Population data on the expanded CODIS core STR loci for eleven populations of significance for forensic DNA analyses in the United States

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We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.

Section: Methodsmentioning

confidence: 99%

Internal validation of STRmix™ – A multi laboratory response to PCAST

Bright

Richards

Kruijver

et al. 2018

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“…The FBI extended allele frequencies [13] were used in the LR calculations separately for Caucasian, African American, and South Eastern Hispanic populations, without subpopulation correction (i.e. assuming Hardy-Weinberg equilibrium and linkage equilibrium).…”

Section: Population Stratificationmentioning

confidence: 99%

The efficacy of DNA mixture to mixture matching

Bright

Taylor

Kerr

et al. 2019

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  We investigate a method to identify a common contributor in two mixed DNA profiles  The discrimination power is limited by the smallest DNA contribution to the profiles  We show good ability to find pairs of profiles with a common contributor  This tool gives the ability to provide intelligence information

“…This scenario examines the performance of the Federal Bureau of Investigation (FBI) [24] and National Institute of Standards and Technology (NIST) [23] databases with regard to profiles simulated in other databases. For each ethnic cluster, the cognate database is each of the databases in that cluster except for the FBI and NIST databases of that ethnic group.…”

Section: B) Federal Bureau Of Investigation (Fbi) and National Institmentioning

confidence: 99%

The factor of 10 in forensic DNA match probabilities

Gittelson

Moretti

Onorato

et al. 2017

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An update was performed of the classic experiments that led to the view that profile probability assignments are usually within a factor of 10 of each other. The data used in this study consist of 15 Identifiler loci collected from a wide range of forensic populations. Following Budowle et al. [1], the terms cognate and non-cognate are used. The cognate database is the database from which the profiles are simulated. The profile probability assignment was usually larger in the cognate database. In 44%-65% of the cases, the profile probability for 15 loci in the non-cognate database was within a factor of 10 of the profile probability in the cognate database. This proportion was between 60% and 80% when the FBI and NIST data were used as the non-cognate databases. A second experiment compared the match probability assignment using a generalised database and recommendation 4.2 from NRC II (the 4.2 assignment) with a proxy for the matching proportion developed using subpopulation allele frequencies and the product rule. The findings support that the 4.2 assignment has a large conservative bias. These results are in agreement with previous research results.