Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis

Schmidt, Wolf‐Peter; Suzuki, Motoi; Thiem, Vu Dinh; White, Richard G.; Tsuzuki, Ataru; Yoshida, Lay‐Myint; Yanai, Hideki; Haque, Ubydul; Tho, Le Huu; Anh, Đặng Đức; Ariyoshi, Koya

doi:10.1371/journal.pmed.1001082

Cited by 213 publications

(207 citation statements)

References 28 publications

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“…A recent publication showed that secondary DENV-2 infections could result from more virulent clades than others, depending on the serotype of the primary infecting serotype, DENV-1 or DENV-3. 21 Under these conditions, the development dynamics of epidemics, the function of the implicated genotypes, and the intervals between the successive epidemics, 22 the immune and genetic status of the population, 23 and other environmental factors such as the population density, 24 the climate and density of mosquitoes of the Aedes genus, 25 could create specific situations in each endemic region and thus create many confounding factors. This could explain the differences in results shown in various publications on the theme of clinical presentation by serotype.…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentation of Dengue by Serotype and Year of Epidemic in Martinique

Thomas

Najioullah

Besnier

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. During the last decade Martinique experienced four dengue epidemics, each characterized by the predominance of 1 or 2 serotypes. In this retrospective database analysis, we investigated the relationship between dengue serotype and disease severity. Data on dengue were collected from 715 patients (male/female ratio 0.87), 14 to 91 years of age (median 35 years) examined in the adult emergency department between 2005 and 2010. In this series, DENV-4 infections more frequently had a milder clinical presentation. The DENV-2 infections were most often secondary infections admitted at the critical phase of dengue illness with signs of plasma leakage. The DENV-1 infections were disabling, particularly in females, and most often led to disease of intermediate severity, without overt plasma leakage. These data were consistent with there being differences in virulence between serotypes, regardless of the host's immune status. However, secondary DENV-2 infections showed an increased risk of plasma leakage.

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Section: Discussionmentioning

confidence: 99%

Clinical Presentation of Dengue by Serotype and Year of Epidemic in Martinique

Thomas

Najioullah

Besnier

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…The urban areas are comprised of 391 census units in Hermosillo and 69 in Navojoa. Neighborhood characteristics included: median age as an indicator of susceptibility, unemployment status (%) as an indicator of socio-economic standing, population with no health care (%) as a modifier of being detected and reported as a dengue case, migrant population in the last 5 years (%) as an indicator of mobility of the population and potential viral introduction, and houses with no piped water (%) as a proxy for water storage which may provide larval habitat and overall infrastructure that may influence vector-human contact (Padmanabha et al, 2010;Schmidt et al, 2011). Three additional variables; persons per house, occupied houses (%) and population density (persons per hectare) were used as indicators of proximity between individuals which can influence Ae.…”

Section: Data Sources and Variablesmentioning

confidence: 99%

“…Three additional variables; persons per house, occupied houses (%) and population density (persons per hectare) were used as indicators of proximity between individuals which can influence Ae. aegypti dynamics and the transmission patterns among residents (Rodrigues et al, 2015;Schmidt et al, 2011). Census data were available for 2010 which coincided with the outbreak in Hermosillo but was two years after the 2008 outbreak in Navojoa.…”

Section: Data Sources and Variablesmentioning

confidence: 99%

Spatio-temporal and neighborhood characteristics of two dengue outbreaks in two arid cities of Mexico

et al. 2017

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Little is currently known about the spatial-temporal dynamics of dengue epidemics in arid areas. This study assesses dengue outbreaks that occurred in two arid cities of Mexico, Hermosillo and Navojoa, located in northern state of Sonora. Laboratory confirmed dengue cases from Hermosillo (N=2,730) and Navojoa (N=493) were geocoded by residence and assigned neighborhood-level characteristics from the 2010 Mexican census. Kernel density and Space-time cluster analysis was performed to detect high density areas and space-time clusters of dengue. Ordinary Least Square regression was used to assess the changing socioeconomic characteristics of cases over the course of the outbreaks. Both cities exhibited contiguous patterns of space-time clustering. Initial areas of dissemination were characterized in both cities by high population density, high percentage of occupied houses, and lack of healthcare. Future research and control efforts in these regions should consider these space-time and socioeconomic patterns.

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“…Cependant si ces facteurs influencent potentiellement le cycle de contamination, ils ne sont pas systéma-tiquement identifiés comme tels, car le résultat des causalités non linéaires entre ces facteurs dépend des contextes locaux. La connaissance de ces relations permet malgré tout la mise en oeuvre d'actions à différentes échelles pour tenter d'améliorer les conditions de santé publique : contrôle régulier des gîtes en eau (Abe et al, 2005), mesures de protection intra domiciliaires (Singh et al, 2011), amélioration des conditions d'accès à l'eau des populations (Schmidt et al, 2011), interventions selon les types d'usages du sol (Thammapalo et al, 2008) ou encore politiques de planification urbaine (De Mattos Almeida et al, 2007).…”

Section: L'environnementunclassified

La dengue, maladie complexe

2015

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La diffusion et l'émergence des risques sanitaires constituent une préoccupation très présente dans les discours actuels sur la mondialisation et les changements climatiques. La dengue y occupe une place de choix depuis qu'elle a été diagnostiquée sporadiquement aux portes de l'Europe et que son vecteur fréquente une part croissante de nos territoires nationaux. Cette question souvent traitée en termes de causalité trouve dans cet article une remise en perspective extrêmement utile, montrant que le risque ne naît pas d'une succession d'événements mais bien d'une articulation complexe de facteurs. En cela, les auteurs nous proposent d'interpréter la variabilité de l'expression de la maladie comme le produit aussi bien d'interactions à l'interface natures/sociétés que d'un dialogue entre disciplines, remettant en cause tout déterminisme dans la dynamique de ce risque sanitaire. La RédactionRésumé -La dengue est une infection virale à transmission vectorielle qui touche, pour l'instant, essentiellement les pays de la zone tropicale et subtropicale. Nous développons un cadre systémique et complexe pour l'étude de cette maladie, qui permet à la fois de décomposer ses différentes entités -hôte, vecteur, virus, environnement -tout en affirmant le poids de leurs interactions dans ses dynamiques potentielles. L'étude de cette complexité systémique s'enrichit d'un cadre méthodologique qui permet d'intégrer dans un même modèle des dynamiques biologiques et sociales, dans des environnements changeants. Ce cadre de recherche implique de nouvelles pratiques, il rend indispensable une collaboration étroite des sciences sociales, environnementales, biologiques et informatiques, sans oublier l'implication des populations et des acteurs locaux de santé publique.Abstract -Dengue, a complex disease. Dengue is a widespread mosquito-borne viral infection in tropical and subtropical countries causing an estimated 500 million infections per year of which more than 20,000 result in severe disease. Since the 1970s dengue has spread and become endemic in more than 100 countries and there is concern that dengue will spread into temperate regions. The peridomestic niche of the primary mosquito vector, Aedes aegypti, results in dengue being a largely urban and periurban disease where the high population densities cause major epidemics. Although a number of risk factors have been identified at different spatial scales of analysis, their general relevance is debatable. Very local scale environmental factors can determine both the abundance of mosquitoes and their ability to transmit the virus. Thus the environmental complexity of urban settings coupled with heterogeneity in human population density yield potentially complex interactions in highly differentiated local conditions that are difficult to assess. We are developing a complex framework to enable a more tractable understanding of dengue epidemiology. This framework enables the disentanglement of actors, host, vector, virus and environment, all the while asserting the dynamic contributi...

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Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis

Abstract: Results from 75,000 geo-referenced households in Vietnam during two dengue epidemics reveal that human population densities typical of villages are most prone to dengue outbreaks; rural areas may contribute as much to dissemination of dengue fever as do cities.

Cited by 213 publications

References 28 publications

Clinical Presentation of Dengue by Serotype and Year of Epidemic in Martinique

Clinical Presentation of Dengue by Serotype and Year of Epidemic in Martinique

Spatio-temporal and neighborhood characteristics of two dengue outbreaks in two arid cities of Mexico

La dengue, maladie complexe

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