshold event occurs, the signal window surrounding the event is time-stamped and stored for later, offline analysis.…”

Section: Methodsmentioning

confidence: 99%

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Artificial Neural Networks and Retinal Ganglion Cell Responses

Bonomini¹,

Ferrández²,

Fernández³

2011

Artificial Neural Networks - Methodological Advances and Biomedical Applications

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Artificial Neural Networks and Retinal Ganglion Cell Responses

Bonomini¹,

Ferrández²,

Fernández³

2011

Artificial Neural Networks - Methodological Advances and Biomedical Applications

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“…Extracellular recordings were obtained from ganglion cells in the isolated superfused albino rabbit (Oryctolagus cuniculus) retina using a rectangular array of 100, 1.5 mm long electrodes with platinized tips, as reported previously (Fernández et al, 2000). After enucleation of the eye, the eyeball was hemisected with a razor blade, and the cornea and lens were separated from the posterior half.…”

Section: Methodsmentioning

confidence: 99%

“…Separation and classification of these action potentials on each functional electrode was done off-line. Single unit classification was accomplished with an unsupervised statistical classification method using mixture modeling (Fernández et al, 2000;Normann et al, 2001;Shoham et al, 2003;Warren et al, 2001). Each spike consisted of 48 time samples (1.6 ms).…”

Section: Methodsmentioning

confidence: 99%

“…An emerging view in neuroscience is that sensory and motor information is processed in a parallel fashion by populations of neurons working in concert (Fernández et al, 2000;Nicolelis, 1999;Nicolelis and Ribeiro, 2002;Panzeri et al, 1999). Encouraged by this progress many laboratories are investing considerable effort into the development of recording techniques and spike-sorting algorithms that permit simultaneous recording of the activity of multiple neurons (Kralik et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Conditioned spikes: a simple and fast method to represent rates and temporal patterns in multielectrode recordings

Ortega

Bongard

Louis

et al. 2004

Journal of Neuroscience Methods

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Increasing evidence suggests that the brain utilizes distributed codes that can only be analyzed by simultaneously recording the activity of multiple neurons. This paper introduces a new methodology for studying neural ensemble recordings. The method uses a novel representation to provide complementary information about the stimuli which are contained in the temporal pattern of the spike sequence. By using this procedure, a high correlation of synchronized events with stimuli times is apparent. To quantify the results and to compare the performance of this method against the most traditional raster plot, we have used Fano factor and cross-correlation analysis. Our results suggest that several consecutive spikes from different neurons within an extended time window may encode behaviorally relevant information. We propose that this new representation, in addition to the other approaches currently used (standard raster plots, multivariate statistical methods, neuronal networks, information theory, etc.), can be a useful procedure to describe population spike dynamics.

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Visual Prostheses

Delbeke

Veraart

2006

Encyclopedia of Medical Devices and Instrumentation

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A visual prosthesis is an active implantable device intended to restore vision in a blind person. Present day systems are only partially implanted. A number of different approaches are under development. These are mainly classified on the basis of their interface to the visual nervous system. One particular approach resorts to chemical activation of the retina. All others use electrical stimulation applied subretinally, epiretinally, transretinally, to the optic nerve, on the visual cortex, or in the visual cortex. These systems can typically be described as a chain comprising a camera or image grabbing unit, a processor, a telemetry unit, an implanted stimulator and an implanted electrode. Localized phosphenes have been obtained and exploited to convey a primitive form of visual information to the brain. Feasibility has been demonstrated, but a clinical evaluation has yet to come. Many aspects of these devices are still open to rapid and significant development.

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Population coding in spike trains of simultaneously recorded retinal ganglion cells

Cited by 47 publications

References 33 publications

Artificial Neural Networks and Retinal Ganglion Cell Responses

Artificial Neural Networks and Retinal Ganglion Cell Responses

Conditioned spikes: a simple and fast method to represent rates and temporal patterns in multielectrode recordings

Visual Prostheses

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